Diterpenoids from Isodon lophanthoides

Jiang, Bei; Lu, Ze-Qin; Zhang, Hongjie; Zhao, Qin‐Shi; Sun, Han‐Dong

doi:10.1016/s0367-326x(00)00126-x

Cited by 33 publications

(22 citation statements)

References 7 publications

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“…Most rural areas of Guizhou are economically underdeveloped, and their medical care heavily relies on folk medicines passed on from generation to generation. As part of the ethnomedicinal program (Jiang et al, 2000;Li et al, 2015;Zou et al, 2011Zou et al, , 2012Xiang et al, 2004), we have researched Miao traditional medicine in the Leigong Mountain region, the highest mountain in southeastern Guizhou with an average elevation of about 1800 meters. The mountainous region covers a total area of 47,300 hectares, and is one of the designated national forest parks in China.…”

Section: Introductionmentioning

confidence: 99%

Discovery of antifungal constituents from the Miao medicinal plant Isodon flavidus

Guan

et al. 2016

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Discovery of antifungal constituents from the Miao medicinal plant Isodon flavidus

Guan

et al. 2016

Journal of Ethnopharmacology

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“…The title compound is atypical abietane diterpenoid and shows antimicrobial, antiulcer, and cardiovasculara ctivities [1][2].I n 1995 the crystal structure was analysed, but no crystal data were given in the paper [3].Inorder to further confirm the structure and providecompletecrystal data,werepeated the work.The compound crystallizes with two molecules in the trigonalcrystal system with space group P3 1 2 1 (figure). Geometric parameters of the titlecompoundare in the usual ranges.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 13-hydroxy-8(9)-abieten-20-oic acid, C20H32O3

Liu¹,

Li²,

Li³

et al. 2012

Zeitschrift für Kristallographie - New Crystal Structures

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“…Adenanthin (ADNT), a diterpenoid compound that is extracted from the herb Isodon adenantha, 22 has been shown to inhibit the antioxidant activity of PRDX1 and, to a lesser extent, PRDX2. 23 Our team 24 and others 25 have further described that such actions are mediated by the regulation of intramolecular or intermolecular disulphide bonds.…”

Section: M M U N O L O G Y O R I G I N a L A R T I C L Ementioning

confidence: 99%

Adenanthin, a new inhibitor of thiol‐dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

et al. 2015

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SummaryNatural killer (NK) cells are considered critical components of the innate and adaptive immune responses. Deficiencies in NK cell activity are common, such as those that occur in cancer patients, and they can be responsible for dysfunctional immune surveillance. Persistent oxidative stress is intrinsic to many malignant tumours, and numerous studies have focused on the effects of reactive oxygen species on the anti-tumour activity of NK cells. Indeed, investigations in animal models have suggested that one of the most important thiol-dependent antioxidant enzymes, peroxiredoxin 1 (PRDX1), is essential for NK cell function. In this work, our analysis of the transcriptomic expression pattern of antioxidant enzymes in human NK cells has identified PRDX1 as the most prominently induced transcript out of the 18 transcripts evaluated in activated NK cells. The change in PRDX1 expression was followed by increased expression of two other enzymes from the PRDX-related antioxidant chain: thioredoxin and thioredoxin reductase. To study the role of thiol-dependent antioxidants in more detail, we applied a novel compound, adenanthin, to induce an abrupt dysfunction of the PRDX-related antioxidant chain in NK cells. In human primary NK cells, we observed profound alterations in spontaneous and antibody-dependent NK cell cytotoxicity against cancer cells, impaired degranulation, and a decreased expression of activation markers under these conditions. Collectively, our study pinpoints the unique role for the antioxidant activity of the PRDX-related enzymatic chain in human NK cell functions. Further understanding this phenomenon will prospectively lead to fine-tuning of the novel NK-targeted therapeutic approaches to human disease.

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Diterpenoids from Isodon lophanthoides

Cited by 33 publications

References 7 publications

Discovery of antifungal constituents from the Miao medicinal plant Isodon flavidus

Discovery of antifungal constituents from the Miao medicinal plant Isodon flavidus

Crystal structure of 13-hydroxy-8(9)-abieten-20-oic acid, C20H32O3

Adenanthin, a new inhibitor of thiol‐dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

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