Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Islam, Muhammad Torequl; Mubarak, Mohammad S.

doi:10.1002/ptr.6562

Cited by 13 publications

(10 citation statements)

References 68 publications

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“…Some of these diterpenoid and biflavonoid compounds from the leaf extract of T. nucifera exhibited antiviral property against a broad spectrum of viruses. Among the diterpenoids, ferruginol and its derivatives were reported to show anti-DENV effect against Dengue virus serotype 2 (Islam & Mubarak, 2020;Roa-Linares et al, 2016). Another ferruginol derivative 18-oxoferruginol had shown antiviral activity against the Dengue virus as well as human herpesvirus type 2 (Roa-Linares et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves

Ghosh

Chakraborty

Biswas

et al. 2020

Journal of Biomolecular Structure and Dynamics

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SARS CoV-2 is the causative agent of the pandemic disease COVID-19. There is an urgent need for effective drugs or vaccines which can effectively combat this outbreak. The main protease (Mpro), a key component for the SARS CoV-2 replication, is considered to be one of the important drug targets for developing anti-COVID-19 drugs. This SARS CoV-2 Mpro/cysteine protease has high sequence similarity with the same protease from SARS CoV-1. Previously, it has been shown experimentally that eight diterpenoids and four biflavonoids derived from the leaf of Torreya nucifera show inhibitory effect on the cleavage/catalytic activity of the SARS CoV-1 Mpro. But whether these phytochemicals exhibit any inhibitory effect on SARS CoV-2 Mpro is unclear. To understand this fact, here, we have adopted various in-silico approaches. Diterpenoids and biflavonoids those qualified pharmacological test (hinokiol, amentoflavone, bilobetin and ginkgetin) and two well-known Mpro inhibitors (N3 and lopinavir) were subjected for molecular docking studies. Only three biflavonoids (amentoflavone, bilobetin and ginkgetin) were selected by comparing their binding affinities with N3 and lopinavir. They interacted with two most important catalytic residues of Mpro (His41 and Cys145). Molecular dynamics studies further revealed that these three Mpro-biflavonoid complexes are highly stable and share a similar degree of compactness. Besides, these complexes experience less conformational fluctuations and more expansion than Mpro-N3 and/or Mpro-lopinavir complex. MM-GBSA and H-bond analysis further corroborated these findings. Altogether, our study suggested that these three biflavonoids could possibly inhibit the proteolytic/catalytic activity of SARS CoV-2 Mpro and might be useful for COVID-19 treatment.

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Section: Introductionmentioning

confidence: 99%

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves

Ghosh

Chakraborty

Biswas

et al. 2020

Journal of Biomolecular Structure and Dynamics

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“…Another phenolic compound, Quercetin (a flavanol), potentially downregulates TNF-α in an attempt to control the excessive inflammation [ 129 ]. Phorbol ester (PMA) is also an inhibitor of the TNF-α levels post-DENV infection [ 130 , 131 ]. Although there are many such phenolic compounds, such as, Fisetin, Naringin, Catechin, and Delphinidin, that showed inhibitory effects on the DENV in pre- and post-treatments, their mechanisms of inhibition have yet to be clarified [ 132 , 133 , 134 , 135 ].…”

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware

Banerjee

Bagchi

et al. 2021

Viruses

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Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses.

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“…albopictus larvae and could be useful for the development of environmentally benign IGR insecticides to control mosquitoes [143]. Moreover, the beneficial effects of diterpene and their derivatives as well as their potential use as biological alternatives in dengue fever control has been highlighted [218].…”

Section: New Insecticide Igr and Repellent Compoundsmentioning

confidence: 99%

Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

2020

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Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most important mosquito-borne diseases, such as arboviruses and malaria. This resurgence may be the consequence of numerous complex parameters, but the major cause remains the mismanagement of insecticide use and the emergence of resistance. Biological control programmes have rendered promising results but several highly effective techniques, such as genetic manipulation, remain insufficiently considered as a control mechanism. Currently, new strategies based on attractive toxic sugar baits and new agents, such as Wolbachia and Asaia, are being intensively studied for potential use as alternatives to chemicals. Research into new insecticides, Insect Growth Regulators, and repellent compounds is pressing, and the improvement of biological strategies may provide key solutions to prevent outbreaks, decrease the danger to at-risk populations, and mitigate resistance.Pathogens 2020, 9, 310 2 of 26 are not used at all, and those that are still in the test or design phase but are very promising, which we suggest to be considered in the biological control of mosquito-borne diseases.

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Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Cited by 13 publications

References 68 publications

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

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