Disulfiram Induced Psychosis

Mohapatra, Satyakam; Rath, Nihar Ranjan

doi:10.9758/cpn.2017.15.1.68

Cited by 20 publications

(17 citation statements)

References 10 publications

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“…By inhibiting dopamine β-hydroxylase, DSF simultaneously reduces NE and elevates DA in these tissues. A link has been established between psychosis and DSF-induced increase of DA in the mesolimbic system (10,33). Dopamine β-hydroxylase is also expressed in some peripheral sensory neurons and it has been suggested that neurotoxic products of catecholamines metabolism in nociceptors can cause neuronal dysfunction underlying neuropathic pain (34).…”

Section: Dsf Neuronal Toxicity ?mentioning

confidence: 99%

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Trautmann

Gascan

Ghozzi³

2020

Front. Med.

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Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a key enzyme for detoxifying the organism after alcohol ingestion. Other targets and modes of action of disulfiram, that may present problematic side effects, are less commonly mentioned. The French Federation against Tick Borne Diseases (French acronym, FFMVT), which associates three main Lyme patient organizations, MDs and PhDs, has recently been alerted to severe and persistent toxic events in a patient suffering from a late disseminated form of Lyme Disease following disulfiram intake. FFMVT reacted by launching a national call to examine whether other patients in France following a similar treatment could be identified, and what benefits, or side effects could be reported. The statements of 16 patients taking disulfiram have been collected and are presented here. Thirteen out of 16 patients reported toxic events, and seven out of 16 reported benefits for at least part of their symptoms. Based on the collected observations, it seems too early to promote disulfiram as a promising new treatment until the reasons underlying the reported toxicities have been explored, and the results of a well-conducted double blind clinical trial published. The importance of taking into account patient-reported outcomes in Lyme Disease is underlined by the present study.

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Section: Dsf Neuronal Toxicity ?mentioning

confidence: 99%

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Trautmann

Gascan

Ghozzi³

2020

Front. Med.

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“…Disulfiram is commonly used in dosages of 250-500 mg/day. 1 Although well tolerated by most patients, severe toxic side effects have also been reported including hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy. 2 We are reporting a case of disulfiram toxicity in a 4.5-year girl who ingested 4-5 tablets of disulfiram (approximately 1-1.25 g) accidentally and presented with hypoglycemia and encephalopathy.…”

Section: Introductionmentioning

confidence: 99%

Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature

Bhalla

Mittal

Gupta

et al. 2011

Indian Journal of Critical Care Medicine

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Aim:To determine the significance of acute disulfiram poisoning in pediatric population. Background: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Although well tolerated by most patients, severe toxic side effects have been also reported including hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy. Case description: This is a case report of disulfiram toxicity in a 4.5-year girl who ingested 4-5 tablets of disulfiram (approximately 1-1.25 g) accidentally and presented with hypoglycemia and encephalopathy. After initial stabilization in emergency room, the child was shifted to intensive care unit (ICU) where the child was managed conservatively. Blood sugars normalized after 8 hours of admission. Magnetic resonance imaging (MRI) brain showed bilateral globus pallidus hyperintensity in T2-weighted (T2W) and diffusion-weighted (DW) images and hypointensity in T1-weighted (T1W) images including diffusion restriction. Conclusion: Acute disulfiram poisoning can occur in children who have ingested large amount of drug because of unsafe storage. It can lead to hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy. Mainstay of treatment is supportive care, airway protection, oxygen, and dextrose-containing intravenous fluid should be given. Clinical significance: Acute disulfiram poisoning should be an important differential in diagnosis of any child presenting with idiopathic encephalopathy along with extrapyramidal symptoms with basal ganglia signal changes in MRI of brain in a previously healthy child.

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“…We read with great interest the recently published article by Mohapatra and Rath 1) regarding a case of psychosis after treatment with disulfiram. Because of our continuous research on disulfiram and its side effects, we find the issue very interesting and we would like to comment briefly on this report.…”

mentioning

confidence: 99%

“… 2) Implying that this is a dose-dependent phenomenon they recommended that disulfiram should be used at the lowest effective dose, possibly 250 mg daily. 1) …”

mentioning

confidence: 99%