Comment on: Disulfiram Induced Psychosis (Mohapatra and Rath, Clin Psychopharmacol Neurosci 2017;15:68-69)

Karamanakos, Petros N; Panteli, Eleftheria S

doi:10.9758/cpn.2017.15.3.296

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…[6] Several case reports of disulfiram-induced psychosis exist. [141516] Vulnerable factors identified through these case reports include the past or family history of psychosis. This warrants need for assessment of potential role of genetic factors in our population.…”

Section: Resultsmentioning

confidence: 99%

Pharmacotherapy for relapse prevention of alcohol use disorder in the Indian setting: A systematic review

2018

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Alcohol use disorders (AUDs) is an important public health concern as estimates of the prevalence of AUD range at 4%–6% in the Indian population. Currently, there is limited literature on the pharmacotherapeutic interventions for AUD in the Indian setting. It is imperative to identify the possible variations in their effects from Western studies, and hence the current review was attempted to perform a comprehensive evaluation and critical appraisal of the methodology of the evidence on pharmacological strategies of relapse prevention of AUD in the Indian setting. A total of 18 studies were included in the review. Disulfiram was the most common pharmacological agent to be studied. The initial literature before 2000 focused primarily on disulfiram, whereas the studies in the next decade compared it to acamprosate and naltrexone and emerging interest in anticraving agents such as baclofen and topiramate had been noted over the past few years. No studies were available on newer agents such as ondansetron, selective serotonin reuptake inhibitors or formulations such as depot and implants. Deterrent agents were found to be better when compared to anticraving agents in terms of abstinence and relapse, whereas the latter were more effective for control of craving. Among the pharmacological agents studied, the greatest evidence exists for disulfiram for relapse prevention which could be due to affordability of disulfiram and social support in the Indian context. The chief methodological limitations include the lack of randomized trials and objective measures for assessing abstinence.

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Section: Resultsmentioning

confidence: 99%

Pharmacotherapy for relapse prevention of alcohol use disorder in the Indian setting: A systematic review

2018

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Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection

Miller

2024

Explor Neuroprot Ther

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Transmethylation in the context of psychiatry has historically referred to the enzymatic transfer of a methyl group from one biochemical to another, whose resulting function can change so dramatically that a biochemical like tryptamine, for example, is converted into the hallucinogen dimethyltryptamine. Central to endogenous methylation activity is the folate cycle, which generates the primary transferable methyl groups in mammalian biochemistry. The relevance of this cycle to mental health becomes clear when the cycle is dysregulated, often leading to a buildup of both homocysteine and S-adenosylhomocysteine (SAH), while accompanied by a transient reduction in the intended physiologic target, S-adenosylmethionine (SAM). This paper includes an in-depth review of the causes of folate cycle perturbations associated with psychotic symptoms, expounding on alternative downstream pathways which are activated and pointing toward potential etiologic agents of the associated psychosis, the methylated tertiary amines N-methyl-salsolinol, N-methyl-norsalsolinol, and adrenochrome, which appear in scientific reports concerning their association with hallucinogenic and/or neurotoxic outcomes. Electrotopological state (E-state) data has been generated for these compounds, illustrating a strong similarity with hallucinogens, particularly in terms of the E-state of the nitrogen in their tertiary amine moieties. In light of the role the folate cycle plays in transmethylation, neuroprotective strategies to prevent the transition to psychosis are suggested, including the advisory that folate supplementation can be harmful depending on the status of other relevant biochemicals.

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Comment on: Disulfiram Induced Psychosis (Mohapatra and Rath, Clin Psychopharmacol Neurosci 2017;15:68-69)

Cited by 2 publications

References 4 publications

Pharmacotherapy for relapse prevention of alcohol use disorder in the Indian setting: A systematic review

Pharmacotherapy for relapse prevention of alcohol use disorder in the Indian setting: A systematic review

Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection

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