Disulfide-crosslinked albumin hydrogels

Sun, Yuling; Huang, Yanjiang

doi:10.1039/c6tb00247a

Cited by 67 publications

(53 citation statements)

References 34 publications

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“…Disulfides, formed by the reaction of two thiol groups, play a ubiquitous role in protein folding and assembly . Disulfide crosslinked hydrogels require the presence of an oxidation agent to form; however, oxygen itself is sufficient to drive crosslinking . This way, disulfide bonds can be broken down or reform via physiologically relevant reduction/oxidation and/or thiol‐disulfide exchange reactions.…”

Section: Dynamic Covalent Chemistry To Form Hydrogelsmentioning

confidence: 99%

“…Utilizing the 35 thiol groups naturally existing in albumin, disulfide‐crosslinked albumin hydrogels were formed without the need to introduce new chemical moieties. The albumin hydrogel was highly swollen and mechanically weak in deionized water; however, it collapsed in neutral buffer with two orders of magnitude increase in storage modulus . A drug‐loaded BSA hydrogel was shown to be injectable through a 26 Gauge needle.…”

Section: Dynamic Covalent Chemistry To Form Hydrogelsmentioning

confidence: 99%

“…The albumin hydrogel was highly swollen and mechanically weak in deionized water; however, it collapsed in neutral buffer with two orders of magnitude increase in storage modulus. 213 A drug-loaded BSA hydrogel was shown to be injectable through a 26 Gauge needle. The model drug doxorubicin was released from albumin hydrogels over 29 days with incomplete release likely due to the presence of strong doxorubicin-albumin interactions.…”

Section: Disulfide Bondsmentioning

confidence: 99%

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Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

Uman

Dhand

Burdick

2019

J of Applied Polymer Sci

243

215

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Shear‐thinning and self‐healing hydrogels are being investigated in various biomedical applications including drug delivery, tissue engineering, and 3D bioprinting. Such hydrogels are formed through dynamic and reversible interactions between polymers or polypeptides that allow these shear‐thinning and self‐healing properties, including physical associations (e.g., hydrogen bonds, guest–host interactions, biorecognition motifs, hydrophobicity, electrostatics, and metal–ligand coordination) and dynamic covalent chemistry (e.g., Schiff base, oxime chemistry, disulfide bonds, and reversible Diels–Alder). Their shear‐thinning properties allow for injectability, as the hydrogel exhibits viscous flow under shear, and their self‐healing nature allows for stabilization when shear is removed. Hydrogels can be formulated as uniform polymer and polypeptide assemblies, as hydrogel nanocomposites, or in granular hydrogel form. This review focuses on recent advances in shear‐thinning and self‐healing hydrogels that are promising for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48668.

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Section: Dynamic Covalent Chemistry To Form Hydrogelsmentioning

confidence: 99%

Section: Dynamic Covalent Chemistry To Form Hydrogelsmentioning

confidence: 99%

Section: Disulfide Bondsmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

Uman

Dhand

Burdick

2019

J of Applied Polymer Sci

243

215

View full text Add to dashboard Cite

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“…Thus, Huang et al. studied disulfide cross‐linked albumin hydrogels by taking advantage of the inherent thiol groups of albumin . They prepared hydrogels with intermolecular disulfide bonds and characterized their features.…”

Section: Applicationsmentioning

confidence: 99%

Sulfur Chemistry in Polymer and Materials Science

Mutlu

Ceper

et al. 2018

Macromol. Rapid Commun.

255

220

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/marc.201800650. ChemistryBefore moving to the recent advances within the last 5 years in the diverse applications of sulfur chemistry in polymer and Sulfur-Containing PolymersSulfur and its functional groups are major players in an area of exciting research taking place in modern polymer and materials science, both in academia and industry. In fact, manifold sulfur-based reactions that are both exceptionally versatile as well as tremendously useful have been implemented, and further utilized for the design and preparation of polymeric materials that lead to a plethora of applications ranging from medicine to optics and nanotechnology to separation science. Hence, within this review, an overview of strategies and developments used over the last 5 years to reinforce the importance of the sulfur functional group in modern polymer and materials science is presented. In particular, many important references in the primary literature of sulfur chemistry are referred to, including thiol-ene, thiol-yne, thiol-Michael addition, disulfide cross-linking, and thiol-disulfide exchange, among others, by explaining and illustrating the important principles. Last but not least, the grand aim to underpin the importance of sulfur in modern polymer and materials science is achieved by presenting selected examples in diverse fields and postulating the respective potential for real-world applications. he is now a full professor at KIT.sulfur atoms, and tetraphenylethene-bearing di(alkyl bromide) (Scheme 3). The yield of the polymerization was dependent on the di(alkyl bromide) monomer; the longer spacer between the aromatic moiety and the reactive bromide end groups Scheme 1. The discussion henceforth focuses on the synthesis of polymers possessing the depicted sulfur functional groups. Scheme 2.Representative examples of polythioethers prepared via A) the nucleophilic substitution reaction between an electrophilic dihalide with nucleophilic derivatives of dithiols under alkaline conditions; B) the thiol-ene/yne addition reaction between AA and BB type monomers (i.e., dithiols and dienes/diynes); and C) radical or ionic ring-opening of sulfurcontaining strained rings.Scheme 3. The thiol-bromo polymerization of conformationally fixed monomers to provide multifunctional polymers. [19] Macromol. Rapid Commun. 2019, 40, 1800650 Scheme 4. The regioselective selective nucleophilic aromatic substitution between thiol and fluorinated aromatic compounds, the para-fluorothiol reaction (PFTR).Scheme 5. Synthesis of a linear polymer via PFTR-reaction. [21]

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“…Considering that BSA has 21 tyrosines, it is an ideal template for the design and synthesis of natural globulin protein hydrogels via dityrosine bonds. However, dityrosine bond cross-linked BSA gels may exhibit brittle properties, similar to other gels (Sun and Huang, 2016;Fernandez-Castano Romera et al, 2017;Lü et al, 2017;Kabb et al, 2018;Picchioni and Muljana, 2018).…”

Section: Introductionmentioning

confidence: 96%

High-Strength Albumin Hydrogels With Hybrid Cross-Linking

Zhu

Wang

et al. 2020

Front. Chem.

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Natural protein-based hydrogels possess excellent biocompatibility; however, most of them are weak or brittle. In the present work, high strength hybrid dual-crosslinking BSA gels (BSA DC gels), which have both chemical cross-linking and physical cross-linking, were fabricated by a facile photoreaction-heating process. BSA DC gels showed high transparency (light transmittance of ∼90%) and high strength. At optimal conditions, BSA DC gel exhibited high compressive strength (σ c,f) of 37.81 ± 2.61 MPa and tensile strength (σ t,f) of 0.62 ± 0.078 MPa, showing it to be much stronger than physically cross-linked BSA gel (BSA PC gel) and chemically cross-linked BSA gel (BSA CC gel). More importantly, BSA DC gel displayed non-swelling properties while maintaining high strength in DI water, pH = 3.0, and pH = 10.0. Moreover, BSA DC gel also demonstrated large hysteresis, rapid self-recovery, and excellent fatigue resistance properties. It is believed that our BSA DC gel can potentially be applied in biomedical fields.

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Disulfide-crosslinked albumin hydrogels

Abstract: Albumin hydrogels crosslinked by disulfide bonds between the protein's own thiol groups.

Cited by 67 publications

References 34 publications

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

Sulfur Chemistry in Polymer and Materials Science

High-Strength Albumin Hydrogels With Hybrid Cross-Linking

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