Disturbances in production of progesterone and their implications in plant studies

Janeczko, Anna; Oklešťková, Jana; Novák, Ondřej; Śniegowska-Świerk, Katarzyna; Snaczke, Zuzanna; Pociecha, Ewa

doi:10.1016/j.steroids.2015.01.025

Cited by 24 publications

(21 citation statements)

References 54 publications

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“…Like in Arabidopsis, BR plays similar effect on reproduction in other plants species. In monocotyledonous wheat, exogenous application of 24-epibrassinolide delays vegetative to generative transition, while the BR inhibitor, Brassinazole, accelerates the transition and heading stage [111]. In short-day plant Pharbitis nil, treatment of BL and CS inhibit flowering in combination with the inductive photoperiod, suggesting that BR integrates with environmental cues for the proper reproductive transition [112].…”

Section: Role Br In Other Plant Speciesmentioning

confidence: 99%

Roles of Brassinosteroids in Plant Reproduction

2020

IJMS

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Brassinosteroids (BRs) are a group of steroid hormones, essentially important for plant development and growth. BR signaling functions to promote cell expansion and cell division, and plays a role in etiolation and reproduction. As the phytohormone originally identified in the pollen grains of Brassica napus, BR promotes the elongation of stigma. Recent studies have revealed that BR is also critical for floral transition, inflorescence stem architecture formation and other aspects of plant reproductive processes. In this review, we focus on the current understanding of BRs in plant reproduction, the spatial and temporal control of BR signaling, and the downstream molecular mechanisms in both the model plant Arabidopsis and crops. The crosstalk of BR with environmental factors and other hormones in reproduction will also be discussed.Int. J. Mol. Sci. 2020, 21, 872 2 of 16 BRI1 KINASE INHIBITOR 1 (BKI1) [14][15][16][17]. Then the kinase domains of BRI1 and BAK1 are transphosphorylated and the phosphorylated BKI1 can associate with the 14-3-3 family proteins to further amplify BR signaling [16,18]. Another two plasma membrane-anchored cytoplasmic kinases, BRASSINOSTEROID-SIGNALLING KINASE 1 (BSK1) and CONSTITUTIVE DIFFERENTIAL GROWTH 1 (CDG1) are also phosphorylated by activated BRI1 to inactivate the phosphatase BRI1-SUPPESSOR 1 (BSU1) [19][20][21]. BSU1 in turn dephosphorylates a conserved tyrosine residue of BRASSINOSTEROID INSENSITIVE 2 (BIN2), leading to the inactivation of this GSK3-like kinase [22]. The function of BIN2 is to phosphorylate and inactivate two homologous transcription factors, BRASSINAZOLE RESISTANT 1 (BZR1) and BR1-EMS-SUPPRESSSOR 1 (BES1) in the absence of BR [23][24][25]. The phosphorylation leads to the deactivation of these two transcription factors [26]. In high BR level, BSU1 inactivates BIN2 and unphosphorylated BZR1 and BES1 can initiate BR regulated gene activation and repression [23,27]. BZR1 and BES1 initiate BR responsive gene expression by recognizing and binding to the BR response DNA cis-element BR-Response Element (BRRE, CGTGC/TG) and E-box (CANNTG) [23,28]. Gain-of-function bzr1-1D and bes1-D contain a proline to leucine mutation in the protein degradation domain and therefore exhibit BR constitutive phenotypes [24,25,29]. However, the bzr1-1D and bes1-D are morphologically different, indicating the two proteins are involved in distinct BR functions. A number of transcription factors and histone modifiers are identified to interact with BZR1/BES1 for the control of various BR responses [28,[30][31][32][33]. BZR1 and BES1 belong to a six-member small family clade, consisting another four homologs, BES1/BZR1 homolog 1 to 4 (BEH1-4), which also act as downstream transcription factors in BR signaling pathway [28].BR regulates a broad range of plant growth and development, including hypocotyl elongation, root development, skotomorphogenesis, vascular differentiation, floral transition, anther development, and pollen grain maturation. In this review, we will focus on the functions ...

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Section: Role Br In Other Plant Speciesmentioning

confidence: 99%

Roles of Brassinosteroids in Plant Reproduction

2020

IJMS

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“…II) Maiores concentrações de PGA no substrato induzem a planta à alterar seu metabolismo radicular de forma a impedir a absorção ou metabolizar a PGA em subprodutos não detectados pelo método utilizado (JANECZKO et al, 2015).…”

Section: Resultsunclassified

Detecção De Progesterona Em Tecidos Vegetais De Lactuca Sp. Por Espectroscopia De Uv

Fabbris¹,

Nicolini²

2017

MUNDI SB

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Resumo: A sociedade pós-moderna usa diversas substâncias para melhorar a sua qualidade de vida. Inúmeras dessas substâncias são fármacos e muitos desses já são considerados contaminantes emergentes e presentes em diversos locais devido à ação antrópica. Há uma preocupação da comunidade científica mundial no sentido de monitorar os contaminantes emergentes e estabelecer protocolos de quantificação que possam estabelecer limites de tolerância dessas substâncias e assim proteger as comunidades humanas de possíveis problemas de saúde advindos dessa contaminação. Há indícios de inúmeros contaminantes emergentes (antimicrobianos, fungicidas, hormônios, anti-inflamatórios) em águas de superfície e em alimentos. O objetivo do presente trabalho foi avaliar a presença de progesterona em tecidos vegetais da alface (Lactuca sp.) através da espectroscopia ultravioleta (UV). As plantas foram cultivadas in vitro e testadas frente a diferentes concentrações de progesterona (5,10,100 e 1000 ppm). A parte da planta coletada para análise foi as folhas, utilizou-se como solvente etanol 92,8 o GL. Foi detectada a presença de progesterona após o intervalo de um dia da contaminação do substrato até o oitavo dia, sendo que as concentrações encontradas foram entre 0,14 e 1,11 ppm no extrato etanólico das folhas. Esse estudo indica a potencial contaminação de plantas, quando estas são irrigadas com água proveniente de mananciais contaminados com progesterona e seus metabólitos o que significa o consumo indireto desses contaminantes pela população, por meio da ingestão de plantas contaminadas. Palavras-chave: Contaminantes emergentes. Hormônios. Saúde humana.Abstract: Postmodern society uses various substances to improve their quality of life. Many of these substances are drugs and many of these are already considered emerging contaminants and present in various locations due to human action. There is a concern of the international scientific community to monitor emerging contaminants and establish quantification protocols that may establish tolerance limits of these substances and thus protect human communities from possible health problems resulting from this contamination. There is evidence of numerous emerging contaminants (antimicrobials, fungicides, hormones, anti-inflammatory drugs) in surface waters and foods. The aim of this study was to evaluate the presence of progesterone in tissues of lettuce (Lactuca sp.) by ultraviolet spectroscopy (UV). The plants were grown in vitro and tested against different concentrations of progesterone (5,10,100 and 1000 ppm). The part of the plant collected for analysis was the leaves. It was used as solvent the ethanol 92.8 o GL. It was detected the presence of progesterone after the interval of a day of substrate contamination until the eighth day, and the concentrations found were between 0,14 and 1,11 ppm in the ethanol extract of the leaves. This study indicates the potential contamination of plants, when they are irrigated with water from water sources contaminated with progesterone and its m...

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“…In wheat, progesterone concentration varied by variety, age, stage of growth, and drought status, suggesting a role in the growth and development of the crop (Janeczko et al, 2013). As further evidence that progesterone has a biological effect in plants, the same group found that the 3β-hydroxysteroid dehydrogenase (3βHSD) inhibitor, trilostane, reduced free progesterone concentrations in wheat seedlings, evidencing its efficacy in plants (Janeczko et al, 2015). Trilostane reduced ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activity in wheat seedlings grown in drought conditions, and exogenous progesterone reversed the effect (Janeczko et al, 2015).…”

Section: Phytoprogestinsmentioning

confidence: 99%

“…As further evidence that progesterone has a biological effect in plants, the same group found that the 3β-hydroxysteroid dehydrogenase (3βHSD) inhibitor, trilostane, reduced free progesterone concentrations in wheat seedlings, evidencing its efficacy in plants (Janeczko et al, 2015). Trilostane reduced ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activity in wheat seedlings grown in drought conditions, and exogenous progesterone reversed the effect (Janeczko et al, 2015). These investigations clearly demonstrated that plants produced progesterone, and suggested that progesterone may regulate plant growth.…”

Section: Phytoprogestinsmentioning

confidence: 99%

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Dean¹,

Murphy²,

Burdette³

2017

Molecular and Cellular Endocrinology

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Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids – chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4-[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements.

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Disturbances in production of progesterone and their implications in plant studies

Cited by 24 publications

References 54 publications

Roles of Brassinosteroids in Plant Reproduction

Roles of Brassinosteroids in Plant Reproduction

Detecção De Progesterona Em Tecidos Vegetais De Lactuca Sp. Por Espectroscopia De Uv

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

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