Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings

Maksimova, M. Yu.; Ivanov, Alexander; Virus, Edward Danielevich; Александрин, В. В.; Nikiforova, Ksenia; Булгакова, Полина Олеговна; Ochtova, Fatima Ramazanovna; Suanova, Ekaterina Taymurazovna; Piradov, М. А.; Кубатиев, Аслан Амирханович

doi:10.1016/j.clineuro.2019.105393

Cited by 15 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GSH and Hcy levels were determined by liquid chromatography as described in a previous study [ 33 ]. SAM and SAH levels were determined by liquid chromatography–fluorescence detection as described in a previous study, with some modifications [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Kryukov¹,

Ivanov

Karpov³

et al. 2021

Disease Markers

Self Cite

View full text Add to dashboard Cite

Objective. S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19. Methods. The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 ( n = 56 , mean age = 61 ). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification. Results. SAM was found to be a potential marker of lung damage risk in COVID-19 patients ( SAM > 80 nM ; CT3,4 vs. CT 0-2: relative ratio (RR) was 3.0; p = 0.0029 ). SAM / SAH > 6.0 was also found to be a marker of lung injury (CT2-4 vs. CT0,1: RR = 3.47 , p = 0.0004 ). There was a negative association between SAM and glutathione level ( ρ = − 0.343 , p = 0.011 ). Interleukin-6 (IL-6) levels were associated with SAM ( ρ = 0.44 , p = 0.01 ) and SAH ( ρ = 0.534 , p = 0.001 ) levels. Conclusions. A high SAM level and high methylation index are associated with the risk of lung injury in patients with COVID-19. The association of SAM with IL-6 and glutathione indicates an important role of transmethylation in the development of cytokine imbalance and oxidative stress in patients with COVID-19.

show abstract

Section: Methodsmentioning

confidence: 99%

Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Kryukov¹,

Ivanov

Karpov³

et al. 2021

Disease Markers

Self Cite

View full text Add to dashboard Cite

show abstract

“…GSH and Hcy levels were determined by liquid chromatography as described in a previous study [25]. SAM and SAH levels were determined by liquid chromatography -fluorescence detection as described in a previous study, with some modifications [26].…”

Section: Laboratory Proceduresmentioning

confidence: 99%

Plasma S-Adenosylmethionine is Associated with Lung Injury in COVID-19

Kryukov¹,

Ivanov

Karpov³

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19. Methods: The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 (n = 56, mean age = 61). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification. Results: SAM was found to be a potential marker of lung damage risk in COVID-19 patients (SAM > 80 nM; CT3,4 vs. CT 0-2: relative ratio (RR) was 3.0; p = 0.0029). SAM/SAH > 6.0 was also found to be a marker of lung injury (CT2-4 vs. CT0,1: RR = 3.47, p = 0.0004). Interleukin-6 (IL-6) levels were associated with SAM (r= 0.44, p = 0.01) and SAH (r= 0.534, p = 0.001) levels. Conclusions: High SAM levels and high methylation index are associated with the risk of lung injury in COVID-19 patients. The association of SAM and SAH with IL-6 indicates an important role of transmethylation in the development of cytokine imbalance in COVID-19 cases.

show abstract

“…Thiol-disulfide homeostasis can be affected very rapidly from oxidative changes, and oxygen radicals are likely to alter hemostasis. In cases where hypoxia or ischemia is possible, blood thiol-disulfide levels of the patient provide valuable information about the state of oxidative stress (9,10). The aim of this study was to evaluate the effects of oxidative stress caused by hypotensive anesthesia on thiol-disulfide homeostasis in mastoidectomy-tympanoplasty cases undergoing controlled hypotension with remifentanil.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

Döğer

Özcan

Erkılıç³

et al. 2021

Clinical and Experimental Health Sciences

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the effects of oxidative stress on thiol-disulfide homeostasis caused by hypotensive anesthesia in mastoidectomy-tympanoplasty cases undergoing controlled hypotension.Methods: Fifty adult patients scheduled for mastoidectomy and tympanoplasty were included in the study. Anesthesia was induced with lidocaine, propofol, rocuronium, and remifentanil. The maintenance of anesthesia was continued with remifentanil infusion (target mean arterial pressure as 60-65 mmHg) along with 2% sevoflurane/40% O2/air mixture. Blood samples were taken 5 times at the t0 (before induction), t1 (intraoperatively after intubation), t2 (first hour) and t3 (second hour of the operation) and t4 (following recovery). Total thiol (TT) and Native Thiol (NT) levels were measured, and thus, Di-Sulphide (SS), Di-Sulphide/Native Thiol (SSNT), Di-Sulphide/Total Thiol (SSTT), and Native Thiol/ Total Thiol (NTTT) values were estimated.Results: During the operation, progressive decrease was observed in thiol levels of patients. There was a significant decrease in t3 thiol values when compared with t0 value. Thiol values were observed to have returned to baseline values after recovery from anesthesia (p>0.05). SS, SSNT and SSTT levels were found as increased in t1 blood samples, but increase in SSNT and SSTT levels was significant. Throughout the operation, values were observed to have dropped and reverted back to initial values. Conclusion:Since the measurement of thiol-disulfide blood values is able to show the instantaneous state of oxidative stress, it can be used in anesthesia practice in which every event occurs very quickly.

show abstract

Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings

Cited by 15 publications

References 44 publications

Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Plasma S-Adenosylmethionine is Associated with Lung Injury in COVID-19

Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

Contact Info

Product

Resources

About