Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum

Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observ.ed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell-mediated immunity, which also may be genetically determined, played an important role in the expression of this disease. Cancer 3 9 : 1 2 29-1 23 6, 19 7 7. ITH T H E RECOGNITION OF INCREASED FRE-W quency of malignancy in patients with immune deficiency, attention has been directed to the study of immunologic functions in family members and patients with various familial car-cinomas and lymphoproliferative disorders. It has been shown recently that subclinical immune defects were present in healthy relatives of patients with familial gastric cancer, non-Hodgkin's lymphoma, '' and chronic lymphocy

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Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

Wanebo¹,

Rao²,

Attiyeh³

et al. 1980

Cancer

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The concept whether immune reactivity was intrinsically related to risk of recurrence was examined in 307 patients with rectal colon cancer, including 181 patients with primary resectable cancer, 48 patients with advanced primary operable cancer, and 78 patients with recurrence. Immune reactivity was measured by 2,4-dinitrochlorobenzene (DNCB) skin tests (219 patients) and by in vitro immunoparameters (1 10 patients) including lymphocyte levels and lymphocyte stimulation tests with mitogens and antigens. There was a linear depression of immune reactivity as measured by DNCB, phytohemagglutinin (PHA) response, and lymphocyte count with increasing stage of disease (P < -05). Immunity was depressed even in patients with Dukes' A cancer (24% were DNCB negative, 33% had low PHA) and was more depressed in patients with Dukes' Band C lesions (40% were DNCB negative, 30% had low PHA), but was profoundly depressed in patients with advanced primary cancer or recurrence (60% had depression of DNCB, PHA, and lymphocyte counts).Short-term prognosis was examined according to DNCB, lymphocyte count, and mitogen responses in patients with resected Dukes' A, B, and C cancers. There was no correlation of recurrence rates in Dukes' C patients with DNCB, lymphocyte count, or the mitogens PHA, Con A o r pokeweed mitogen (PWM). In contrast, tests with CEA have shown a significant correlation of elevated levels with increased recurrence rates in patients with Dukes' C. There were no correlations of any of the immune tests with recurrence rates in Dukes' A or B, although the follow-up is still short (median 48 months), and the median diseasefree survival has not yet been reached. Only patients with advanced disease (liver metastases) showed correlation of immune responses (PHA and lymphocyte count but not DNCB) with survival, P < .05.

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Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum

Cited by 12 publications

References 17 publications

Phytohemagglutinin-Stimulated Immune Response

Phytohemagglutinin-Stimulated Immune Response

Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies.II. Chromosomal and immunologic abnormalities

Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

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