Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus

Jirikowski, Gustav F.; Kauntzer, Ulrike W.; Dief, Abeer E.; Caldwell, Jack D.

doi:10.1007/s00418-008-0540-6

Cited by 36 publications

(23 citation statements)

References 18 publications

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“…Using the same antibodies, we also stained the brains of 6-month-old 5XFAD mice and observed that DBP coincides with Ab in the frontal cortex of 5XFAD mice (Figure 3b). Consistent with a previous report using same DBP antibody (H300: sc-32899; Santa Cruz Biotechnology, Santa Cruz, CA, USA), 18 DBPexpressing cells were detected in the hypothalamus of 6-month-old 5XFAD mice, demonstrating the specificity of DBP immunoreactivity (Supplementary Figure 1). Ab accumulation was not detectable in the hypothalamus of 6-month-old 5XFAD mice.…”

Section: Resultssupporting

confidence: 91%

Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

et al. 2012

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The level of vitamin D-binding protein (DBP) is increased in the cerebrospinal fluid of patients with Alzheimer's disease (AD), suggesting a relationship with its pathogenesis. In this study, we investigated whether and how DBP is related to AD using several different approaches. A pull-down assay and a surface plasmon resonance binding assay indicated direct interactions between purified DBP and amyloid beta (Ab), which was confirmed in the brain of AD patients and transgenic AD model mice by immunoprecipitation assay and immunohistochemical double-staining method. Moreover, atomic force microscopic examination revealed that DBP reduced Ab aggregation in vitro. DBP also prevented Ab-mediated death in cultured mouse hippocampal HT22 cell line. Finally, DBP decreased Ab-induced synaptic loss in the hippocampus and rescued memory deficits in mice after injection of Ab into the lateral ventricle. These results provide converging evidence that DBP attenuates the harmful effects of Ab by a direct interaction, and suggest that DBP is a promising therapeutic agent for the treatment of AD.

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Section: Resultssupporting

confidence: 91%

Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

et al. 2012

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“…The strongest immunohistochemical staining for both the receptor and enzyme was noted in the hypothalamus (and substantia nigra.). Recently, Jirikowski et al [63] studied immunostaining for vitamin D-binding protein (DBP) in rat hypothalamus. DBP was observed in widespread axonal projections throughout the lateral hypothalamus [63].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?

et al. 2010

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According to recent observations, there is worldwide vitamin D insufficiency (VDI) in various populations. A number of observations suggest a link between low serum levels of vitamin D and higher incidence of chronic pain. A few case reports have shown a beneficial effect of vitamin D therapy in patients with headache disorders. Serum vitamin D level shows a strong correlation with the latitude. Here, we review the literature to delineate a relation of prevalence rate of headaches with the latitude. We noted a significant relation between the prevalence of both tension-type headache and migraine with the latitude. There was a tendency for headache prevalence to increase with increasing latitude. The relation was more obvious for the lifetime prevalence for both migraine and tension-type headache. One year prevalence for migraine was also higher at higher latitude. There were limited studies on the seasonal variation of headache disorders. However, available data indicate increased frequency of headache attacks in autumn–winter and least attacks in summer. This profile of headache matches with the seasonal variations of serum vitamin D levels. The presence of vitamin D receptor, 1α-hydroxylase and vitamin D-binding protein in the hypothalamus further suggest a role of vitamin D deficiency in the generation of head pain.

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“…Recent discovery of vitamin D receptors in rodent [58] and human hypothalamus [59] indicates that vitamin D may affect hypothalamic function or serve as central neuroactive substance. The possibility that vitamin D deficiency contributes to AD pathology, hypothalamicdysfunction and subsequent bone loss should be explored in the future studies.…”

Section: Discussionmentioning

confidence: 99%

Reduced Limbic and Hypothalamic Volumes Correlate with Bone Density in Early Alzheimer's Disease

Loskutova

Honea

Brooks

et al. 2010

JAD

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Accelerated bone loss is associated with Alzheimer's disease (AD). Although the central nervous system plays a direct role in regulating bone mass, primarily through the actions of the hypothalamus, there is little work investigating the possible role of neurodegeneration in bone loss. In this cross-sectional study, we examined the association between bone mineral density (BMD) and neuroimaging markers of neurodegeneration (i.e., global and regional measures of brain volume) in early AD and non-demented aging. Fifty-five non-demented and 63 early AD participants underwent standard neurological and neuropsychological assessment, structural MRI scanning, and dual energy x-ray absorptiometry. In early AD, voxel-based morphometry analyses demonstrated that low BMD was associated with low volume in limbic grey matter (GM) including the hypothalamus, cingulate, and parahippocampal gyri and in the left superior temporal gyrus and left inferior parietal cortex. No relationship between BMD and regional GM volume was found in non-demented controls. The hypothesis-driven region of interest analysis further isolating the hypothalamus demonstrated a positive relationship between BMD and hypothalamic volume after controlling for age and gender in the early AD group but not in non-demented controls. These results demonstrate that lower BMD is associated with lower hypothalamic volume in early AD, suggesting that central mechanisms of bone remodeling may be disrupted by neurodegeneration.

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Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus

Cited by 36 publications

References 18 publications

Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?

Reduced Limbic and Hypothalamic Volumes Correlate with Bone Density in Early Alzheimer's Disease

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