Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

Abstract

BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

An Overview of Ovarian Tumours at B.P. Koirala Memorial Cancer Hospital, Nepal

“…More than half of the bilateral cases were malignant. 2 Similar to other studies, our study also found that benign serous cystadenomas were the most common type of benign ovarian tumours followed by mucinous cystadenomas accounting 38.6% and 22.5% respectively.…”

“…Strikingly, the overall 5-year relative survival rate generally ranges between 30%-40% across the globe and has seen only very modest increases (2%-4%) since 1995. 2 The comprehensive global cancer statistics from the International Agency for Research on Cancer indicate that gynecological cancers accounted for 19% of the…”

Histopathological classification of ovarian neoplasm: a retrospective study of 612 cases from a regional cancer centre, Odisha, India

“…This was in agreement with the study done by Sharadha et al, Gupta et al, Kar et al, and Mondal et al 4,6,11,12 But in other studies granulosa cell tumors were recorded as most predominant malignant type by Swamy et al, and endometroid carcinomas was found to be the most common ovarian malignancies by Yasmin et al 14,15 In a previous study the incidence of borderline tumors were 5.18% among all neoplastic tumors. 11 This was similar with this result but Mondal et al, found the higher incidence of borderline tumor in their study (7.31%). 6 Borderline tumor can be classified histologically according to their epithelial characteristics as serous, mucinous, endometrioid, clear cell or Brenner tumors.…”

“…In this study serous cystadenoma formed the commonest benign tumor among all benign tumor followed by mucinous cystadenoma which was similar with the recent study findings. 11 But in another study from Bhutan, mature cystic teratoma was found to be the most common type (61.6%) followed by serous cystadenoma. 13 Among malignant tumor, serous cystadenocarcinoma consisted of maximum.…”

“…10 In this study, malignant morphology comprised of highest percentage among all neoplastic tumor but in other study report from this country as well as western part of the globe, benign tumor found to be the highest numbers. 4,6,11,12 The high incidence of malignant tumor in this study could have been due to referral bias since this study was conducted in a regional cancer centre. In other hand, further complete research is needed to elucidate region specific factors behind the high incidence of ovarian malignancy in this area.…”