Distribution of tumor-associated antigens in the various histologic components of germ cell tumors of the testis

Immunohistochemical and Radioimmunological Determination of β-HCG and Pregnancy-Specific β₁_-Protein in Seminomas

“…The presence of HCG in seminomas has been con firmed by both radioimmunological [2,13,14,16,18,23] and immunohistochemical studies [2,12,14,18,30].…”

Teratomas and Allied Germ Cell Tumors: Common Origin and Diverging Paths of Differentiation

“…In addition, peridesmosomal tonofilaments and intracytoplasmic bundles, consistent with keratin production, are usually seen in EC cells cultured in vitro [Damjanov and Andrews, 1983]. EC cells occasionally contain the following sub stances: aFP [Kurman and Norris, 1976b;Kurman et al, 1977;Jacobsen et al, 1981;Morinaga et al, 1983;Nakakuma et al, Maiorana et al, 1984;Okamoto, 1986], G]AT [Jacobsen et al, 1981;Maio rana et al, 1984], lactate dehydrogenase isoenzyme 1 [Murakami and Said, 1984], ferritin [Jacobsen et al, 1981;Maiorana et al, 1984], HCG [Kurman and Norris, 1976b;Kurman et al, 1977;Morinaga et al, 1983;Nakakuma et al, 1983;Maiorana et al, 1984;Wold et al, 1984] and vimentin [Miettinen et al, 1985]. Nonetheless, vimen tin was not demonstrated in the EC series of Ramaekers et al [ 1985], nor was HCG in the EC series of Jacobsen et al [1981].…”

“…EC cells occasionally contain the following sub stances: aFP [Kurman and Norris, 1976b;Kurman et al, 1977;Jacobsen et al, 1981;Morinaga et al, 1983;Nakakuma et al, Maiorana et al, 1984;Okamoto, 1986], G]AT [Jacobsen et al, 1981;Maio rana et al, 1984], lactate dehydrogenase isoenzyme 1 [Murakami and Said, 1984], ferritin [Jacobsen et al, 1981;Maiorana et al, 1984], HCG [Kurman and Norris, 1976b;Kurman et al, 1977;Morinaga et al, 1983;Nakakuma et al, 1983;Maiorana et al, 1984;Wold et al, 1984] and vimentin [Miettinen et al, 1985]. Nonetheless, vimen tin was not demonstrated in the EC series of Ramaekers et al [ 1985], nor was HCG in the EC series of Jacobsen et al [1981]. The immunohistochemical demonstration of aFP in the areas where basement-mem brane-like material similar to that of orga noid structures of YSTs is seen has suggested that a vitelline component could be present in EC [Okamoto, 1986], Alkaline phosphatase with all or part of the characteristics of its placental isoen zymes was absent from the series of EC stud ied by Uchida et al [1981], but was identi fied by Paiva et al [ 1983] and by Manivel et al [1987] in some of their cases.…”

“…Their finding in several cases of EC has supported the view that this tumor might be constituted of tissue al ready committed to extraembryonic differ entiation [Takei and Pearl, 1981;von Hochstetter and Hedinger, 1982;Risdon. 1983], Jacobsen et al [1981] suggest that aFP could be found in the EC cells that represent the undifferentiated multipoten tial subpopulation with the ability, among others, to develop extraembryonic struc tures, including yolk sac. Incidentally, as early as 1974.…”

Clinical Usefulness of Serum Ferritin Measurements in Patients with Testicular Germ Cell Tumors

“…Another marker, ferritin, has been initially demon strated by indirect immunofluorescence in cells of embryonal carcinoma and immature teratoma [4] and later by indirect immunoperoxidase staining in cells of seminoma and some nonseminomatous tumors: cmbryonal carcinoma, yolk sac tumor, and teratoma [5,6], This marker has not been found in choriocar cinoma and syncytiotrophoblastic giant cells [6], Elevated concentrations of ferritin in serum have been observed in patients with embryonal carcinoma, teratoma and yolk sac tumor [4,7,8], and regarded as an adjunct marker to hCG and AFP [7,8]. On the contrary, other workers have claimed [9] that ferritin concentrations in serum cannot discriminate among histological tumor types or tumor stages, and are influenced by hepatic factors and anemia more than by the tumor itself.…”