Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker

Watanabe, Tetsu; Taguchi, Yoshitaka; Shiosaka, Sadao; Tanaka, Junya; Kumakura, Hiroaki; Terano, Yoshitake; Tohyama, Masaya; Wada, Hiroshi

doi:10.1016/0006-8993(84)90811-4

Cited by 797 publications

(326 citation statements)

References 28 publications

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“…Histamine is also released by activation of heteroreceptors (Hill and Straw, 1988;Gulat-Marnay et al, 1989a, 1990Prast et al, 1991;Ono et al, 1992;Chikai et al, 1994;Laitinen et al, 1995). Histaminergic neurons are concentrated in the tuberomammillary nucleus of the posterior basal hypothalamus (Panula et al, 1984;Watanabe et al, 1984) and project to various brain regions (Inagaki et al, 1988;Panula et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Bongers

Leurs

Robertson

et al. 2003

Neuropsychopharmacol

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Increasing evidence supports a role for histamine as a neurotransmitter and neuromodulator in emotion and cognition. The H 3 receptor was first characterized as an autoreceptor that modulates histamine release and synthesis via negative feedback. Mice deficient in apoE (Apoe -/-) have been used to define the role of apoE in brain function. In the present study, we investigated the possible role of histamine H 3 -receptor-mediated signaling in anxiety and cognition in mice Apoe -/-and wild-type mice. H 3 antagonists increased measures of anxiety in wild-type, but not Apoe -/-, mice. In contrast, H 3 antagonists similarly impaired object recognition in wild-type and Apoe -/-mice. In Apoe -/-mice, reduced negative feedback via H 3 receptors could contribute to increased signaling of H 1 receptors. Apoe -/-mice showed higher sensitivity to the anxiety-reducing effects of the H 1 receptor antagonist mepyramine than wild-type mice. These effects were dissociated from effects of mepyramine on the HPA axis. Compared to saline controls, mepyramine reduced plasma ACTH and corticosterone levels in wild-type, but not Apoe -/-, mice. These data support a role for apoE in H 3 receptor signaling. H 3 antagonists were proposed as a treatment for cognitive disorders such as Alzheimer's disease, which is associated with increased anxiety and cognitive impairments. As H 3 antagonists increase measures of anxiety and impair object recognition in wild-type mice, the use of H 3 antagonists in cognitive disorders may be counterproductive and should be carefully evaluated.

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Section: Introductionmentioning

confidence: 99%

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Bongers

Leurs

Robertson

et al. 2003

Neuropsychopharmacol

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show abstract

“…The hippocampus was chosen to examine the modulation of the SS receptor/effector system due to the high concentration of SS and its receptors [21,40] in spite of the moderate density of histaminergic fibers [33,53] present in this brain area. This moderate density of histaminergic fibers may explain the fact that changes in the somatostatinergic system were only observed at the highest dose tested.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are several lines of evidence suggesting that SS can play a physiological role in the modulation of this limbic structure [54]. Since the hippocampus receives histaminergic innervation [33,53] and SS receptors are modulated by histamine, it is tempting to speculate that in the hippocampus, SS could be involved as a mediator of the effects of histamine on behaviors such as learning and memory. The importance of this observation for basic science and clinical research requires further exploration.…”

Section: Discussionmentioning

confidence: 99%

“…Centrally administered SS produces a dose-related decrease in histamine levels in the rat hippocampus [7]. Ample evidence exists for histaminergic projections to the hippocampus [33,53], a brain area rich in SS content and receptors [21,40]. These and other subcortical afferents could play a decisive role in the expression of long-term potentiation.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal somatostatin receptors and modulation of adenylyl cyclase activity in histamine-treated rats

Puebla

Rodrı́guez-Martı́n

Arilla

1996

Molecular Brain Research

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“…Cerebral histamine is a biogenic monoamine that does not cross the blood brain barrier (1) and is present in mast cells and neurons of the central nervous system (CNS). Much research has been done to investigate the influences of the central histaminergic system (CHS) on CNS functions.…”

Section: Introductionmentioning

confidence: 99%

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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We determined the effect of an H 1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H 1 receptor impairs it.

show abstract

Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker

Cited by 797 publications

References 28 publications

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Hippocampal somatostatin receptors and modulation of adenylyl cyclase activity in histamine-treated rats

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

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