Distribution of Some of the HL‐A System Lymphocyte Antigens in Mexicans

Gorodezky, Clara; Escobar‐Gutiérrez, Alejandro; Salazar-Mallén, M

doi:10.1111/j.1423-0410.1972.tb03832.x

Cited by 12 publications

(4 citation statements)

References 5 publications

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“…* As we were preparing this study for publication, the distribution of some HL-A antigens in three Mexican Indian populations was reported (Gorodezky et al 1972). As many first and second series antigens were not detected by the seven antisera used in that survey, we cannot compare the results with our data and those available for the other American Indian populations.…”

Section: Resultsmentioning

confidence: 86%

Genetic Structure of the HL‐A System in a Nahua Indian Population in Mexico

et al. 1973

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HL–A phenotype and gene frequencies are presented for a population sample of Nahua Indians from Mexico. These Indians showed restricted variability in the first and second segregant HL–A series as compared to Caucasian, Black and Mongoloid populations, thus resembling other American Indian populations. Determinants for HL–A2, HL–A9, W28 and W31 accounted for 95% of first series alleles. For the second series W16, W5 and W10 comprised 75% of all genetic determinants. This population sample is the only American Indian group so far studied with W16 as the most frequently occuring second series antigen. Disturbances in the Hardy‐Weinberg equilibrium for the second series may reflect racial admisture and an antigen which cross reacts with W5 and W15. When adjustments were made for sample size and selection of the extreme deviate delta value, no evidence of linkage disequilibrium was noted in this population. Thus far, all American Indian groups studied show restricted variability of the HL–A system; this may reflect the effects of natural selection.

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Section: Resultsmentioning

confidence: 86%

Genetic Structure of the HL‐A System in a Nahua Indian Population in Mexico

et al. 1973

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“…They included data of Indian groups inhabiting North, Central and South America, as well as some Mestizo populations. Very little has, however, been done on Mexican natives (Cann et al 1973, Gorodezky et al 1972. It is therefore interesting to find out how close the HLA pattern of the Nahuas is to other ethnologically related groups, like the Pima , Ensroth et al 1983), or Papago , Ensroth et al 1983).…”

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confidence: 99%

The HLA system in the prevalent Mexican Indian group: the Nahuas

Gorodezky¹,

Castro‐Escobar²,

Escobar‐Gutiérrez³

1985

Tissue Antigens

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Results of HLA‐A, B and C typing as well as haplotype frequencies in the Nahuas, who are the predominant Indian group in Mexico are presented. ABO and Rh blood groups show the genetic homogeneity of this population, since all of them were group O and Rh+. The most frequent antigens and haplotype are in general, the same as in some, but not all Amerindian tribes (Papago, Pimas, Zuñi from North America and Ixils from Guatemala). When‐compared to other Mongoloids, the HLA pattern is very close to the Japanese population. Antigens Bw39 and Cw4 look like markers of Nahuas and because Bw16 cells from four individuals could not be assigned either as Bw38 or Bw39, and 6 subjects did not type for any of the Bw22 splits, new subtypes of these antigens are probable.

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“…In a previous communication [5] we reported the frequencies of seven antigens of the HL-A system for the general (Spaniard-Indian) Mestizo population of Mexico City and for three linguistic groups of Mexican Indians. The present paper deals with similar studies performed in 100 cases of atopy and in 50 patients with leprosy, belonging mainly to the Mestizo population, in comparison with 200 samples from our general population.…”

Section: Introductionmentioning

confidence: 99%