Distribution of rotavirus genotypes in three Croatian regions among children ≤5 years of age (2012–2014)

Vrdoljak, Maja; Gužvinec, Marija; Trkulja, Vladimir; Butić, Iva; Ivić, Ivo; Krželj, Vjekoslav; Tonkić, Marija; Jungvirth, Marija Hegeduš; Pal, Marina Payerl; Tešović, Goran

doi:10.1016/j.ijid.2019.09.008

Cited by 8 publications

(7 citation statements)

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“…The low frequency of RVA G8 infections detected in the present study (0.6%; 2007–2020) agreed with data previously described in Brazil in both pre- (1%; 2005) [ 27 ] and post-RVA vaccine eras (0.5%; 2007–2012) [ 47 ]. They were also similar to that observed in other studies carried out in Croatia (0.1%; 2012–2014) [ 60 ] and Thailand (0.6%; 2003–2004) [ 61 ]. A relatively high prevalence of G8 RVA strains has, for decades, been commonly observed in African countries [ 62 , 63 , 64 , 65 , 66 ].…”

Section: Discussionsupporting

confidence: 91%

Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone

Medeiros

França

Viana

et al. 2023

Viruses

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Rotavirus (RVA) G8 is frequently detected in animals, but only occasionally in humans. G8 strains, however, are frequently documented in nations in Africa. Recently, an increase in G8 detection was observed outside Africa. The aims of the study were to monitor G8 infections in the Brazilian human population between 2007 and 2020, undertake the full-genotype characterization of the four G8P[4], six G8P[6] and two G8P[8] RVA strains and conduct phylogenetic analysis in order to understand their genetic diversity and evolution. A total of 12,978 specimens were screened for RVA using ELISA, PAGE, RT-PCR and Sanger sequencing. G8 genotype represented 0.6% (15/2434) of the entirely RVA-positive samples. G8P[4] comprised 33.3% (5/15), G8P[6] 46.7% (7/15) and G8P[8] 20% (3/15). All G8 strains showed a short RNA pattern. All twelve selected G8 strains displayed a DS-1-like genetic backbone. The whole-genotype analysis on a DS-1-like backbone identified four different genotype-linage constellations. According to VP7 analysis, the Brazilian G8P[8] strains with the DS-1-like backbone strains were derived from cattle and clustered with newly DS-1-like G1/G3/G9/G8P[8] strains and G2P[4] strains. Brazilian IAL-R193/2017/G8P[8] belonged to a VP1/R2.XI lineage and were grouped with bovine-like G8P[8] strains with the DS-1-like backbone strains detected in Asia. Otherwise, the Brazilian IAL-R558/2017/G8P[8] possess a “Distinct” VP1/R2 lineage never previously described and grouped apart from any of the DS-1-like reference strains. Collectively, our findings suggest that the Brazilian bovine-like G8P[8] strains with the DS-1-like backbone strains are continuously evolving and likely reassorting with local RVA strains rather than directly relating to imports from Asia. The Brazilian G8P[6]-DS-1-like strains have been reassorted with nearby co-circulating American strains of the same DS-1 genotype constellation. However, phylogenetic analyses revealed that these strains have some genetic origin from Africa. Finally, rather than being African-born, Brazilian G8P[4]-DS-1-like strains were likely imported from Europe. None of the Brazilian G8 strains examined here exhibited signs of recent zoonotic reassortment. G8 strains continued to be found in Brazil according to their intermittent and localized pattern, thus, does not suggest that a potential emergence is taking place in the country. Our research demonstrates the diversity of G8 RVA strains in Brazil and adds to the understanding of G8P[4]/P[6]/P[8] RVA genetic diversity and evolution on a global scale.

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Section: Discussionsupporting

confidence: 91%

Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone

Medeiros

França

Viana

et al. 2023

Viruses

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“…Two outer capsid proteins, VP7 (or G protein) and VP4 (or P protein) are considered to define the serotype; their coding genes are classified into multiple genotypes based on sequence diversity [2,3]. Currently, more than 36 G and 51 P types have been detected and at least 60 combinations have been identified from humans and other animals [4][5][6]. Globally, the most common G-P genotype combinations causing 90% infections in children were G1P [8], G2P [4], G3P [8], G4P [8], G9P [8], and G12P [8] [2,3].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genotype distribution of group A rotavirus circulating in Shanxi Province, China during 2015–2019

Zhao¹,

Shi

Meng³

et al. 2021

BMC Infect Dis

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Background Group A rotavirus (RVA), despite being a leading cause of gastroenteritis in infants and young children, is less studied in Shanxi Province, China. The current study was conducted to determine the prevalence and genetic characterization of RVA in hospitalized children younger than 10 years of age with the diagnosis of acute gastroenteritis in Shanxi Province, China. Methods A hospital-based active surveillance of rotavirus gastroenteritis was conducted at Children’s Hospital of Shanxi from Jan 1, 2015, through Dec 31, 2019. Rotavirus was detected in stool samples by real-time quantitative reverse transcription PCR (qRT-PCR). G- and P-genotypes were determined by reverse transcription PCR (RT-PCR) and nucleotide sequencing. Results A total of 961 children younger than 10 years of age was enrolled over the study period, of whom 183 (19.0%) were positive for RVA. The highest RVA-infection frequency (23.7%) was found among children aged 12–23 months, and the seasonal peak was in December. G9P[8] was most prevalent (76.0%), followed by G3P[8] (7.1%), G2P[4] (3.3%), G1P[8] (0.5%) and G9P[4] (0.5%). Conclusions These results report for the first time that RVA was one of the main causes of severe infectious gastroenteritis in children, and a high proportion of G9P[8] strains circulating in most areas of Shanxi Province. While the protective efficacy of the rotavirus vaccines has been demonstrated against G9P[8] strains, our results highlight that the dominant strains have not been effectively controlled in China.

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“…Although in none of these studies, the role of latitude has not been studied directly, comparison of their results shows that the pattern of the disease differs in different geographical districts (Vrdoljak et al 2019). On the other hand, the main focus of research on the epidemiology of rotavirus gastroenteritis in India has been to determine the genetic diversity of the common strains in children with acute diarrhea referred to the hospital or to determine the prevalence of the number of children with rotavirus diarrhea in different groups of ages have been (Gupta et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Potential impact of climate change on temperature and humidity related human health effects during extreme condition

Javadinejad

Dara

Jafary

2020

Saf. Extreme Environ.

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In this study, in addition to considering the two dominant climatic domains during extreme condition in the study area, temperature and humidity, and determining the correlation and correlation of these two factors with the prevalence of rotavirus gastroenteritis, a statistical model was proposed to predict the prevalence of the disease. Although this research, like many earlier studies, has been based on statistical data for a period of three years, according to its primary objectives, the short-term risk of the disease has been zoned using GIS software, and this point is new. The distinction between the present study and previous studies is considered. Previous studies did not consider the relationship between climate change and gastroenteritis GE. So, the purpose of this study was to investigate the correlation between the number of patients admitted in the hospital with symptoms of gastroenteritis GE and the monthly climatic variables of temperature and humidity of rotavirus, maximum, mean during extreme condition, at least in the city of Ahvaz, in three levels and its suburbs. The results showed a high prevalence of rotavirus infection in children in Ahvaz at low temperature. The maximum rotavirus activity was determined at 13°C. Also, the highest number of patients with symptoms of rotavirus gastroenteritis was observed in autumn and early winter. It is suggested that the results of this study should be considered in determining the timing of vaccination during extreme condition.

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Distribution of rotavirus genotypes in three Croatian regions among children ≤5 years of age (2012–2014)

Cited by 8 publications

References 40 publications

Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone

Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone

Prevalence and genotype distribution of group A rotavirus circulating in Shanxi Province, China during 2015–2019

Potential impact of climate change on temperature and humidity related human health effects during extreme condition

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