Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.

Rickert, Douglas E.; Dent, John G.; Cagen, Stuart Z.; McCormack, K. M.; Melrose, Patricia A.; Gibson, James E.

doi:10.1289/ehp.782363

Cited by 35 publications

(14 citation statements)

References 8 publications

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“…This resulted in a respective incidence of hepatocellular carcinomas of 41.4% and 67.8% after 2 yr. It is known that PBB passes through the placenta and is excreted in the milk of rats (Rickert et al, 1978). This study was done to determine whether PBB (200 mg/kg) administered to the dams twice during pregnancy (d 7 and 14) would result in hepatocellular carcinomas in the offspring.…”

Section: Introductionmentioning

confidence: 99%

Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats

Groce

Kimbrough

1984

Journal of Toxicology and Environmental Health

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Firemaster FF-1, a polybrominated biphenyl (PBB) mixture, was dissolved in corn oil and given as a dose of 200 mg/kg body weight to Sherman rats on d 7 and 14 of pregnancy. Control rats received equivalent doses of corn oil alone. Selected pups and all dams were killed 1 mo after pups were weaned. A total of 50 male and 50 female offspring per group were followed until they were 2 yr old. The livers of offspring killed at the ages of 2 mo and 2 yr had PBB levels of 2,4 (SD 1.2) and 0.8 (SD 0.65) mg/kg for females and 3.0 (SD 1.6) and 0.6 (SD 0.37) mg/kg for males, respectively. The incidence of hepatocellular carcinomas was 3/51 (5.9%) and 4/41 (9.6%) after 2 yr in females and males, respectively. Hepatocellular carcinomas were not observed among the controls. Neoplastic (hyperplastic) nodules of the liver were present in 9/51 (17.6%) and 2/41 (4.9%) of exposed females and males, respectively, whereas only 2/48 (4.2%) of control females and no control males had neoplastic (hyperplastic) nodules. Body weights were lower in PBB-exposed rats at ages 1, 6, 12, and 24 mo. Survival rates from birth to weaning were lower in PBB-exposed pups (89%) than in controls (98%). Mortality was two times higher in PBB-exposed males (64%) than in control males (32%) after 2 yr. Transplacental PBB exposure and exposure through milk resulted in PBB body burdens in the offspring still measurable at the end of their lifespan. These offspring had increased mortality rates and lower body weights than controls, and they developed hepatocellular carcinomas.

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Section: Introductionmentioning

confidence: 99%

Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats

Groce

Kimbrough

1984

Journal of Toxicology and Environmental Health

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“…Decay was sigificantly slower among women with an initial BMI at or above the median (BMI . 23 (4,10,11). The highest PBB concentrations in the body are found in adipose tissue, but it can also be detected at lower concentrations in serum and other lipid-rich tissues, such as the skin and liver.…”

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confidence: 99%

Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.

Blanck

Marcus²,

Hertzberg³

et al. 2000

Environ Health Perspect

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Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Seram was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination ofPBB and to identify factors associated with elimination. A total of 380 women 2 16 years of age who had an initial PBB level of 2 ppb and at least two serum samples drawn when they were not pregnant were induded in the analysis.The mean initial PBB level was 20.9 ppb (median 4) and mean time between the first and last measurement was 4.2 years (range 0.5-11.1). PBB was assumed to reach equilibrium in the body before substantial amounts were eliminated and before the first serum measurements were taken; therefore, the entire body was modeled as a single compartment for PBB with exponential decay.Subject-specific decay rate estimates were regressed on predictor variables icluding initial age, body mass index (BMI), smoking history, breast-feeding duration, and parity. In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the medi- (91; there-fore, the Michigan individuals were mainly exposed to virtually unchanged PBB153. In the absence of metabolism, elimination is a slow process. Some PBB is eliminated through feces and hair. In women, PBB can be eliminated through lactation. There is also evidence that some PBB is transferred to offspring during pregnancy (4,10,11). The highest PBB concentrations in the body are found in adipose tissue, but it can also be detected at lower concentrations in serum and other lipid-rich tissues, such as the skin and liver.There are two previous reports of serum PBB half-life in women. Both of these studies were conducted using data from the Michigan PBB cohort (12,13

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“…The decision-making with regard to which tests to use in the present study was as follows: the abilities examined by the three tests which load only onto the Motor Scale were already being tested by the pediatric neurologist, hence, it was unnecessary to repeat these. This left 15 Pearson product moment correlations between the natural logarithm transformations of the exposed children's fat PBB levels and their standardized scores on each of the five McCarthy Scales tests administered are presented in Table 1. The second through fifth rows in the table show the intercorrelations between the children's performances on the five tests.…”

Section: Methodsmentioning

confidence: 99%

Developmental abilities of children exposed to polybrominated biphenyls (PBB).

Seagull¹

1983

Am J Public Health

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correlations were significant at p < .05. Multivariate analysis of covariance confirmed the existence of a significant main effect for fat PBB level, with parental education held constant. Children with higher body burdens of PBB (> .100 ppm) scored significantly lower than exposed children with lower body burdens on the same four tests, and on a composite score representing overall performance. These results suggest the existence of an inverse relationship between body levels of PBB and some developmental abilities in young children. (Am J Public Health 1983; 73:28 1-285.)

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Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.

Cited by 35 publications

References 8 publications

Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats

Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats

Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.

Developmental abilities of children exposed to polybrominated biphenyls (PBB).

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