Distribution of persistent organochlorine pollutants in maternal and foetal tissues: Data from an Italian polluted urban area

Bergonzi, Roberto; Specchia, Cristina; Dinolfo, Mariadaniela; Tomasi, Cesare; Palma, Giuseppe De; Frusca, T.; Apostoli, Pietro

doi:10.1016/j.chemosphere.2009.05.026

Cited by 118 publications

(65 citation statements)

References 41 publications

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“…We have previously demonstrated (Bergonzi et al, 2009) that the maternal tissue levels of ΣPCBs, p,p′-DDE, and HCB were positively and significantly related to maternal age, thus confirming both the bio-persistence and the intake through diet of these OCs. Thus, higher fetal exposure to persistent organic pollutants can be considered as a further implication of advanced maternal age.…”

Section: Discussionmentioning

confidence: 81%

“…Distribution of OC levels in both maternal and fetal tissues and their correlations confirming the transplacental transfer of these compounds, have been already reported (Bergonzi et al, 2009). In four cases, the cord blood samples could not be tested for HCB levels.…”

Section: Organochlorine Levelsmentioning

confidence: 89%

“…We have already reported that the concentrations of ΣPCBs, p,p′-DDE and HCB in cord and maternal serum, as well as those in placenta and adipose tissue were positively and significantly correlated with maternal age (Bergonzi et al, 2009). …”

Section: Correlations Of Organochlorines With Maternal Characteristicsmentioning

confidence: 99%

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Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Bergonzi

Palma

Specchia

et al. 2011

Science of The Total Environment

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Section: Discussionmentioning

confidence: 81%

Section: Organochlorine Levelsmentioning

confidence: 89%

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Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Bergonzi

Palma

Specchia

et al. 2011

Science of The Total Environment

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“…It was observed that several EDCs are able to pass through the placenta to the fetus. Many recent studies were devoted to the transmittance of EDC and assessing their content in the cord blood serum and maternal adipose tissue [13][14][15][16][17][18][19][20][21][22][23][24][25][26], showing that a fetus and once born an infant may be exposed to significantly high levels of EDC [27]. This can result in a decrease in fetal birth weight, premature birth, psychomotor retardation and altered cognitive function [28][29][30][31][32][33].…”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Research trends on emerging environment pollutants – a review

Rykowska

Wasiak

2015

Open Chemistry

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Concern for the natural environment increasingly devotes more attention to growing potential hazards resulting from the release of various substances. Currently, one of the main problems associated with environmental pollution is the derivation of organic compounds from wastewater. Substances derived from sewage leaks into the environment in the form of a multicomponent mixtures often enhances the toxic effects caused by these compounds. While analyzing the reports in the literature of the last two decades it can be seen that substantial efforts are devoted to the determination of selected trace contaminants present in wastewater. Among the most marked there are endocrine disrupting compounds, residues of pharmaceuticals and personal care products, plastics and sunscreens. Recently, a new group of compounds joined the aforementioned contaminants, namely drugs, whose legality and availability is increasing every year. Exposure to these type of compounds, named in the literature as emerging contaminants (ECs), involves, among others, such effects as hormonal imbalance, reduction of the survivability of aquatic organisms and reproductive problems.This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the natural environment in many countries all around the world.

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“…This modeling enables an accurate description of the kinetics of PCBs, as blood or serum levels are usually higher in the mother than in the fetus. 30,50 The PBPK model was parameterized with values 45 and data sets 30 that are independent of our biomonitoring data. No inter-individual variability was modeled for the toxicokinetic processes.…”

Section: -1979mentioning

confidence: 99%

Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women

Ulaszewska

Ciffroy

Tahraoui

et al. 2012

J Expo Sci Environ Epidemiol

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Polychlorinated biphenyls (PCBs) are persistent contaminants suspected to cause adverse health effects in humans. As PCBs levels in food have not been monitored frequently in the past, modeling approaches based on environmental data have been proposed to predict the human dietary intake. In this work, we propose to improve these approaches by taking into account internal levels of PCBs in humans. This methodology is based on the analysis of biomonitoring data using exposure and physiologically based pharmacokinetic (PBPK) modeling to determine the most probable scenario of exposure. Breast milk concentrations were measured in Italian women for PCB-138, PCB-153 and PCB-180. For each congener, three exposure scenarios were derived and a PBPK model was used to relate the lifetime exposure to the breast milk levels. For the three PCBs, we determined the most probable scenario of exposure. Our results support the adequacy of the exposure and the PBPK models for PCB-180 and PCB-153, whereas we observed discrepancies between the models and the biomonitoring data for PCB-138. Our intake estimates are in good agreement with previous exposure assessments based solely on food contamination demonstrating the relevance of our approach to reconstruct accurately the exposure and to fill in data gaps on exposure.

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Distribution of persistent organochlorine pollutants in maternal and foetal tissues: Data from an Italian polluted urban area

Cited by 118 publications

References 41 publications

Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Research trends on emerging environment pollutants – a review

Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women

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