Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Bergonzi, Roberto; Palma, Giuseppe De; Specchia, Cristina; Dinolfo, Mariadaniela; Tomasi, Cesare; Frusca, T.; Apostoli, Pietro

doi:10.1016/j.scitotenv.2011.04.031

Cited by 44 publications

(16 citation statements)

References 42 publications

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“…The most important descriptors of behavior of these compounds in the body which have been studied are maternal age, education status, body height, pre-pregnancy weight, weight gain and BMI, gestational length, parity, diseases as diabetes, hypertension and preeclampsia, alcohol and smoking habits during pregnancy, maternal occupation, place of residence, fuel type used for cooking, and marital status. From newborn variables interactions with sex, weight, length, head circumference, and Apgar score were described (Glynn et al 2007; Llop, et al 2010; Hansen et al 2010; Adetona et al 2013; Bergonzi et al 2009; 2011; Freire et al 2011; Arrebola et al 2010; 2012a; 2012b; 2012c). To our knowledge, however, none of these determinants has so far been related to placental transfer of OCPs or PCBs.…”

Section: Discussionmentioning

confidence: 99%

“…Information on placental transfer of POPs is obtained when C is related to concentration in maternal blood (M) at the time of delivery. Data on concentration of OCPs and PCBs and some of its metabolites in cord and maternal blood can be found in literature (Adetona et al 2013; Porpora et al 2013; Butler Walker et al 2003; Bergonzi et al 2011; 2009; Covaci et al 2002; Tatsuta et al 2012; Tsukimori et al 2013a; 2013b; Nakano et al 2005; Suzuki et al 2005; Jacobson et al 1984; Sala et al 2001; Abballe et al 2008). In spite of this wealth of information, the knowledge on maternal anthropometric, socioeconomic, and health factors which influence the transfer of POPs through human placenta is limited.…”

Section: Introductionmentioning

confidence: 99%

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Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds

Patayová

Wimmerová

Lancz

et al. 2013

Environ Sci Pollut Res

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The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH) , p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123+149, 138+163, 153, 156+171, 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002–2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds

Patayová

Wimmerová

Lancz

et al. 2013

Environ Sci Pollut Res

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“…It was observed that several EDCs are able to pass through the placenta to the fetus. Many recent studies were devoted to the transmittance of EDC and assessing their content in the cord blood serum and maternal adipose tissue [13][14][15][16][17][18][19][20][21][22][23][24][25][26], showing that a fetus and once born an infant may be exposed to significantly high levels of EDC [27]. This can result in a decrease in fetal birth weight, premature birth, psychomotor retardation and altered cognitive function [28][29][30][31][32][33].…”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Research trends on emerging environment pollutants – a review

Rykowska

Wasiak

2015

Open Chemistry

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Concern for the natural environment increasingly devotes more attention to growing potential hazards resulting from the release of various substances. Currently, one of the main problems associated with environmental pollution is the derivation of organic compounds from wastewater. Substances derived from sewage leaks into the environment in the form of a multicomponent mixtures often enhances the toxic effects caused by these compounds. While analyzing the reports in the literature of the last two decades it can be seen that substantial efforts are devoted to the determination of selected trace contaminants present in wastewater. Among the most marked there are endocrine disrupting compounds, residues of pharmaceuticals and personal care products, plastics and sunscreens. Recently, a new group of compounds joined the aforementioned contaminants, namely drugs, whose legality and availability is increasing every year. Exposure to these type of compounds, named in the literature as emerging contaminants (ECs), involves, among others, such effects as hormonal imbalance, reduction of the survivability of aquatic organisms and reproductive problems.This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the natural environment in many countries all around the world.

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“…In view of the increasing prevalence of overweight and obesity among childbearing women, the Institute of Medicine (IOM) has provided specific recommendations for GWG, and has stated the need for research on possible relationships between environmental exposures and GWG (IOM 2009). Associations between prenatal POP exposures and birth weight (Govarts et al 2012; Lopez-Espinosa et al 2011), early obesity (Valvi et al 2012), and preterm birth (Bergonzi et al 2011) have been reported. Given these findings, further knowledge is needed to assess the importance of GWG on newborn POP concentrations.…”

Section: Introductionmentioning

confidence: 99%

Gestational Weight Gain and Exposure of Newborns to Persistent Organic Pollutants

Vizcaino

Grimalt

Glomstad

et al. 2014

Environ Health Perspect

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Background: Exposure to persistent organic pollutants (POPs) during fetal development can increase the risk of adverse health effects during childhood. Maternal characteristics and physiological changes during gestation, such as gestational weight gain (GWG), may have an influence in the overall burden of POPs in neonates. However, the associations between GWG and POP concentrations are still not well established.Objective: We examined the association of GWG with cord serum POPs concentrations after adjusting for prepregnancy maternal body mass index (BMI) and other potential determinants of the transfer of POPs into newborns. The GWG values were evaluated after grouping by the reference guidelines of the Institute of Medicine (IOM).Methods: We measured levels of 14 organochlorine pesticides, 7 polychlorobiphenyls (PCBs), and 14 polybrominated diphenyl ethers (PBDEs) in 325 cord serum samples from a Spanish birth cohort. Multivariable models were used to estimate associations of GWG, prepregnancy BMI, and other maternal determinants on cord serum concentrations of POPs.Results: Neonatal concentrations of POPs were inversely associated with GWG after adjustment for age, prepregnancy BMI, educational level, and fish consumption. On average, neonates of women with IOM-recommended GWG have lower POP concentrations than do neonates of mothers with inadequate GWG.Conclusions: The present findings suggest an association between neonatal exposure to POPs and inadequate GWG during pregnancy. Encouraging pregnant women to meet the recommended IOM guidelines for GWG may reduce the accumulation of POPs in newborns.Citation: Vizcaino E, Grimalt JO, Glomstad B, Fernández-Somoano A, Tardón A. 2014. Gestational weight gain and exposure of newborns to persistent organic pollutants. Environ Health Perspect 122:873–879; http://dx.doi.org/10.1289/ehp.1306758

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Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Cited by 44 publications

References 42 publications

Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds

Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds

Research trends on emerging environment pollutants – a review

Gestational Weight Gain and Exposure of Newborns to Persistent Organic Pollutants

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