Distribution of p,p'-DDT residues in adipose and muscle tissues of beef cattle

Rumsey, T. S.; Putnam, P. A.; Davis, R. E.; Corley, Calvin

doi:10.1021/jf60153a024

Cited by 24 publications

(17 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results are appreciably identical to those in the previous investigation (Deichmann, 1972) and support the fact that the liver is the main organ where DDT is transformed into DDD (Radomski et al, 1968;Rumsey et al, 1967;Lambert and Brodeur, 1976;Alary et al, 1971). In addition, it was also reported that DDD was detected only in the liver of laying hens after a single oral administration of p,p'-DDT (Furusawa, 2002).…”

Section: Discussionsupporting

confidence: 86%

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

et al. 2003

View full text Add to dashboard Cite

-A comparative study on the reliability of toxicokinetic parameters for predicting hepatotoxicity was conducted in male F344 rats receiving a single (106 mg/kg by gavage) or 7-day repeated (1000 ppm in feed, 97 mg/kg/day) administration of p,p'-DDT. DDT was selected as the test substance because it is known as a hepatotoxic agent and its metabolic pathway is well documented. Concentrations of DDT and its metabolites (DDE and DDD) in the plasma, brain, and liver were measured at various time intervals during the study and the results were compared with the area under the concentration-time curve (AUC) in relation to hepatotoxic response. Increases in the absolute and relative (ratio to body weight) liver weights were observed as a typical toxic response after a single or repeated exposure to DDT. The coefficient (R 2 ) of correlation between the increases in the relative liver weight and the concentrations or AUC of DDT and its metabolites in the plasma and liver was estimated. The values of R 2 between the relative liver weight and AUC of DDT or the total DDT (T-DDT) in the plasma and liver were found to be more consistent and higher than those with their concentrations in the repeated dose study. In addition, the R 2 values in correlation with their AUCs after a single exposure were lower than those in the repeated dose study. These results indicate that the AUC of DDT or T-DDT in the plasma and liver would be more reliable than their concentrations for predicting hepatotoxicity caused by DDT, especially in the repeated dose study.

show abstract

Section: Discussionsupporting

confidence: 86%

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

et al. 2003

View full text Add to dashboard Cite

show abstract

“…It was reported in rats treated with DDT that DDD tended to accumulate in the liver at the same rate/level as DDT, while DDE was quantitatively of lesser amount (Mitjavila et al, 1981). The results are appreciably identical to those in the previous investigation (Deichmann, 1972) and support the fact that the liver is the main organ where DDT is transformed into DDD (Alary et al, 1971;Lambert and Brodeur, 1976;Radomski et al, 1968;Rumsey et al, 1967).…”

Section: Discussionsupporting

confidence: 82%

A Further Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity in Rats Receiving a 28-Day Repeated Administration of DDT

et al. 2004

View full text Add to dashboard Cite

-We previously demonstrated a good correlation between the increased relative liver weight caused by DDT and the area under the concentration-time curve (AUC) of DDT or the total DDT (T-DDT) in plasma and liver of rats in a 7-day repeated dose study at 1000 ppm. To confirm the reliability of AUC for predicting toxic responses at different dose levels, we conducted a further 28-day repeated dose study of p,p'-DDT in male F344 rats at dietary levels of 50, 160, and 500 ppm. Concentrations of DDT and its metabolites in plasma, brain, liver, and fat for each dose group were measured at various time intervals during the study. The concentrations of DDT and T-DDT in plasma and liver were compared with their AUCs in relation to hepatotoxic responses including increased relative liver weight, microsomal enzyme induction (CYP2B1), and inhibition of gap junctional intercellular communication. The coefficient (R 2 ) values of each toxic response in correlation with AUCs were generally much higher than those with concentrations at any dose levels, although the R 2 values vary considerably among toxic parameters. These results have confirmed that the AUC of DDT or T-DDT in plasma or liver is a reliable marker for predicting hepatotoxicity caused by DDT in repeated dose studies.

show abstract

“…Studies along these lines have been carried out with beef cattle and dairy cows (McCulley, Villeneuve, McKinley, Phillips, and Hidiroglou 1966;Fries and Kane 1967;Rumsey, Putnam, Davis, and Corley 1967). The present trials were designed to obtain similar data for sheep.…”

Section: Nz Journal Oj Agriculturalmentioning

confidence: 99%

“…DDTt adminstered orally to cattle and sheep is partly converted to DDEt and DDDt, which accumulate with unchanged DDT in adipose tissue (Rumsey, Putnam, Davis, and Corley 1967;Fries and Kane 1967;Harrison and Mol 1968). However, domestic stock are unlikely to be exposed solely to DDT in their diet, because residues in animal feedstuffs and in farm topsoils resulting from the use of technical DDT usually comprise mixtures of the two DDT isomers together with DDE * Wallaceville Animal Research Centre, Department of Agriculture, P.B., Wellington, New Zealand.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of DDE, DDD, and DDT in sheep

Hunnego¹,

Harrison²

1971

New Zealand Journal of Agricultural Research

View full text Add to dashboard Cite

Sheep were dosed orally for 28 consecutive days with DDE, DDD, or DDT individually, or with a mixture of these three compounds. In a second similar trial DDE was administered either alone or simultaneously with DDD and/or DDT. The dose rate for each compound in all cases was 1 mg pp'-isomer/kg body weight/day. All sheep were sampled for blood and omental fat during the dosing period and the following year.Maximum concentrations determined in fat were in the order DDE > DDD > DDT in the approximate ratios 10: 2: 1. Rates of elimination from fat when dosing was stopped were in the order DDD >DDT >DDE, the half-life being 4, 9, and 14 weeks respectively. In fat, DDE appeared as a metabolite of DDD and DDT, and DDD as a metalobite of DDT. In the first trial the simultaneous administration of DDD and DDT with DDE appeared to stimulate the subsequent elimination of DDE from storage in fat, but this effect was not reproduced in the second trial. There was a correlation between DDE in fat (mg/kg = x) and DDE in whole blood (/Lg/kg = y) expressed by the regression equation.x = 1.8y-l.l A sheep was given one oral dose of DDE, DDD, and DDT simultaneously, each at the rate of 50 mg/kg body weight. Highest concentrations of DDT and DDE occurred in blood 15 hours and 32 hours respectively after dosing. DDD showed two maxima, at 8 hours and at 32 hours after dosing.The value of blood and fat analyses for diagnostic purposes is discussed in relation to the results of these trials.

show abstract

Distribution of p,p'-DDT residues in adipose and muscle tissues of beef cattle

Cited by 24 publications

References 7 publications

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

A Further Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity in Rats Receiving a 28-Day Repeated Administration of DDT

Metabolism of DDE, DDD, and DDT in sheep

Contact Info

Product

Resources

About