Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas

Sahin, Zeliha; Acar, Nuray; Ozbey, Ozlem; Üstünel, İ̇smail; Demir, Ramazan

doi:10.1016/j.acthis.2009.10.006

Cited by 34 publications

(38 citation statements)

References 28 publications

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“…Immunolocalization of proteins suggests that there is down-regulation of many Notch family proteins in preeclamptic placentas, including Notch1 , Sahin et al 2011, Notch2 (Sahin et al 2011) and Notch4 , Sahin et al 2011, Jagged1 ) and Jagged2 (Sahin et al 2011). Interestingly, this down-regulation is associated with R82 C Cuman, E Menkhorst and others a shift in protein localization from membrane-bound protein to cytoplasmic in Notch1, 2, 4 and Jagged1 (Sahin et al 2011), possibly indicating a shift from canonical to ligand-independent Notch signalling.…”

Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 96%

“…Interestingly, this down-regulation is associated with R82 C Cuman, E Menkhorst and others a shift in protein localization from membrane-bound protein to cytoplasmic in Notch1, 2, 4 and Jagged1 (Sahin et al 2011), possibly indicating a shift from canonical to ligand-independent Notch signalling. Notch expression in the placenta from IUGR is very similar to PE; immunostaining of Notch1, 2 and 4 and Jagged2 is reduced in the syncytiotrophoblast and the cellular localization of these receptors and ligand changes from being membrane-bound to cytoplasmic (Sahin et al 2011).…”

Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 99%

“…DLL1 (Herr et al 2011) and Jagged1 and 2 (Sahin et al 2011) are expressed by syncytiotrophoblast and DLL1 also by cytotrophoblast (Herr et al 2011). In non-trophoblast lineages, Notch1, Jagged1, DLL1 and DLL4 are expressed by endothelial cells (Herr et al 2011, Sahin et al 2011, while Hofbauer cells express Notch2, 3 and 4 (Herr et al 2011) and Notch3 and Jagged2 localize to the villous stroma (Herr et al 2011; Table 3). …”

Section: Placentamentioning

confidence: 99%

“…Notch1 is expressed by trophoblasts, certainly syncytiotrophoblasts ( (Herr et al 2011) and Notch4 (Sahin et al 2011) are also localized to the syncytiotrophoblasts and Notch3 localizes to the cytotrophoblasts (Herr et al 2011). DLL1 (Herr et al 2011) and Jagged1 and 2 (Sahin et al 2011) are expressed by syncytiotrophoblast and DLL1 also by cytotrophoblast (Herr et al 2011).…”

Section: Placentamentioning

confidence: 99%

“…Many studies have identified dysregulated expression of Notch family members in pre-eclamptic placentas , Sitras et al 2009, Hunkapiller et al 2011, Sahin et al 2011, Meng et al 2012, Taki et al 2012). Unfortunately, in many studies, the gestational age of the samples is not matched between pre-eclamptic and control (Sitras et al 2009, Meng et al 2012.…”

Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 99%

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Fetal–maternal communication: the role of Notch signalling in embryo implantation

Cuman¹,

Menkhorst²,

Winship³

et al. 2014

Reproduction

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The establishment of a successful pregnancy requires the implantation of a competent blastocyst into a 'receptive' endometrium, facilitating the formation of a functional placenta. Inadequate or inappropriate implantation and placentation is a major reason for infertility and is thought to lead to first-trimester miscarriage, placental insufficiency and other obstetric complications. Blastocystendometrial interactions are critical for implantation and placental formation. The Notch signalling family is a receptor-ligand family that regulates cellular processes as diverse as proliferation, apoptosis, differentiation, invasion and adhesion. Notch signalling is achieved via cell-cell interaction; thus, via Notch, cells can have direct effects on the fate of their neighbours. Recently, a number of studies have identified Notch receptors and ligands in the endometrium, blastocyst and placenta. This review collates current knowledge of this large receptor-ligand family and explores the role of Notch signalling during implantation and placentation, drawing on information from both human and animal studies. Overall, the evidence suggests that Notch signalling is a critical component of fetal-maternal communication during implantation and placentation and that abnormal Notch expression is associated with impaired placentation and pre-eclampsia.Reproduction (2014) 147 R75-R86

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Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 96%

Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 99%

Section: Placentamentioning

confidence: 99%

Section: Placentamentioning

confidence: 99%

Section: Clinical Implications Of Inadequate Implantation/placentationmentioning

confidence: 99%

See 3 more Smart Citations

Fetal–maternal communication: the role of Notch signalling in embryo implantation

Cuman¹,

Menkhorst²,

Winship³

et al. 2014

Reproduction

View full text Add to dashboard Cite

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Thrombosis during pregnancy: Risks, prevention, and treatment for mother and fetus—harvesting the power of omic technology, biomarkers and in vitro or in vivo models to facilitate the treatment of thrombosis

Ornaghi

Mueller

Barnea

et al. 2015

Birth Defects Research Pt C

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Maternal thromboembolism and a spectrum of placenta-mediated complications including the pre-eclampsia syndromes, fetal growth restriction, fetal loss, and abruption manifest a shared etiopathogenesis and predisposing risk factors. Furthermore, these maternal and fetal complications are often linked to subsequent maternal health consequences that comprise the metabolic syndrome, namely, thromboembolism, chronic hypertension, and type II diabetes. Traditionally, several lines of evidence have linked vasoconstriction, excessive thrombosis and inflammation, and impaired trophoblast invasion at the uteroplacental interface as hallmark features of the placental complications. "Omic" technologies and biomarker development have been largely based upon advances in vascular biology, improved understanding of the molecular basis and biochemical pathways responsible for the clinically relevant diseases, and increasingly robust large cohort and/or registry based studies. Advances in understanding of innate and adaptive immunity appear to play an important role in several pregnancy complications. Strategies aimed at improving prediction of these pregnancy complications are often incorporating hemodynamic blood flow data using non-invasive imaging technologies of the utero-placental and maternal circulations early in pregnancy. Some evidence suggests that a multiple marker approach will yield the best performing prediction tools, which may then in turn offer the possibility of early intervention to prevent or ameliorate these pregnancy complications. Prediction of maternal cardiovascular and non-cardiovascular consequences following pregnancy represents an important area of future research, which may have significant public health consequences not only for cardiovascular disease, but also for a variety of other disorders, such as autoimmune and neurodegenerative diseases.

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Differentially expressed circular RNAs in maternal and neonatal umbilical cord plasma from SGA compared with AGA

Wang

Dang

et al. 2019

J of Cellular Biochemistry

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Small for gestational age (SGA) has a high risk of mortality and morbidity and is common in obstetrics. To date, no effective prediction and treatment tools are available. Acting as microRNA (miRNA) sponges and disease biomarkers are clear functions of circular RNAs (circRNAs). However, it is still unknown what role circRNAs act in SGA. To explore the role of circRNAs in SGA, circRNA expression patterns of the umbilical cord and maternal plasma in SGA was assessed. We first evaluated circRNAs in umbilical cord blood of the SGA and appropriate for gestational age (AGA) groups by microarray sequencing. In total, 170 340 circRNAs were sequenced, and 144 circRNAs were significantly upregulated while 977 were markedly downregulated. Has_circRNA15994‐13, has_circ_0001359, and has_circ_0001360 were abundant and differentially expressed between the SGA and AGA groups, and confirmed in the umbilical cord and maternal blood specimens by reverse transcription polymerase chain reaction. By combining miRNA microarray data of the SGA placenta tissue in NCBI, it was found that two miRNAs were both hsa_circRNA15994‐13 targets and differentially expressed, including hsa‐miR‐3619‐5p and hsa‐miR‐4741. Further KEEG analysis revealed that the most significant pathway enriched by hsa‐miR‐3619‐5p was Wnt signaling that is closely related to SGA; meanwhile, previous reports demonstrated that hsa‐miR‐3619‐5p directly binds to β‐catenin to accommodate the Wnt/β‐catenin pathway, whereby the suggestive hsa_circRNA15994‐13 → hsa‐miR‐3619‐5p → β‐catenin signaling pathway may play an important part in SGA.

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Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas

Cited by 34 publications

References 28 publications

Fetal–maternal communication: the role of Notch signalling in embryo implantation

Fetal–maternal communication: the role of Notch signalling in embryo implantation

Thrombosis during pregnancy: Risks, prevention, and treatment for mother and fetus—harvesting the power of omic technology, biomarkers and in vitro or in vivo models to facilitate the treatment of thrombosis

Differentially expressed circular RNAs in maternal and neonatal umbilical cord plasma from SGA compared with AGA

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