Fetal–maternal communication: the role of Notch signalling in embryo implantation

Cuman, Carly; Menkhorst, Ellen; Winship, Amy; Sinderen, Michelle Leigh Van; Osianlis, Tiki; Rombauts, Luk; Dimitriadis, Evdokia

doi:10.1530/rep-13-0474

Cited by 67 publications

(63 citation statements)

References 77 publications

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“…It is reported that EMT is induced by NOTCH signaling, an intracellular signaling pathway induced by cell attachment (Gonzalez & Medici 2014). On blastocyst implantation, NOTCH signaling is achieved via cell-cell interaction, in which NOTCH receptors expressed on the surface of endometrium interact with ligands present on the surface of blastocysts in humans and mice (Cuman et al 2014). Activin A or TGF-β upregulates several transcription factors such as SNAI2, ZEB1 or TWIST1 mediated by phosphorylated SMAD2 or SMAD3 (Lamouille et al 2014, Li et al 2015.…”

Section: Regulation Of Emt-related Molecule Expression During the Permentioning

confidence: 99%

Continuous model of conceptus implantation to the maternal endometrium

Imakawa

Bai

Fujiwara

et al. 2017

Journal of Endocrinology

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As placental morphology as well as trophoblast characteristics exhibit wide diversity across mammalian species, underling molecules were also thought to vary greatly. In the majority of cases, however, regardless of the mode of implantation, physiological and biochemical processes in conceptus implantation to the maternal endometrium including the kinds of gene expression and their products are now considered to share many similarities. In fact, recent progress has identified that in addition to the hormones, cytokines, proteases and cell adhesion molecules classically characterized, molecules related to lymphocyte homing and epithelial-mesenchymal transition (EMT) are all required for the progression of conceptus implantation to placentation. In this review, therefore, the newest findings are all incorporated into the molecular and cellular events related to conceptus implantation to the maternal endometrium; primarily from non-invasive bovine placentation and also from invasive human implantation.

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Section: Regulation Of Emt-related Molecule Expression During the Permentioning

confidence: 99%

Continuous model of conceptus implantation to the maternal endometrium

Imakawa

Bai

Fujiwara

et al. 2017

Journal of Endocrinology

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“…Notch signaling is critical for maternal-fetal communication during implantation and placentation (9). Our laboratory has previously reported that both the conditional deletion of Notch1 in the mouse uterus and NOTCH1 silencing in Human Uterine Fibroblasts (HuFs) inhibit decidualization (10,11).…”

mentioning

confidence: 99%

Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility

Strug

Jeong

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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In mammalian reproduction, implantation is one of the most critical events. Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy losses in women. Our laboratory has previously reported that inhibition of Notch signaling results in impaired decidualization in both women and a transgenic mouse model. In this study, we generated a Notch gain-of-function transgenic mouse by conditionally overexpressing the Notch1 intracellular domain (N1ICD) in the reproductive tract driven by a progesterone receptor (Pgr) -Cre. We show that the overexpression of N1ICD in the uterus results in complete infertility as a consequence of multiple developmental and physiological defects, including the absence of uterine glands and dysregulation of progesterone and estrogen signaling by a Recombination Signal Binding Protein Jκ-dependent signaling mechanism. We further show that the inhibition of progesterone signaling is caused by hypermethylation of its receptor Pgr by Notch1 overexpression through the transcription factor PU.1 and DNA methyltransferase 3b (Dnmt3b). We have generated a mouse model to study the consequence of increased Notch signaling in female reproduction and provide the first evidence, to our knowledge, that Notch signaling can regulate epigenetic modification of the Pgr. mouse uterus | Notch1 | Pgr | methylation | infertility

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“…Notch1-3 are additionally expressed by the trophectoderm of human blastocysts (Aghajanova et al, 2012). Notch ligands and receptors are localized to the apical surface of the luminal epithelium during the midsecretory phase of the menstrual cycle, where they are accessible to ligands and receptors on the trophectoderm, in order to facilitate endometrial-embryo attachment (Cuman et al, 2014).…”

Section: Notch Signalingmentioning

confidence: 99%

Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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Successful pregnancy is dependent upon the implantation of a competent embryo into a receptive endometrium. Despite major advancement in our understanding of reproductive medicine over the last few decades, implantation failure still occurs in both normal pregnancies and those created artificially by assisted reproductive technology (ART). Consequently, there is significant interest in elucidating the etiology of implantation failure. The complex multistep process of implantation begins when the developing embryo first makes contact with the plasma membrane of epithelial cells within the uterine environment. However, although this biological interaction marks the beginning of a fundamental developmental process, our knowledge of the intricate physiological and molecular processes involved remains sparse. In this synopsis, we aim to provide an overview of our current understanding of the morphological changes which occur to the plasma membrane of the uterine endothelium, and the molecular mechanisms that control communication between the early embryo and the endometrium during implantation. A multitude of molecular factors have been implicated in this complex process, including endometrial integrins, extracellular matrix molecules, adhesion molecules, growth factors, and ion channels. We also explore the development of in vitro models for embryo implantation to help researchers investigate mechanisms which may underlie implantation failure. Understanding the precise molecular pathways associated with implantation failure could help us to generate new prognostic/diagnostic biomarkers, and may identify novel therapeutic targets.

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Fetal–maternal communication: the role of Notch signalling in embryo implantation

Cited by 67 publications

References 77 publications

Continuous model of conceptus implantation to the maternal endometrium

Continuous model of conceptus implantation to the maternal endometrium

Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility

Molecular mechanisms of membrane interaction at implantation

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