Distribution of neuropeptides in endocrine and exocrine pancreas of long-legged buzzard (Buteo rufinus): An immunohistochemical study

Bayrakdar, Ali; Yaman, Mine; Atalar, Ömer; Tarakçi, Berrin Gençer; Çeribaşı, Songül

doi:10.1016/j.regpep.2010.10.007

Cited by 12 publications

(15 citation statements)

References 46 publications

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“…According to Tarakci et al [8] , the alpha cells of ostrich are located in the periphery of the islets. Our findings revealed predominantly in the throughout of the alpha islets in the sparrowhawk pancreas, which is in accordance with previous studies [2,5,6,14] . Also, this study, single or 2-3 alpha cell clusters were observed in the pancreatic parenchyma.…”

Section: Glucagonsupporting

confidence: 94%

“…Endocrine islets show different distributions, locations, and characteristics among avian species [1] . A high number of alpha-, beta-, and somatostatin-releasing cells, and a small number of gastrin-, serotonin-, substance P-, neuropeptide Y-, and cholecystokinin-8-releasing cells are located in the pancreatic endocrine islets of some avian species [3,5,6,[12][13][14]16] . Therefore, the present study aimed to investigate the distribution and location of endocrine cells in the pancreas of the sparrowhawk.…”

Section: Discussionmentioning

confidence: 99%

“…The Endocrine region of the pancreas in avian species generally consists of large-diameter alpha islets, a higher number of beta islets [6,17] , and a few or no mixed islets [5,14] . In many studies, the number of endocrine islets in both avian and mammalian species is higher in the splenic lobe (tail region) than the other lobes of the pancreas [14,18] .…”

Section: Discussionmentioning

confidence: 99%

“…Avian islets of Langerhans are divided into alpha, beta, and mixed islets according to their cellular composition [6,7] . Each islet of Langerhans in mammalian pancreas consists of a few to several thousand cells [9,10] , which are alpha (A, A2, α), beta (B, β), delta (D, δ), and pancreatic polypeptides (PP, F).…”

Section: Introductionmentioning

confidence: 99%

“…Each islet of Langerhans in mammalian pancreas consists of a few to several thousand cells [9,10] , which are alpha (A, A2, α), beta (B, β), delta (D, δ), and pancreatic polypeptides (PP, F). Some authors have reported that the islets of Langerhans may also contain substance P, neuropeptide Y, serotonin, cholecystokinin-8, galanin [6] , gastrin, and ghrelin-immunopositive cells in the some avian species [1] . In the mammalians, beta cells are located generally in the central of islets, and alpha cells located in the periphery of islets in humans, rats, and mice [1] , however these cells are opposite position in the pancreatic islets of horses [2] , monkey and kangaroo [11] .…”

Section: Introductionmentioning

confidence: 99%

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Distribution and Location of Endocrine Cells in the Pancreas of the Sparrowhawk, Accipiter nisus

Kara¹,

Tekiner²,

Şimşek³

et al. 2014

Kafkas Univ Vet Fak Derg

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The distribution and location of endocrine cells were determined in the dorsal, ventral, and splenic lobes of sparrowhawk pancreas using immunohistochemical methods. In this study, pancreatic tissues were stained with anti-insulin, anti-glucagon, anti-somatostatin, anti-gastrin, and anti-serotonin primary antibodies using the streptavidin-biotin-peroxidase method. The results showed that the numbers of glucagon-(alpha cell), insulin-(beta cell), and somatostatin-(delta cell) releasing cells were high and located in the splenic lobe of the pancreas. These endocrine cells were grouped into alpha, beta, and mixed islets. Alpha islets were mainly composed of alpha and delta cells and also occasionally beta cells. Beta islets contained numerous beta cells and a few delta and alpha cells. Furthermore, in the exocrine tissue were showed as only one cell or 2-3 gastrin immunopositive cell groups, whereas serotonin immunopositive cells were not found anywhere in the exocrine and endocrine pancreas. In conclusion, the endocrine islet types, endocrine cell localizations and lobe numbers of pancreas in sparrowhawks are similar to predator bird species, but are determined different to domestic fowls. Keywords: Insulin, Glucagon, Somatostatin, Gastrin, Pancreas, Sparrowhawk Atmaca (Accipiter nisus) Pankreas Dokusu Endokrin Hücrelerin Dağılımı ve Lokalizasyonu ÖzetBu çalışmada, atmaca pankreasının dorsal, ventral ve splenik loblarında bulunan endokrin hücrelerin dağılımı immunhistokimysal metotlarla belirlenmiştir. Pankreas dokusu anti-glukagon, anti-insulin, anti-gastrin ve anti-somatostatin primer antikorları kullanılarak streptavidin-biotin peroxidase metodu ile boyandı. Çalışmada, glukagon (alfa hücresi), insülin (beta hücresi) ve somatostatin (delta hücresi) salgılayan hücrelerin splenik lobda sayısının en fazla olduğu saptandı. Atmalarda pankreasın endokrin bölümlerinin alfa, beta ve miks adacıklar halinde gruplaştıkları saptandı. Beta adacıklarının çok sayıda beta hücresi, az sayıda delta ve alfa hücrelerini içerdiği belirlendi. Alfa adacıkları, genellikle alfa ve delta hücrelerinden nadiren de beta hücrelerinden oluşuyordu. Ayrıca, gastrin pozitif hücreler, sadece ekzokrin pankreasta 1 ya da 2-3 adet hücre grubu halinde bulunurken, seratonin pozitif hücrelere ise ekzokrin ve endokrin pankreasın herhangi bir bölümünde rastlanmadı. Sonuç olarak, atmaca pankreasının lop sayısı, endokrin adacık tipleri ve endokrin hücre lokalizasyonu açısından etçil kuşlarla benzerliği, evcil kuş türleriyle de farklılıkları belirlenmiştir.

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Section: Glucagonsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Distribution and Location of Endocrine Cells in the Pancreas of the Sparrowhawk, Accipiter nisus

Kara¹,

Tekiner²,

Şimşek³

et al. 2014

Kafkas Univ Vet Fak Derg

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Histology and immunofluorescent study of the pancreas in lovebird (Agapornis personatus)

Goodarzi,

Bashiri

2024

Veterinary Medicine & Sci

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BackgroundLovebird (Agapornis personatus) is a monotypic species of bird of the lovebird genus in the parrot family Psittaculidae and order Psittaciformes.ObjectivesThe present study was designed to investigate the histology and immunohistochemistry of the pancreas in the lovebird.MethodsTotally, three adult birds were used. The pancreas was assessed using histological and immunofluorescent staining to detect insulin, glucagon, somatostatin, pancreatic polypeptide (PP) and neuropeptide Y (NY).ResultsThe exocrine pancreas was composed of pyramidal acinar cells with zymogen granules at the apical cytoplasm. The endocrine pancreas was identified as large alpha, small beta and mixed islets of Langerhans. No intercalated duct was observed. Alpha cells with a density of 28.55% were the most numerous cell type, which were populated throughout the large islets, especially at the periphery. The beta cells with a density of 15.78% were accumulated mostly at the periphery of islets. The delta cells exhibited 17.81% intensity. Despite their lower density, the distribution of delta cells was like that of A cells throughout the islets. PP and NY cells were distinguished with densities of 14.69% and 20.63%, respectively.ConclusionsAlthough the arrangement of acinar cells, ductal systems and endocrine islets reflects patterns observed in various avian species, the absence of intercalated duct, the presence of three types of Langerhans islets as alpha, beta and mixed islets and the high expression of NY in the islets were some unique features observed in the current study. These findings contribute to the broader understanding of avian pancreas histology.

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Endocrine System

Ritchison

2023

Fascinating Life Sciences

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Distribution of neuropeptides in endocrine and exocrine pancreas of long-legged buzzard (Buteo rufinus): An immunohistochemical study

Cited by 12 publications

References 46 publications

Distribution and Location of Endocrine Cells in the Pancreas of the Sparrowhawk, Accipiter nisus

Distribution and Location of Endocrine Cells in the Pancreas of the Sparrowhawk, Accipiter nisus

Histology and immunofluorescent study of the pancreas in lovebird (Agapornis personatus)

Endocrine System

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