Distribution of <i>CTLA-4 </i>Polymorphisms in Allergic Asthma

Abstract

Background: The CTLA-4 molecule is an important negative regulator of T cell activation. It is encoded on chromosome 2q33 and found to be associated with several allergic phenotypes including asthma. However, the association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study. Methods: By PCR-RFLP, the distribution of three single nucleotide polymorphisms (SNPs), –1147 C/T, –318 C/T, and +49 A/G, was examined in 219 Polish Caucasoid patients diagnosed with allergic asthma and in 102 ethnically matched healthy control individuals. (AT)_n microsatellite polymorphism was also tested in the same individuals. Results:No statistically significant differences in SNPs or microsatellite allele, genotype or haplotype frequencies between patients and controls were found. Conclusion:CTLA-4 polymorphisms do not seem to be a risk factor for allergic asthma in Poles.

Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma

“…13 The patients were subdivided according to NHLBI/WHO guidelines into three subgroups: asthma I, mild asthma (54 individuals); asthma II, moderate asthma (52 individuals); and asthma III, severe asthma (92 individuals). Characteristics of the patients are shown in Table 1b.…”

Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis

“…There were 11 studies on +49 A/G, 12 studies on −318 C/T, 6 studies on −1147 C/T, 5 studies on CT60 A/G, 3 studies on −1722 C/T and rs926169. There were 10 studies of Asians [15], [17], [25]–[27], [29], [32], [34], [37], [38] and 6 studies of Caucasians [16], [28], [30], [31], [33], [36]. Five studies were performed in adults [15]–[17], [34], [38], 11 studies in children [25]–[27], [29]–[32], [34]–[37].…”

“…Five studies were performed in adults [15]–[17], [34], [38], 11 studies in children [25]–[27], [29]–[32], [34]–[37]. Two studies included both adults and juveniles [28], [33]. Five studies included only atopic asthma patients [27], [28], [34], [35], [38].…”

“…Two studies included both adults and juveniles [28], [33]. Five studies included only atopic asthma patients [27], [28], [34], [35], [38]. Four studies included both atopic and non-atopic asthma patients but the data for these patients could be separately extracted 17,25,26,30.…”

Cytotoxic T lymphocyte‐associated antigen‐4 gene polymorphisms confer susceptibility to atopic asthma in Korean children

“…11,12 However, other authors have found no associations with asthma or atopy. [13][14][15] We investigated whether polymorphisms in the CTLA-4 promoter (À318) and exon 1 (þ49) are associated with susceptibility to asthma and its clinical features in Korean children.…”