Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis

Abstract

BackgroundA number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility.MethodsPubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.ResultsSeventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01–1.37, P = 0.04). There were no significant associations between −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, or rs926169 polymorphisms and asthma risk.ConclusionsThis meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.

Association between Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Sepsis: A Meta-Analysis

“…ORs were calculated for the genotypes: 4G/4G vs. 5G/5G (OR1), 4G/5G vs. 5G/5G (OR2), and 4G/4G vs. 4G/5G (OR3) for the -675 4G/5G polymorphism. These pairwise differences were used to indicate the most appropriate genetic model as follows: if OR1 =  OR3 ≠ 1 and OR2 = 1, then a recessive model was suggested; if OR1 =  OR2 ≠ 1 and OR3 = 1, then a dominant model was suggested; if OR2 = 1/OR3 ≠ 1 and OR1 = 1, then a complete overdominant model was suggested; if OR1> OR2>1 and OR1> OR3>1 (or OR1< OR2<1 and OR1< OR3<1), then a codominant model was suggested [23]–[25]. Once the best genetic model was identified, this model was used to collapse the three genotypes into two groups (except in the case of a codominant model) and to pool the results again.…”

Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

“…OR1, OR2, and OR3 regarding IL-13 +1923C/T polymorphism were calculated for genotypes TT versus CC, TC versus CC, and TT versus TC, respectively. These pairwise differences were used to indicate the most appropriate genetic model as follows: if OR1 = OR3 ≠ 1 and OR2 = 1, then a recessive model was suggested; if OR1 = OR2 ≠ 1 and OR3 = 1, then a dominant model was suggested; if OR2 = 1/OR3 ≠ 1 and OR1 = 1, then a complete overdominant model was suggested; if OR1 > OR2 > 1 and OR1 > OR3 > 1 (or OR1 < OR2 < 1 and OR1 < OR3 < 1), then a codominant model was suggested [16–18]. Once the best genetic model was identified, this model was used to collapse the three genotypes into two groups (except in the case of a codominant model) and to pool the results again.…”

Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

“…These pairwise differences were used to indicate the most appropriate genetic model as following: if OR1 = OR3 ≠ 1 and OR2 = 1, then a recessive model was suggested; if OR1 = OR2 ≠ 1 and OR3 = 1, then a dominant model was suggested; if OR2 = 1/OR3 ≠ 1 and OR1 = 1, then a complete overdominant model was suggested; if OR1 > OR2 > 1 and OR1 > OR3 > 1 (or OR1 < OR2 < 1 and OR1 < OR3 < 1), then a codominant model was suggested. [19][20][21][22][23] Once the best genetic model was identified, this model was used to collapse the three genotypes into two groups (except in the case of a codominant model) and to pool the results again. The significance of the pooled OR was determined by the z-test, and two-tailed p < 0.05 was considered as statistically significant.…”