Distribution of Lipofuscin in the Canine and Porcine Brain As Related to Aging

Whiteford, Robert Daniel; Getty, R.

doi:10.1093/geronj/21.1.31

Cited by 63 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Harms (1924) found heavy accumulations of pigment in the pyramidal cells of the cerebrum. Sulkin In recent studies of the dog and hog brain (Whiteford, 1964, andGetty, 1966), it was found that lipofuscin was absent in the neurons of animals under one year of age and that it was universally present in old animals. As a result of these studies, the authors concluded that lipofuscin pigment increased with age throughout the life span of the animal and that pigment was the only con sistent cellular alteration that could be correlated with age in the specimens studied.…”

Section: Occurrence and Distribution Of Llpofuscln In The Nervous Systemmentioning

confidence: 99%

“…According to Altschul (1943) These physiologic alterations could result in the loss of cells (Samorajski et al, 1965). Whiteford (1964), on studies of dog and hog brains, interpreted the increased amount of lipofuscin with age and the concomitant alterations in pigment distribution as simply evidence of cellular aging. He further explained, however, that from a purely anatomical point of view, the size and density of lipofuscin accumulations in the neurons of older specimens would be likely to reflect or cause some impaired function.…”

Section: Functional Significance Of Lipofuscin In the Nerve Cellmentioning

confidence: 99%

“…According to Sulkin (1955a), lipofuscin in old dogs gives a positive Schiff reaction after prior oxidation with periodic, performic, and peracetlc acids, and the periodic acid reaction (Heidenreich and Siebert, 1955j Lillie 1956a, 1956bWhiteford, 1964;and Nandy, I966). According to Lillie (1956b), lipofuscins stain with Nile blue by two mechanismsa fat-solubility one which operates at pH levels below 1.0, and an acid-base mechanism operating at pH levels above 3.0.…”

Section: Histochemistrymentioning

confidence: 99%

“…The results were that lipofuscins colored deep blue, melanins dark green, myelin and red cells lighter green, and the background pale green. Whiteford (1964) used the Nile blue stain to demonstrate lipofuscin in the brains of dogs and hogs. Other lipid stains such as Sudan black B, Sudan III, IV, V, scarlet red, and neutral red have been used to stain lipofuscin (Sulkin, 1955a;Heidenreich and Siebert, 1955;Issidorides and Shanklin, 196I;Samorajski et al, 1964Samorajski et al, , 1966and Nandy, 1966).…”

Section: Histochemistrymentioning

confidence: 99%

“…There are a few reports of studies on the dog (Dolley, 1911;Goodpasture, 1918;Harms, 1924; Sulkin and Kuntz, 1952; Sulkin, 1953Sulkin, , 1955aSulkin, , 1955b; Whiteford, 1964;and Whiteford and Getty, 1966). There are only two reports of age studies on the nervous system of the pig, both dealing with age changes in various brain stem nuclei (Whiteford, 1964, andGetty, 1966).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

Few

View full text Add to dashboard Cite

Section: Occurrence and Distribution Of Llpofuscln In The Nervous Systemmentioning

confidence: 99%

Section: Functional Significance Of Lipofuscin In the Nerve Cellmentioning

confidence: 99%

Section: Histochemistrymentioning

confidence: 99%

Section: Histochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

Few

View full text Add to dashboard Cite

Topographical localization of lipofuscin pigment in the brain of the aged fat-tailed dwarf lemur(Cheirogaleus Medius) and grey lesser mouse lemur(Microcebus Murinus): Comparison to iron localization

et al. 1999

View full text Add to dashboard Cite

The present study was undertaken to explore the distribution of lipofuscin in the brain of cheirogaleids by autofluorescence and compare it to other studies of iron distribution. Aged dwarf (Cheirogaleus medius) and mouse (Microcebus murinus) lemurs provide a reliable model for the study of normal and pathological cerebral aging. Accumulation of lipofuscin, an age pigment derived by lipid peroxidation, constitutes the most reliable cytological change correlated with neuronal aging. Brain sections of four aged (8–15 year old) and 3 young (2–3 year old) animals were examined. Lipofuscin accumulation was observed in the aged animals but not in the young ones. Affected regions include the hippocampus (granular and pyramidal cells), where no iron accumulation was observed, the olfactory nucleus and the olfactory bulb (mitral cells), the basal forebrain, the hypothalamus, the cerebellum (Purkinje cells), the neocortex (essentially in the pyramidal cells), and the brainstem. Even though iron is known to catalyse lipid oxidation, our data indicate that iron deposits and lipofuscin accumulation are not coincident. Different biochemical and morphological cellular compartments might be involved in iron and lipofuscin deposition. The nonuniform distribution of lipofuscin indicates that brain structures are not equally sensitive to the factors causing lipofuscin accumulation. The small size, the rapid maturity, and the relatively short life expectancy of the cheirogaleids make them a good model system in which to investigate the mechanisms of lipofuscinogenesis in primates. Am. J. Primatol. 49:183–193, 1999. © 1999 Wiley‐Liss, Inc.

show abstract

Lipofuscin pigment in neurons of young mice with a hereditary central nervous system defect

O'Steen¹,

Nandy²

1970

Am. J. Anat.

View full text Add to dashboard Cite

Mutant mice are described which have a n early developing locomotor difficulty accompanied by definite neuronal changes in the central nervous system. They develop head tremors during the second postnatal week and later action tremors while walking. Seizures occur spontaneously and ran be induced by stimulation. By the third or fourth week, they lose the righting reflex. The most apparent neuropathologic sign is the progressive development o f nuclear hyperchromasia, especially in the largest neurons of the spinal cord and brain stem. Purkinje cells of the cerebellum are similarly affected. Hyperchromasia occurs in single, isolated neurons scattered throughout the central nervous system, as well as in groups of cells which comprise a brain stem nucelus. Lipofuscin pigment in quantities comparable to that i n neurons of 12 months old mice was found i n neurons with hyperchromatic nuclei as early as five weeks of age, a n observation which suggests that premature aging might be occurring in the mutant's central nervous system.A large number of inherited motor defects have been described in mice, and many of these can be attributed to specific mutations (Fuller and Wimer, '66). Such mutations, which during early development lead to degeneration of the myeliE sheaths, defective cerebellar development, and degeneration of dorsal root ganglia, cause neurological syndromes, such as convulsions and uncoordinated behavior (Fuller and Wimer, '66).Neuropathologic changes apparently do not exist in some mutants and have not been described in others, and the cause of the behavioral abnormalities either has not been determined or is related to biochemical defects of metabolism not associated with tissue changes in the nervous system.In the mutant group of mice in this study, definite neuronal abnormalities develop throughout the central ncrvous system as the behavioral syndrome grows progressively more severe. Neurons of these affected mice have been compared with those of normal littermates for the presence of' lipofuscin pigment, in an attempt to determine the occurrence of premature aging in the central nervous system of mutant mice. MATERIALS AND METHODS Mice 359

show abstract

Distribution of Lipofuscin in the Canine and Porcine Brain As Related to Aging

Cited by 63 publications

References 0 publications

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

Topographical localization of lipofuscin pigment in the brain of the aged fat-tailed dwarf lemur(Cheirogaleus Medius) and grey lesser mouse lemur(Microcebus Murinus): Comparison to iron localization

Lipofuscin pigment in neurons of young mice with a hereditary central nervous system defect

Contact Info

Product

Resources

About