Distribution of killer cell immunoglobulin‐like receptors genotypes in the Lebanese population

Abstract

This study represents the first report on the distribution of 16 Killer cell Immunoglobulin-like Receptors (KIR) genes in 120 unrelated healthy Lebanese individuals. We observed that 2DL2 frequency (61%) comes second highest after South Asians (64%) and 2DL5 frequency (58.3%) is the second highest reported so far after the South Asians (74%). Interestingly, a large number of AA1 genotype individuals with no loci for activating KIR and three completely new BB profiles not previously reported were found in our population with a group A : group B haplotypes ratio of 1.3:1. The frequency of the KIR loci suggests that the Lebanese population shares common general features with the Caucasoid populations studied before, but still has its own unique decreased or increased frequencies of several loci.

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná

“…The genotype classified as 34 was characterized by the lack of KIR2DL2, KIR2DL3, and KIR2DS5. The absence of KIR2DL2 and KIR2DL3 has been reported previously [29,30,37], although some studies indicated that KIR2DL2/3 are alleles of the same locus [8,15,44] and that KIRs for HLA-C1 are found in all individuals [22,44]. The genotype classified as 37 lacks KIR2DP1 and KIR2DS3.…”

Distribution of killer cell immunoglobulinlike receptors in the Macedonian population

“…We report here genetic distances of 14 KIR genes for 33 populations, deposited in the Allele Frequencies database (http://allelefrequencies.net) [23] or published [50,[52][53][54][55][56][57], and they group in several clusters. Populations from Oman, Lebanon, Belgium, Spain Guadeloupe, Senegal, and South Africa Xhosa are in the same cluster on the bottom of the tree.…”

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China

“…A hierarchical cluster was conducted based on allelic frequencies of the same 14 KIRs of our observed population and other previously published populations [26,31,32,35,36,38,39,44,[50][51][52], and a neighborjoining tree was constructed using SPSS 13.0 software. The result is shown in Figure 1.…”