Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná

Rudnick, Cristiane Conceição Chagas; Franceschi, Danilo Santana Alessio; Marangon, Amanda Vansan; Guelsin, Gláucia Andréia Soares; Sell, Ana Maria; Visentainer, Jeane Eliete Laguila

doi:10.1016/j.humimm.2008.09.002

Cited by 27 publications

(26 citation statements)

References 44 publications

(62 reference statements)

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“…The frequencies of the KIR genes in our control group were similar to other studies reported for Brazilian populations [22,23]. The proportion of controls with inhibitory KIR2DL2 receptors was significantly higher than that of patients with SSc (crude OR: 0·22, 95% CI: 0·12-0·40, adjusted P < 0·0001; M-H OR, stratified for race and sex: 0·23, 95% CI: 0·13-0·41, adjusted P < 0·0001).…”

Section: Resultssupporting

confidence: 88%

Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis

Salim¹,

Jobim²,

Bredemeier

et al. 2010

Clinical and Experimental Immunology

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SummaryA previous study has suggested that the combination KIR2DS2 + /KIR2DL2was related to increased risk for systemic sclerosis (SSc), while others have failed to reproduce this finding. Our objective was to study this matter further and test the association of other KIR genes with SSc. One hundred and ten SSc patients and 115 healthy bone marrow donors were enrolled in a case-control study. Blood was collected for DNA extraction; typing of 15 KIR genes and human leucocyte antigen-C (HLA-C) was made by polymerase chain reaction with sequence specific primers (PCR-SSP), followed by electrophoresis on agarose gel. Patients underwent clinical evaluation, serology, Doppler echocardiography and chest high-resolution computed tomography. The frequency of the inhibitory KIR2DL2 was significantly lower in patients [29·1% versus 65·2% in controls, P < 0·0001; odds ratio (OR) = 0·22, 95% confidence interval 0·12-0·40]. When combinations of activating and inhibitory KIR genes were analysed, the presence of KIR2DS2 in the absence of KIR2DL2 (KIR2DS2 + /KIR2DL2 -) was more frequent in patients than in controls (25·5% versus 1·7%, respectively; P < 0·0001; OR = 19·29, 4·24-122·26). However, the presence of both KIR2DS2 and KIR2DL2 (KIR2DS2 + /KIR2DL2 + ) was more frequent in controls (57·4%) than in patients (28·2%, P < 0·0001), suggesting a preponderant protective effect of KIR2DL2 over KIR2DS2. Stratification for HLA-C1 status did not change these results. No statistically significant associations were found between KIR phenotypes and clinical and laboratory features of SSc. Our results suggest a protective role of KIR2DL2 + phenotype and confirmed the association of the combination KIR2DS2 + /KIR2DL2 -with increased risk for SSc.

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Section: Resultssupporting

confidence: 88%

Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis

Salim¹,

Jobim²,

Bredemeier

et al. 2010

Clinical and Experimental Immunology

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“…Their functions are regulated by a series of inhibitory or activating receptors [5]. There are three main families of NK cell receptors: the KIRs, the C-type lectin (CD94/NKGs), and the immunoglobulin-like transcripts [6]. KIRs are surface receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by NK cells and a subset of T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China

et al. 2010

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“…A total of 616 patients were excluded based on the following criteria: human immunodeficiency virus-positive serology, hepatitis B virus coinfection, other hepatic diseases, presence of non-1 HCV genotype, and history of antiviral therapy before liver biopsy. In addition, 289 unrelated healthy individuals from Southern Brazil [17] were used as controls and compared with HCV patients.…”

Section: Studied Populationmentioning

confidence: 99%

“…The samples with doubtful results were confirmed by in-house PCR with sequence specific primers according to Martin [21] and optimized by Rudnick et al [17].…”

Section: Kir2ds4mentioning

confidence: 99%