Distribution of Interleukin‐1β<sup>+3954</sup> and IL‐1α<sup>–889</sup> Genetic Variations in a Thai Population Group

Anusaksathien, Orasa; Sukboon, Angkana; Sitthiphong, Piyawan; Teanpaisan, Rawee

doi:10.1902/jop.2003.74.12.1796

Cited by 53 publications

(69 citation statements)

References 39 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, the IL-1α rs17561 polymorphism showed a strong association with periodontitis (Rogers et al, 2002;Wagner et al, 2007;López et al, 2009). However, several other authors have been unable to demonstrate any such relationship (Anusaksathien et al, 2003;Sakellari et al, 2003;Brett et al, 2005;Kobayashi et al, 2007;Ferreira Jr. et al, 2008).…”

Section: Discussionmentioning

confidence: 91%

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we performed a meta-analysis to explore the relationship between IL-1 polymorphism and periodontitis risk. Based on our inclusion criteria, six case-control studies were used, involving a total of 336 periodontitis cases and 366 healthy controls. Our meta-analysis results showed that the T allele of IL-1α rs17561 is positively associated with periodontitis susceptibility. In addition, carriers of this allele (TC + TT genotypes) demonstrated increased risk of this disease. The IL-1β rs1143634 T allele was also positively connected to periodontitis, with TC + TT genotype carriers being significantly more at risk. These results demonstrate that the IL-1α rs17561 and IL-1β rs1143634 polymorphisms are associated with periodontitis.

show abstract

Section: Discussionmentioning

confidence: 91%

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…According to Asian [6], Japanese [39] and Brazilian [40] studies, the carriage rate in these populations was found to be lower than that reported for the Caucasian [35,41]. The lower carriage has also been reported in the Arab population where in Syrian Arabs, the rate was 12.5% and 8.6% in chronic periodontitis and controls [42].…”

Section: Discussionmentioning

confidence: 82%

“…The prevalence of IL-1 composite genotype is low among Asian populations. The prevalence reported in Chinese subjects is 2.3%, [5] 2% in Thai subjects, [6] 0.2% in Japanese persons, [7] and 14% in Indians [8]. Other Indian studies reported no association of IL-1B (+3954) and chronic periodontitis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Wagaiyu¹,

Bulimo²,

Wanzala³

et al. 2014

IOSRJDMS

View full text Add to dashboard Cite

show abstract

“…Cullinan et al (2001), in a prospective study in Queensland reported IL-1 genotype-positive subjects demonstrated attachment loss and increased mean pocket depth in nonsmokers. SNPs in the IL-1 gene were found not to contribute to chronic periodontitis susceptibility in Greek (Sakellari et al, 2006), Jordanian (Karasneh et al, 2011), Chinese (Armitage et al, 2000), and Thai (Anusaksathien et al, 2003) populations. The wide variation in this association may be due to the ethnicity of the target population.…”

Section: Discussionmentioning

confidence: 83%

Polymorphic Regions in the Interleukin-1 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study

LavuVamsi

Venkatesan

Lakkakula

et al. 2015

Genetic Testing and Molecular Biomarkers

View full text Add to dashboard Cite

Objective: The objectives of this study were to determine the association between single nucleotide polymorphisms (SNPs) in IL1B ( -511, + 3954), IL1A ( -889, + 4845), and the variable number of tandem repeats (VNTRs) polymorphism in the IL-1RN gene with chronic periodontitis susceptibility and to analyze gene-gene interactions in a hospital-based sample population from South India. Subjects and Methods: A total of 400 individuals were recruited for this study; 200 individuals with healthy gingiva and 200 chronic periodontitis patients. Genomic DNA was isolated from peripheral blood samples and genotyping was performed for the above-mentioned single nucleotide and VNTR polymorphisms by polymerase chain reaction, DNA sequencing, and agarose gel electrophoresis. Results: A higher proportion of the variant alleles were observed in the chronic periodontitis group for all the SNPs examined. The SNP at + 3954 (C > T) in the IL1B gene was found to be significantly associated with chronic periodontitis ( p = 0.007). VNTR genotypes (v 2 value: 5.163, df = 1, p = 0.023) and alleles (v 2 value: 6.818, df = 1, p = 0.009) were found to have a significant association with chronic periodontitis susceptibility. Conclusion: In the study population examined, the SNP in the IL1B gene ( + 3954) and VNTR polymorphisms in the IL1RN gene were found to have a significant association with chronic periodontitis susceptibility.

show abstract

Distribution of Interleukin‐1β⁺³⁹⁵⁴ and IL‐1α^–889 Genetic Variations in a Thai Population Group

Abstract: Genetic polymorphism of IL-1 genes in these two loci may not be useful in predicting the severity of periodontal disease in the Thai ethnic group.

Cited by 53 publications

References 39 publications

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Polymorphic Regions in the Interleukin-1 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study

Contact Info

Product

Resources

About

Distribution of Interleukin‐1β+3954 and IL‐1α–889 Genetic Variations in a Thai Population Group

Abstract: Genetic polymorphism of IL-1 genes in these two loci may not be useful in predicting the severity of periodontal disease in the Thai ethnic group.

Cited by 53 publications

References 39 publications

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Polymorphic Regions in the Interleukin-1 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study

Contact Info

Product

Resources

About

Distribution of Interleukin‐1β⁺³⁹⁵⁴ and IL‐1α^–889 Genetic Variations in a Thai Population Group