Distribution of hyoscyamine and scopolamine in Datura stramonium

Miraldi, Elisabetta; Masti, Alessandra; Ferri, Sara; Comparini, I. Barni

doi:10.1016/s0367-326x(01)00291-x

Cited by 134 publications

(63 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparativement aux données rapportées dans la littéra-ture sur la composition en alcaloïdes tropaniques du Datura [7] 303/94 stramonium L., les résultats obtenus dans ce travail (prédomi-nance de l'atropine et de la scopolamine) sont en accord avec ceux obtenus en Bulgarie [8,9], en Italie [17] et en Afrique du Sud [18]. En revanche, ces résultats montrent des différences …”

Section: Résultats Cl/sm Et Discussionunclassified

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

et al. 2009

View full text Add to dashboard Cite

Résumé -Introduction : Datura stramonium L., du nom local Chdeq ej-jmel, est utilisé en médecine traditionnelle marocaine. Matériels et méthodes : L'extrait organique issu des graines sèches réduites en poudre de Datura stramonium L. récoltées dans la région de Kénitra (ouest marocain) a été analysé par chromatographie gazeuse couplée à la spectrométrie de masse. Résultats : L'analyse a permis l'identification de huit alcaloïdes tropaniques, dont le 6-hydroxyatropine et le 6-hydroxyapoatropine qui sont détectés pour la première fois dans les graines de cette espèce. Par ailleurs, les analyses en chromatographie liquide couplée à la spectrométrie de masse ont confirmé que l'atropine et la scopolamine sont les alcaloïdes majoritaires. Discussion et conclusion : Ces deux agents antimuscariniques sont responsables, selon la dose, de sédation ou de délires hallucinatoires recherchés par les usagers. Mots clés : Datura stramonium L., graines, alcaloïdes tropaniques, CPG-SM, CLHP-SM Abstract -Introduction: Datura stramonium L. (Chdeq ej-jmel)is a traditional medicine used in Morocco. Materials and methods: Qualitative analyses of the basic extract of tropane alkaloids in seeds of Datura stramonium L. collected in the region of Kénitra (west of Morroco) were carried out by GC/MS. Results and discussion: Eight tropane alkaloids were identified. Six of these alkaloids were described in previous works, and the other two (6-hydroxyatropine and 6-hydroxyapoatropine) are reported for the first time for this species in the present work. On the other hand, analyses by LC/MS confirmed that atropine and scopolamine are the main tropane alkaloids in seeds of Datura stramonium L. Conclusion: These two drugs are involved in the hallucinogenic and sedative effects of the plant.

show abstract

Section: Résultats Cl/sm Et Discussionunclassified

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

et al. 2009

View full text Add to dashboard Cite

show abstract

“…21 They are two main bioactive compounds found in several solanaceous plants, such as Scopolia tangutica Maxim., Datura stramonium Linn. and Anisodus tanguticus (Maxim.)…”

Section: Introductionmentioning

confidence: 99%

A non-aqueous solid phase extraction method for alkaloid enrichment and its application in the determination of hyoscyamine and scopolamine

Zhang

Wang

Guo

et al. 2012

Analyst

View full text Add to dashboard Cite

A non-aqueous solid phase extraction (SPE) method utilizing silica based strong cation exchange (SCX) was developed and optimized for the enrichment of alkaloids. In this method, silica based SCX SPE columns were used for the elimination of non-alkaloid compounds and the preconcentration of alkaloids from the extracts. Mass spectrometry was employed to analyze the alkaloid-enriched fraction, and results showed that the SPE method developed in this study was effective for the removal of non-alkaloids. Then, this pretreatment method was combined with high performance liquid chromatography for the quantification of scopolamine and hyoscyamine from Scopolia tangutica Maxim. The recoveries of scopolamine and (À)-hyoscyamine were 98.51% and 91.12%, respectively. Relative standard deviation values were 1.4% for scopolamine and 1.6% for (À)-hyoscyamine. The linearity was good in the 0.01-0.8 mg mL À1 range for hyoscyamine and 0.01-0.4 mg mL À1 range for scopolamine.

show abstract

“…The smoking of plant alkaloids was recommended as a therapy for asthma in the literature of Ayurvedic medicine as early as the 17th century (Gandevia, 1975;Jackson, 2010). Atropa belladonna and Datura stramonium are rich in anticholinergic alkaloids such as atropine and stramonium (Miraldi et al, 2001). These plants can be dried and smoked as a mechanism to deliver these agents to the airways.…”

Section: A Brief History Of Developmentmentioning

confidence: 99%