Distribution of human T‐lymphotropic virus type I among blood donors: a nationwide Brazilian study

Introduction: Human T cell lymphotropic virus types 1 and 2 (HTLV-1/2) are endemic in Brazil and are screened for in transfusion services since 1993. This study evaluated the evolution of the prevalence of HTLV-1 and 2 in blood donors of the Hemominas Foundation from 1993 to 2007, and its geographical distribution in State of Minas Gerais, Brazil. Methods: The Hemominas Foundation is a centralized blood center in Minas Gerais, Brazil. The sources of data were the Hemominas Foundation Technical Bulletin and files from the centralized serological laboratory. Donors were tested in the period using enzyme linked immuno sorbent assays (ELISA), followed by Western blot, when repeatedly reactive. The data were analyzed by EPIINFO 6.2 and TABWIN 3.5 softwares. Results: The average seroprevalence in the period 1993-2007 was 0.1%. A steady decline occurred from 0.4% in 1993 to below 0.1% in 2002 and later, with a transient peak of 0.5% in 1994. HTLV reactivity distribution was asymmetrical in the state, with regions of higher prevalence, interspersed with low prevalence areas. Comparison of positive and negative donors verified that increasing age was proportional to virus positivity. Odds ratio for age ranged from 1.43 (30 to 39 years-old) to 3.09 (50 to 65 years-old). Women had a greater chance of being positive (OR-1.64), as previously described. Conclusions: Possible explanations for HTLV-1/2 prevalence decline are the exclusion of positive donors from the donor pool, an increase in repeat donors and ELISA test improvement, with reduction in the number of false positive results.

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“…This prevalence was lower than that determined in 1993 by the same group (1.4%), showing a significant decline over this period 5 .…”

Section: Article/artigocontrasting

confidence: 66%

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Dias-Bastos

Oliveira

Carneiro-Proietti

2010

Rev. Soc. Bras. Med. Trop.

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“…[1][2][3][4] HTLV-1 infection is endemic in Brazil and, an estimation by the Ministry of Health 5 states that 750,000 people are carriers of HTLV, with a prevalence varying from 0.4% to 18% depending on the geographic region. [6][7][8][9][10] Psychiatric disorders appear to be common in patients with chronic diseases, as in tropical spastic paraparesis/HTLV-1 associated myelopathy (HAM/TSP). Besides, depression and anxiety symptoms may contribute to progressive disability and limitations in daily living activities impacting their perceptions about quality of life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of anxiety, depression and quality of life in HTLV-1 infected patients

Gascón¹,

Capitão²,

Casseb³

et al. 2011

Braz J Infect Dis

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The HAM/TSP caused by HTLV-1 infection usually affects patients to disabling states, and sometimes can lead them to paraplegia presenting symptoms of depression and anxiety, impacting on quality of life. Objective: The purpose of this study was to evaluate the frequency of depression and anxiety and its impact on quality of life in HTLV-1-infected TSP/HAM patients. Material and Methods: This was a cross-sectional study including 67 asymptomatic (control group) and 63 with TSP/HAM subjects. The instruments used were a demographic questionnaire, scales for anxiety and depression diagnosis (BDI and BAI), questionnaire for the assessment of Quality of Life of the World Health Organization (WHOQOL-Brief) and neurological scale to measure the disability level (Osame's Disability Status Scale). All patients had HTLV-I diagnosis by serological and molecular approaches, monitored at Instituto de Infectologia Emílio Ribas from May 2008 to July 2009. Data were analyzed statistically by frequencies, the Mann-Whitney test and the Spearman correlation test. Data among groups were analyzed and correlated with functional and severity aspects. Results: The results showed that patients with HAM/TSP compared to asymptomatic carriers had higher rates of depression (p < 0.001) and anxiety (p < 0.001), and impairment on quality of life in the areas of: dissatisfaction with health (p < 0.001), physical (p < 0.001) and the environment (p = 0.003). The main factors that correlated with levels of depression and anxiety and the domains of the WHOQOL-brief were: education, family income and social class. Conclusion: A well conducted evaluation and counseling may help in treatment, for a better quality of life of these patients.

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“…Por sua vez, a prevalência para o HTLV-I/II observada neste estudo (0,11%) tem posição intermediária entre aquela encontrada em Manaus (0,08%) 16 e em Belém (0,15%) 36 . No que diz respeito apenas ao vírus do tipo II, a prevalência de 0,03% foi maior do que aquela observada em Manaus (0%) 16 e em Belém (0,01%) 36 .…”

Section: Htlv-i/ii (N=219)unclassified

“…No que diz respeito apenas ao vírus do tipo II, a prevalência de 0,03% foi maior do que aquela observada em Manaus (0%) 16 e em Belém (0,01%) 36 .…”

Section: Htlv-i/ii (N=219)unclassified

Prevalência da infecção pelo vírus linfotrópico humano de células T e fatores de risco associados à soropositividade em doadores de sangue da cidade de Rio Branco, AC, Brasil (1998-2001)

Colin

Alcântara

Santos

et al. 2003

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 36(6): 677-683, nov-dez, 2003 Abstract Between December 1998 and March 2001, for each HTLV-I/II seropositive blood donor (ELISA, Abbott ® ), two HTLV-I/II seronegative blood donors were also chosen. The blood samples were re-tested by ELISA (Murex ® ), and those seropositives were also tested by Western Blot and PCR. Of the 11,121 blood samples, 73 (0.66%) were positives (Abbott ® ), but only 12 (0.11%) remained positives (Murex ® ), whereas the 146 seronegatives were confirmed, even though the concordance index between these two ELISA tests was hopeless. The Western Blot confirmed the twelve blood samples as seropositives: 8 (0.07%) HTLV-I; two (0.02%) HTLV-II and two (0.02%) indeterminate, being by PCR, one HTLV-I and the other HTLV-II. Concluding, in this Western Amazon population the HTLV-I/II seroprevalence was too low, in spite of the greater prevalence of HTLV-II expected due to a great indigenous racial mixture.

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Distribution of human T‐lymphotropic virus type I among blood donors: a nationwide Brazilian study

Cited by 161 publications

References 5 publications

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Prevalence of anxiety, depression and quality of life in HTLV-1 infected patients

Prevalência da infecção pelo vírus linfotrópico humano de células T e fatores de risco associados à soropositividade em doadores de sangue da cidade de Rio Branco, AC, Brasil (1998-2001)

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