Distribution of HLA-DRB1 and HLA-DQB1 alleles in Lak population of Iran

Varzi, Ali Mohammad; Shahsavar, Farhad; Tarrahi, Mohammadali

doi:10.1016/j.humimm.2016.05.011

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…KIR gene family is highly polymorphic and its genomic diversity is achieved through differences in gene content as well as allelic polymorphism [36], [37]. Of course the most polymorphic loci in human genome is HLA [38] which the molecules of its, are in direct contact with KIR molecules. Hereby we intend to investigate the role of the KIR genes in colorectal cancer as a meta-analysis to find the association of different genes of KIR and susceptibility to be affected by colorectal cancer.…”

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confidence: 99%

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

et al. 2016

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Colorectal cancer is one of the most common types of inflammation-based cancers and is occurred due to growth and spread of cancer cells in colon and/or rectum. Previously genetic association of cell cycle genes, both proto-oncogenes and the tumor suppressors has been proved. But there were few studies about association of immune related genes such as killer-cell immunoglobulin-like receptors (KIRs). Thus we intend to perform a meta-analysis to find the association of different genes of KIR and susceptibility to be affected by colorectal cancer. The overall population of the four studies investigated in our meta-analysis was 953 individuals (470 individuals with colorectal cancer and 483 individuals in control groups). After the analyses, we concluded that colorectal cancer is affected by KIR2DS5 and also there were no protecting gene. This result shows the inflammatory basis of this cancer. In other words, in contrast to leukemia and blood cancers, colorectal cancers seem to be affected by hyper activity of natural killer-cells (NKs). Whys and therefore of this paradox, is suggested to be investigated further.

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Section: Introductionmentioning

confidence: 99%

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

et al. 2016

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“…In previous studies, allele frequency of HLA class-II were determined in majority of different Iranian populations and compared with each other [18], [37]. In the present study, we intend to find allele frequency of HLA class-I in Lak/lᴂk/population of Lorestan province (west of Iran) regarding to the lack of this study (on the class-I) in Lak population.…”

Section: Introductionmentioning

confidence: 91%

“…Clinically, being acquainted with HLA distribution is a sine qua non for bone marrow donating centers [16], [17], forensic medicine [18], studies of HLA related disease such as type 2 diabetes [19], [20], [21] or multiple sclerosis [22], designing peptide vaccine and monoclonal antibodies against tumors [23], [24], infectious agents [25], [26], [27] and autoimmune disease [20], [28], as well as infertility treatment and assisted reproductive technologies [29], [30], [31].…”

Section: Introductionmentioning

confidence: 99%

A genomic study on distribution of human leukocyte antigen ( HLA ) -A and HLA-B alleles in Lak population of Iran

2017

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Anthropological studies based on the highly polymorphic gene, human leukocyte antigen (HLA), provide useful information for bone marrow donor registry, forensic medicine, disease association studies, as well as infertility treatment, designing peptide vaccines against tumors, and infectious or autoimmune diseases. The aim of this study was to determine HLA-A and HLA-B allele frequencies in 100 unrelated Lak/lᴂk/individuals from Lorestan province of Iran. Finally, we compared the results with that previously described in Iranian population. Commercial HLA-Type kits from BAG (Lich, Germany) company were used for determination of the HLA-A and HLA-B allele frequencies in genomic DNA, based on polymerase chain reaction with sequence specific primer (PCR-SSP) assay. The differences between the populations in distribution of HLA-A and HLA-B alleles were estimated by chi-squared test with Yate's correction. The most frequent HLA-A alleles were *24 (20%), *02 (18%), *03 (12%) and *11 (10%), and the most frequent HLA-B alleles were *35 (24%), *51 (16%), *18 (6%) and *38 (6%) in Lak population. HLA-A*66 (1%), *74(1%) and HLA-B*48 (1%), *55(1%) were the least observed frequencies in Lak population. Our results based on HLA-A and HLA-B allele frequencies showed that Lak population possesses the previously reported general features of Iranians but still with unique.

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“…Since uNKs are mainly CD16 -they are called as immune-regulatory NKs (against cytotoxic NKs); and since mostly CD56 dim is along with the presence of CD16 and CD56 bright and absence of CD16, the dim and bright types of NKs are respectively called as cytotoxic and immune-regulatory NKs (18). As we mentioned before, HLA genes are the most polymorphic loci in the human genome that is very useful in anthropological studies (19) as well as infertility screenings. In addition to the HLAs, about 14 types of killer-cell immunoglobulin-like receptor (KIR) have been discovered so far on the surface of NKs.…”

Section: Introductionmentioning

confidence: 99%

“…Of course such molecules have variety of kinds and the mentioned references (53,55,56) are not merely related to endometrium and it's upon us to study further. Also L-selectin is abundant on cell surface of CD56 bright NKs (19); so inhibiting these NKs as a therapeutic protocol by aspirin needs to be investigated further. The inflammatory response of T-helper-1 cells and T-helper-2 cells are respectively necessary for induction of implantation and pregnancy maintenance (59).…”

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A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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IntroductionAmong the controversies in reproduction science, role of immune and inflammatory systems in implantation process and durability of pregnancy is a hot topic nowadays. Some researchers and practitioners believe that administration of drugs such as prednisolone, aspirin or heparin can improve success rate of implantation and pregnancy through inhibiting coagulation, inflammatory and immune systems; while others believe that such systems not only do not have negative effect on rejecting blastocyst and embryo by itself but also are necessary for implantation and remodeling of uterine spiral arteries through secreting adhesive and angiogenic factors. Such controversies are proposed both in natural pregnancies resulting in spontaneous abortion as well as in successful and/or unsuccessful assisted reproductive technologies (ARTs). Recurrent spontaneous abortion (RSA) is defined as having 3 or more history of abortion (1). About the other issue, some researchers and practitioners are grumbling of low success rate of ARTs like in vitro fertilization (IVF). Infertility is a problem for 10%-15% of couples; most of which -but not all -require ART (2). The average fertilization rate of ART in previous researches has been reported about 30% (3) and this report is for 1998. It has been claimed in an article published in 2015 that this rate has improved in the recent decade (4). Even though at the first glance this rate seems low, but the interesting point is that in the claim of a valid reference (5) the chance of natural pregnancy for each intercourse per month does not go up more than 33%. Also this number has been reported in some studies up to 40% (6). Thus, we should not be grumbling of the low fertilization rate of ARTs. Finally we intend to represent and report our insights, reasoning and suggestions in the present review. MethodsThis systematic and critical review includes investigation of scientific data bases and tracing the citations and the references of the articles in order to find the root of the truth. Through this wisdom, we showed the mere that a content proposed in an indexed article is not a reason that this content is valid and able to be cited. Indeed, the researcher should regard and notice the reasoning, citations and protocol of his/her references during the literature review. This is the benefit point of systematic review rather than holistic and narrative reviews. Since some data were few, the time period of publications was not important to us. As the searching strategy, we used the Web of Science Core Collection and Google Scholar for finding articles other than ISI-WOS and the tracing mentioned in the above paragraph. Results and DiscussionRole of Immune System and Leukocytes In 2015, Ghafourian et al (1) by measuring the level of natural killer-cells (NKs) in blood of the RSA and the control group concluded that RSA patients in normal (non-preg- AbstractAmong the controversies about reproduction sciences, role of immune and inflammatory systems in implantation process and durability of...

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Distribution of HLA-DRB1 and HLA-DQB1 alleles in Lak population of Iran

Cited by 14 publications

References 13 publications

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

Colorectal cancer and the KIR genes in the human genome: A meta-analysis

A genomic study on distribution of human leukocyte antigen ( HLA ) -A and HLA-B alleles in Lak population of Iran

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

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