Distribution of high-risk HPV types among women in Sichuan province, China: a cross-sectional study

Abstract

Background Persistent infection with high-risk human papillomavirus (HR-HPV) is a major cause of cervical intraepithelial neoplasia and invasive cervical cancer. We investigated the prevalence of HR-HPV infection and distribution of viral genotypes among women in this area. Methods Women in Sichuan older than 20 years were screened for cervical cancer between January 2015 and December 2016 using liquid-based cytology testing and a flow cytometry-fluorescence hybridization test for HPV-DNA. Frequency tables were evaluated using the chi-squared test (χ 2 ). Results Of the 17,319 women aged 20–85 years who participated in the study, Overall prevalence of HR-HPV infection was 12.6% (2178/17,319). The most prevalent viral type was HPV-52, which was present in 2.5% of individuals, followed by HPV-53 (1.6%), HPV-58 (1.5%), HPV-16 (1.1%), HPV-56 (0.9%), HPV-39 (0.8%). In HSIL, the five most common HR-HPV types were HPV52, 16, 58, 33 and 56. HPV16/18 in HSIL only makes up 25.9% of HSIL, whereas HPV31/33/45/52/58 make up 56.8%. Overall HR-HPV prevalence among women older than 65 years was 15.2%, significantly higher than the prevalence in other age groups ( P < 0.05). Infection with dual or multiple HR-HPV types was associated with greater risk of abnormal cytology. Conclusion Overall HR-HPV prevalence in Sichuan is as high as in large cities in China. The HR-HPV types 52, 16, 58, 33 and 56 predominated in this sample of HSIL women primarily from the banking and public sector in Sichuan. High prevalence among women older than 65 years needed pay attention to.

Prevalence and genotype distribution of HPV and cervical pathological results in Sichuan Province, China: a three years surveys prior to mass HPV vaccination

“…By further analyzing of population, we found HPV infection prevalence of HEC group is significantly lower than that of OGOC group, which is 15.29% and 37.62% respectively. Among the HPV studies related to Sichuan Province, there is only one focused on the HEC population, and the prevalence of HPV infection is 12.6% [9]. But this study only calculated the high-risk HPV, which may result in the lower prevalence rate than ours.…”

“…The prevalence of neighboring southwest provinces is 26.2% in Chonqing, 16.95% in Guizhou, 12.9% in Yunnan [16][17][18]. For Sichuan, the fourth largest population province located in southwestern China, several studies have investigated its HPV epidemiology and genotype distribution, but the HPV infection prevalence varies, ranging from 10.15-31.3% [7][8][9][10][11][12]. In our study, the HPV infection prevalence of the total population is 23.84%, which is basically consistent with the result of Li et al (24.1%) [12].…”

“…Recently years, several studies aimed to investigate the epidemiology and genotype distribution of HPV in this area. However, the results varies in different studies [7][8][9][10][11][12].…”

Human Papillomavirus: Six years genotype distribution of a hospital-based population study in women in Chongqing, China

“…The HPV infection rate in the Health Management Center was 14.4% which was lower than that in Guangdong (17.25%) [20]. The prevalence of HR-HPV infection was 11.7%, which was nearly similar to that in Sichuan (12.6%) [21]. The cause of this may be the close geographical location of Chongqing and Sichuan and the similar laboratory detection methods.…”

“…We hypothesize that this variation maybe because of the study period and participants. The most prevalent types of HR-HPV infection in Health Management Center were HPV52, 58, 53, 16 in this order, different from the types in Sichuan (HPV52, 53, 58, 16 in this order) [21]. Some studies have reported that HPV 52 and 58 were more dominant genotypes and relate to cervical cancer occurrence in the Asian population [22][23][24].…”