Distribution of Hepatitis C Virus Genotypes among Azerbaijani Patients in Capital City of Iran-Tehran

Bokharaei‐Salim, Farah; Keyvani, Hossein; Monavari, Seyed Hamidreza; Alavian, Seyed Moayed; Fakhim, Shahin Abdollahi; Nasseri, Sherko

doi:10.5812/hepatmon.13699

Cited by 21 publications

(21 citation statements)

References 36 publications

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“…This finding was consistent with a recent study performed in Tehran (a city near Zanjan) ( 22 ). It was also comparable with the obtained results reported ( 25 ) from Azerbaijani patients (in West Azerbaijan, Northwest of Iran) with established chronic hepatitis C, who referred to some hospitals in Tehran ( 26 ). This similarity may be due to the proximity of Zanjan with these cities.…”

Section: Discussionsupporting

confidence: 91%

Serological Assay and Genotyping of Hepatitis C Virus in Infected Patients in Zanjan Province

et al. 2014

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Background:Hepatitis C Virus (HCV), a public health problem, is an enveloped, single-stranded RNA virus and a member of the Hepacivirus genus of the Flaviviridae family. Liver cancer, cirrhosis, and end-stage liver are the outcomes of chronic infection with HCV. HCV isolates show significant heterogeneity in genetics around the world. Therefore, determining HCV genotypes is a vital step in determining prognosis and planning therapeutic strategies.Objectives:As distribution of HCV genotypes is different in various geographical regions and HCV genotyping of patients has not been investigated in Zanjan City, this study was designed for the first time, to determine HCV genotypes in the region and to promote the impact of the treatment.Materials and Methods:Serum samples of 136 patients were collected and analyzed for anti-HCV antibodies using ELISA (The enzyme-linked immunosorbent assay) method. Then, positive samples were exposed to RT-PCR, which was performed under standard condition. Afterwards, they investigated for genotyping using allele-specific PCR (AS-PCR), and HCV genotype 2.0 line probe assay (LiPA).Results:Samples indicated 216 bp bands on 2% agarose gel. Analyses of the results demonstrated that the most dominant subtype was 3a with frequency of 38.26% in Zanjan Province followed by subtypes of 1b, 1a, 2, and 4 with frequencies of 25.73%, 22.05%, 5.14%, and 4.41%, respectively. The frequency of unknown HCV genotypes was 4.41%.Conclusions:According to the results, it was found that HCV high prevalent genotype in Zanjan is subtype 3a. Analysis of the results provides identification of certain HCV genotypes, and these valuable findings could affect the type and duration of the treatment.

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Section: Discussionsupporting

confidence: 91%

Serological Assay and Genotyping of Hepatitis C Virus in Infected Patients in Zanjan Province

et al. 2014

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“…In the present study, the predominant genotype among HCV-infected patients was G3a which is in contrast with other studies enrolled in Iran, introducing mostly G1a as the most prevalent genotype of HCV [46][47][48]. However, this finding is consistent with Taherkhani et al [23] pointing out an increase in the frequency of infection with G3a in recent years and geographic predominance of this genotype in some parts of Iran.…”

Section: Discussionsupporting

confidence: 65%

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

Sadeghi

Vasmehjani

Baharlou

et al. 2019

J Infect Dev Ctries

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Introduction: The interleukin 28B (IL28B) genotype is associated with changes of lipid metabolism in patients infected with hepatitis C virus (HCV). The association of steatosis with serum levels of adiponectin in chronic hepatitis C (CHC) patients has also been documented. This study aimed for the evaluation of serum levels of IL28B and adiponectin as well as the association of IL28B SNPs with different clinicopathological parameters in HCV-infected patients. Methodology: All 142 HCV-infected patients received peg-interferon plus ribavirin. Detection of rs8099917 and rs12979860 IL-28B genotypes was done with specific primers. Serum IL28 and adiponectin levels were measured using commercial ELISA kits. Results: Higher levels of both IL28 and adiponectin were found in patients. In Genotype 3a (G3a) -infected patients, IL28 and adiponectin serum levels were significantly higher than those infected with G1a. A correlation was found between increasing levels of AST and ALT in G3a-infected patients and the decrease in IL28 and adiponectin serum levels, respectively, in contrast to G1a-infected patients. Higher levels of both IL28 and adiponectin were associated with both CT allele of rs12979860 and TT allele of rs8099917 in patients in comparison with corresponding alleles in controls. Conclusions: In contrast to other studies, this study showed higher serum adiponectin levels in HCV-infected patients compared to that in healthy controls. This finding is possibly due to adiponectin resistance caused by down-regulation of adiponectin receptors or tumorigenic effects of adiponectin. Our genotype-based analyses revealed, at least in part, the involvement of the viral factors in the outcome of HCV infection.

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“…When we look at the countries surrounding Iran, we encounter a high variation in the distribution of HCV genotypes despite their close proximity and even being neighbors. For example, in Turkey, Uzbekistan, and Russia, subtype 1b was common (22); in Pakistan, HCV genotype 3 was the most prevalent (23); and in Saudi Arabia and Iraq, genotype 4 was predominant (24). The difference in the distribution of HCV genotypes and subtypes between Iran and its neighbors may indicate that HCV in Iran originated form a non-neighboring country.…”

Section: Discussionmentioning

confidence: 99%

The Distribution of Hepatitis C Virus Genotypes in Middle Eastern Countries: A Systematic Review and Meta-Analysis

et al. 2016

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ContextThe hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to review systematically all studies reporting the distribution of HCV genotypes in the countries that make up the Middle East.Evidence AcquisitionArticles were identified by searching electronic databases, including Scopus, PubMed and Google scholar, with timeline limits (articles published between 1995 and 2016). We carried out a systematic search regarding the distribution of HCV genotypes in Middle Eastern countries.ResultsA total of 579 studies were identified by the electronic search. Of these, a total of 187 were identified as eligible papers including 60,319 patients who were meta-analyzed for pooled distribution of HCV genotypes. In Turkey, Israel, Cyprus, and Iran, genotype 1 was the most prevalent HCV genotype with rates of 82% (95% CI, 82%-83%), 68% (95% CI, 67%-69%), 68% (95% CI, 59%-77%), and 55% (95% CI, 54%-55%), respectively. In Egypt, Iraq, Saudi Arabia, and Syria, HCV genotype 4 was the most common genotype with rates of 86% (95% CI, 85%-88%), 60% (95% CI, 56%-64%), 56% (95% CI, 54%-55%), and 57% (95% CI, 54%-61%), respectively. On the basis of adjusted data, HCV genotype 4 was the most prevalent genotype in the Middle East region, with a rate of 74.7% (95% CI, 73.4%-76%), followed by genotype 1 at 15.1% (95% CI, 14.1%-16%).ConclusionsOur results showed that HCV genotype 4 is the most prevalent genotype in the Middle East region. However, HCV genotype 1 is the most prevalent among non-Arab countries in the region including Turkey, Iran, Cyprus, and Israel.

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Distribution of Hepatitis C Virus Genotypes among Azerbaijani Patients in Capital City of Iran-Tehran

Cited by 21 publications

References 36 publications

Serological Assay and Genotyping of Hepatitis C Virus in Infected Patients in Zanjan Province

Serological Assay and Genotyping of Hepatitis C Virus in Infected Patients in Zanjan Province

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

The Distribution of Hepatitis C Virus Genotypes in Middle Eastern Countries: A Systematic Review and Meta-Analysis

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