Serological Assay and Genotyping of Hepatitis C Virus in Infected Patients in Zanjan Province

Esmaeilzadeh, Abdolreza; Erfanmanesh, Maryam; Ghasemi, Sousan; Mohammadi, Farzaneh

doi:10.5812/hepatmon.17323

Cited by 16 publications

(1 citation statement)

References 37 publications

(32 reference statements)

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“…Genotype 6 prevails in Hong Kong and Vietnam. 36 In our study, male dominance was observed with seropositivity of 63.63% and is in agreement with the studies from Uttarakhand, Delhi, and Haryana. 37,38 Another study from Delhi revealed the male preponderance with overall male to female ratio of 1.5:1.…”

Section: Discussionsupporting

confidence: 92%

Epidemiology and Genotypes of Hepatitis C Virus: A First Study from Jammu (J & K), India

Sharma¹,

Sharma²,

Sehgal³

et al. 2017

Journal of Gastrointestinal Infections

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Background and objectives: Globally, around 200 million people are infected with hepatitis C virus (HCV). India contributes a big proportion of HCV burden with the prevalence estimated between 0.5 and 1.5%. Northeastern tribal populations and areas of Punjab represent the HCV infection hotspots, while in Western and Southern parts of the country, the prevalence is lower. The distribution of HCV genotypes is highly variable. This study was particularly planned to attain knowledge of the prevalent HCV genotypes in Jammu province of Jammu and Kashmir (J&K) state. Materials and methods:Blood samples of patients attending the Department of Medicine, Government Medical College (GMC), Jammu and Kashmir, India, for HCV testing were subjected to serological test at Department of Microbiology, GMC, Jammu. The serum samples were tested for anti-HCV antibodies by enzyme-linked immunosorbent assay (ELISA) and positive samples were subjected to genotyping. Conclusion:Of the 396 samples tested, 33 (8.33%) were found to be HCV positive and 23 of these were included for genotyping. Genotypes 3 and 1 were detected in this region and this was in accordance with other national studies. There is a need for larger field studies to better understand the HCV epidemiology and identify higher prevalence areas and also the distribution of genotypes of HCV. This, being a maiden study from this region, will shed light to allow apposite choice and target efforts for better management of the disease and reduce the burden of chronic liver disease due to HCV.

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Section: Discussionsupporting

confidence: 92%