Distribution of haemoglobin genotypes, knowledge, attitude and practices towards sickle cell disease among unmarried youths in the Buea Health District, Cameroon

Ngwengi, Nini Yesih; Fon, Peter Nde; Mbanya, Dora

doi:10.11604/pamj.2020.37.109.17864

Cited by 4 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This analysis also showed a high level of heterogeneity with statistically significant (< 0.001) variation among the included studies. While we have previously observed a relationship between SCD awareness and SCTS, the reverse is the case in Cameroon, where the respondents had a considerable knowledge of SCD, yet the practice of genotype screening was poor [21]. The lack of translation of knowledge of SCD to uptake of genotype screening may be linked to socioeconomic factors such as poverty and poor access to screening services.…”

Section: Pe-riodmentioning

confidence: 70%

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Dilli,

Obeagu,

Tamale

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

Background Screening for sickle cell traits before marriage or producing children is one of the outstanding preventive measures for sickle cell disease (SCD).The disease is a collection of inherited blood disorders that impact millions globally, with a predominant 75% occurrence in the sub-Saharan region. With increasing burden of SCD on the continent amidst a cost effective prevention method, no study has systematically reviewed or presented meta-analytic uptake or practice of premarital sickle cell trait screening. Methods This review systematically explored the uptake or practice of premarital genotype screening in Africa. We searched PubMed and Scopus databases for African studies on premarital screening for sickle cell traits. Results Our results indicate that the pooled uptake of premarital sickle cell trait screening in Africa is 47.82% (95% CI: [46.53–49.11]; I2: 98.95% [98.74–99.13]). Our review observed, a significant relationship between the awareness of sickle cell disease and the uptake of genotype screening; F(1, 13) = 12.04, p = 0.004). The model explained approximately 48.08% of the variation in genotype screening (R² = 0.4808) and predicted a 0.729 increase in the likelihood of genotype screening uptake for every unit rise in sickle cell disease awareness (β = 0.729, p = 0.004). Additionally, Pearson correlation (r = 0.6934) indicated a moderately strong positive correlation between the two variables. Conclusion With over 75% of the global burden of sickle cell disease domiciled in Africa, the continent cannot overlook the cost of hemoglobinopathies. The uptake of sickle cell traits screening is suboptimal across the continent. To achieve the mandate of sustainable development goal number (3); to end preventable deaths of newborns and children under 5 years of age by 2030, there is need to intensify campaigns on premarital genetic screening through education and other health promotion tools.

show abstract

Section: Pe-riodmentioning

confidence: 70%

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Dilli,

Obeagu,

Tamale

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

“…This small pilot ( n = 180) did not detect any cases of CH and concluded that a larger study was necessary to determine the potential for NBS in the country [ 1487 ]. And a 2020 article on knowledge, attitudes, and practices towards SCD in unmarried youths recommended NBS for SCD as a needed preventive method [ 1488 ]. The Fondation Pierre Fabre and partners from Cameroon and three Central African countries (Côte d’Ivoire, Democratic Republic of Congo, Central African Republic and) have designed a project to support the fight against SCD.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

Therrell,

Padilla,

Borrajo

et al. 2024

IJNS

View full text Add to dashboard Cite

Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr. Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for phenylketonuria on blood absorbed onto a special filter paper and transported to a remote testing laboratory began it all. Expansion of NBS to large numbers of asymptomatic congenital conditions flourishes in many settings while it has not yet been realized in others. The need for NBS as an efficient and effective public health prevention strategy that contributes to lowered morbidity and mortality wherever it is sustained is well known in the medical field but not necessarily by political policy makers. Acknowledging the value of national NBS reports published in 2007, the authors collaborated to create a worldwide NBS update in 2015. In a continuing attempt to review the progress of NBS globally, and to move towards a more harmonized and equitable screening system, we have updated our 2015 report with information available at the beginning of 2024. Reports on sub-Saharan Africa and the Caribbean, missing in 2015, have been included. Tables popular in the previous report have been updated with an eye towards harmonized comparisons. To emphasize areas needing attention globally, we have used regional tables containing similar listings of conditions screened, numbers of screening laboratories, and time at which specimen collection is recommended. Discussions are limited to bloodspot screening.

show abstract

“…28,34 Poor knowledge about sickle cell disease was identified amongst unmarried youths in Cameroon. 35 In Nigeria, poor knowledge about sickle cell disease has also been reported among secondary school students, 36,37 undergraduates, 1,38,39 local government workers, 40 and childbearing-age adult women. [41][42][43] Level of education has been reported as a determinant of good knowledge about sickle cell disease.…”

Section: Knowledge About Sickle Cell Diseasementioning

confidence: 99%

A Critical Review of Sickle Cell Disease Burden and Challenges in Sub-Saharan Africa

Adigwe¹,

Onoja²,

Onavbavba³

2023

JBM

View full text Add to dashboard Cite

Sickle cell disease is caused by an abnormality of the β-globin gene and is characterised by sickling of the red blood cells. Globally, sub-Saharan African countries share the highest burden of the disease. This study aimed at critically reviewing studies focusing on challenges of sickle cell anaemia in sub-Saharan Africa. A literature search was carried out in five major databases. Articles that met the inclusion criteria were included in the bibliometric review and critical analysis. A majority of the studies were undertaken in the West African region (85.5%), followed by Central Africa (9.1%). Very few studies had been undertaken in East Africa (3.6%), whilst the Southern African region had the fewest studies (1.8%). Distribution in relation to country revealed that three quarters of the studies were carried out in Nigeria (74.5%), followed by the Democratic Republic of the Congo (9.1%). According to healthcare settings, a strong majority of the studies were undertaken in tertiary health care facilities (92.7%). Major themes that emerged from the review include interventions, cost of treatment, and knowledge about sickle cell disease. Public health awareness and promotion as well as improving the quality of sickle cell centers for prompt management of patients with sickle cell disorder was identified as a critical strategy towards reducing the burden of the disease in sub-Saharan Africa. To achieve this, governments in countries located in this region need to adopt a proactive strategy in addressing gaps that have been identified in this study, as well as instituting other relevant measures, such as continuous media engagement and public health interventions relating to genetic counselling. Reforms in other areas that can help reduce the disease burden, include training of practitioners and equipping sickle cell disease treatment centers according to World Health Organization specifications.

show abstract

Distribution of haemoglobin genotypes, knowledge, attitude and practices towards sickle cell disease among unmarried youths in the Buea Health District, Cameroon

Cited by 4 publications

References 12 publications

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

A Critical Review of Sickle Cell Disease Burden and Challenges in Sub-Saharan Africa

Contact Info

Product

Resources

About