Distribution of fluoride in cortical bone of human rib

Abstract

We describe a detailed study of fluoride distribution with age in the human cortical rib bone. Human ribs were obtained from 110 subjects (M:68, F;42) aged 20-93 years. The fluoride distribution from the periosteal to endosteal surfaces of the ribs was determined by sampling each specimen using an abrasive micro-sampling technique, and the samples were analyzed using the fluoride electrode, as described by Weatherell et al. [1]. The concentration of fluoride was highest in the periosteal region, decreased gradually towards the interior of the tissue where the concentration of fluoride tended toward the plateau, and then rose again towards the endosteal surface. Patterns of fluoride distribution changed with age, and the difference between periosteal and endosteal fluoride levels increased with age. Although average fluoride concentrations increased with age in both sexes, there was a significant difference between males and females at the age of about 55 years (P < 0.05).

Differences in Skeletal Kinetics Between Vertebral and Humeral Bone Measured by 18F-Fluoride Positron Emission Tomography in Postmenopausal Women

“…(3,21) In animals and human pathological specimens fluoride has been shown to be preferentially deposited at bone surfaces where remodeling is greatest. (19,20) Plasma clearance of fluoride to bone mineral (Ki) and unidirectional plasma clearance to total bone tissue (K1) are significantly greater in the lumbar spine, which is a predominantly trabecular site compared with the humeral shaft, which is predominantly cortical. We have found Ki to be on average 2.1 times greater in the lumbar spine.…”

“…(18) Fluoride is preferentially deposited at the surfaces of bone where remodeling and turnover is greatest. (19,20) Employing plasma clearance methods, this tracer has been used to measure total skeletal blood flow, which has been shown to correlate with osteoblast work rate in iliac trabeculae and skeletal influx rate of calcium in osteoporotic patients. (21) The aim of the present study was to measure and compare regional skeletal kinetics at sites consisting of either predominantly trabecular or cortical bone, using 18 F-fluoride PET in nonosteoporotic postmenopausal women.…”

A Prospective Study of Risedronate on Regional Bone Metabolism and Blood Flow at the Lumbar Spine Measured by18F-Fluoride Positron Emission Tomography

“…This has been confirmed by Piert et al (35) using a dual tracer study. They reported a highly significant relationship (r ϭ 0.93) between "true" blood flow assessed by 15 O-H 2 O and K 1 assessed by 18 F-fluoride PET in both normal and gastrectomized pigs. (32) This relationship, indicating a unidirectional extraction efficiency close to 100%, was found for low and normal flow rates; however, this progressively decreased with increasing flow, so that for blood flows above 0.2-0.35 ml/min/ml, the magnitude of K 1 was increasingly independent of blood flow as diffusion limits tracer transport.…”

“…(14) The rapid uptake of 18 F-fluoride occurs preferentially at sites of high osteoblastic activity where bone remodeling is greatest. (15,16) Reeve et al, (7) using plasma clearance techniques, used 18 F-fluoride to measure skeletal blood flow, and this was found to correlate with osteoblastic activity in the iliac crest measured by bone histomorphometry. Using the threecompartmental model first described by Hawkings et al (9 -12,17-19) to analyze 18 F-fluoride PET studies, several studies have recently been published describing regional skeletal metabolism in the axial skeleton.…”

Quantification of Skeletal Kinetic Indices in Paget's Disease Using Dynamic18F-Fluoride Positron Emission Tomography

“…(9) Fluoride is preferentially deposited at the surfaces of bone where remodeling and turnover is greatest. (10,11) Employing plasma clearance methods, this tracer has been used to measure total skeletal blood flow, which correlates with osteoblast work rate in iliac trabeculae and skeletal influx rate of calcium in osteoporotic patients. (12) In subjects with renal osteodystrophy, clearance of 18 F-fluoride to bone mineral has been shown to correlate with biochemical and histomorphometric indices of bone formation.…”