“…18 Ffluoride PET has been used to investigate regional bone metabolism in patients with metabolic bone disease (23,24,28,31,33) and to evaluate therapies for these diseases (30,33). In addition, important differences in remodeling activity between cortical and trabecula-rich sites can be investigated (26). 18 F-fluoride PET may also have an important role in the investigation of neovascularization after allogenic bone grafting, periprosthetic bone formation after joint replacement (35)(36)(37), and fracture healing (38).…”