Distribution of fluoride concentration in the rat's bone

Abstract

The present study was undertaken to determine the fluoride distribution profile in the rat femur. Male Wistar rats were divided into four groups and given water containing 0, 25, 50, and 100 ppm of fluoride, respectively, for 10 weeks. The fluoride distribution from the periosteum to the endosteum was determined in each specimen after sampling using the abrasive microsampling technique. In the outer circumferential lamellae, the concentration of fluoride was relatively high in the periosteal layer and then decreased gradually towards its interior. In the haversian and interstitial lamellae, it was lower and roughly constant through the tissue. In the inner circumferential lamellae, it rose again to reach the highest level towards the endosteal surface. Fluoride concentration throughout the cortex increased significantly with increasing intake of fluoride. These increases were especially marked at periosteal and endosteal surfaces.

Differences in Skeletal Kinetics Between Vertebral and Humeral Bone Measured by 18F-Fluoride Positron Emission Tomography in Postmenopausal Women

“…(3,21) In animals and human pathological specimens fluoride has been shown to be preferentially deposited at bone surfaces where remodeling is greatest. (19,20) Plasma clearance of fluoride to bone mineral (Ki) and unidirectional plasma clearance to total bone tissue (K1) are significantly greater in the lumbar spine, which is a predominantly trabecular site compared with the humeral shaft, which is predominantly cortical. We have found Ki to be on average 2.1 times greater in the lumbar spine.…”

“…(18) Fluoride is preferentially deposited at the surfaces of bone where remodeling and turnover is greatest. (19,20) Employing plasma clearance methods, this tracer has been used to measure total skeletal blood flow, which has been shown to correlate with osteoblast work rate in iliac trabeculae and skeletal influx rate of calcium in osteoporotic patients. (21) The aim of the present study was to measure and compare regional skeletal kinetics at sites consisting of either predominantly trabecular or cortical bone, using 18 F-fluoride PET in nonosteoporotic postmenopausal women.…”

A Prospective Study of Risedronate on Regional Bone Metabolism and Blood Flow at the Lumbar Spine Measured by18F-Fluoride Positron Emission Tomography

“…(14) The rapid uptake of 18 F-fluoride occurs preferentially at sites of high osteoblastic activity where bone remodeling is greatest. (15,16) Reeve et al, (7) using plasma clearance techniques, used 18 F-fluoride to measure skeletal blood flow, and this was found to correlate with osteoblastic activity in the iliac crest measured by bone histomorphometry. Using the threecompartmental model first described by Hawkings et al (9 -12,17-19) to analyze 18 F-fluoride PET studies, several studies have recently been published describing regional skeletal metabolism in the axial skeleton.…”

Effects of Alendronate on Bone Metabolism in Glucocorticoid-Induced Osteoporosis Measured by18F-Fluoride PET: A Prospective Study

“…The preferential rapid uptake of 18 F-fluoride reflects sites of high osteoblastic activity related to bone remodeling (15,16). Furthermore, 18 F-fluoride has been used to measure bone blood flow, and a significant correlation was reported between 18 F-fluoride uptake and osteoblastic activity, as determined by bone morphometry (17).…”