Distribution of epithelial membrane antigen in normal and neoplastic human ependyma

Uematsu, Yoshihiko; Rojas–Corona, R. R.; Llena, J. F.; Hirano, Atsushi

doi:10.1007/bf00687763

Cited by 39 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The basis for this observation remains to be determined. Using staining for EMA, ependymomas are known to show small round, dot-like, or granular positive structures within tumor cell cytoplasm [1,11], and Hirato et al [5] confirmed that these EMA-positive intracytoplasmic structures were microlumina using electron microscopy. Thus, Immunostaining for both EMA and GFAP seems a useful tool for identifying IEIs in ependymoma.…”

Section: Discussionmentioning

confidence: 89%

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study

Kawano¹,

Ohba

Nagashima

2000

Acta Neuropathol

View full text Add to dashboard Cite

A study was undertaken to determine the pathological significance of previously unrecognized intracytoplasmic eosinophilic inclusions (IEIs) in ependymoma. The study group consisted of 58 ependymomas, all of which were pathologically characterized and graded according to the 1993 WHO classification. Electron microscopic studies were performed in 16 cases. The study showed that 33 (57%) ependymomas had IEIs and that in 8 cases these were abundant. Round and eosinophilic, their sizes varied from 10 microns to a tiny dot. Similar eosinophilic bodies were also observed between tumor cells. The inclusions were weakly PAS positive. On immunostains, IEIs were frequently positive for glial fibrillary acidic protein, less often for S-100 protein, and for epithelial membrane protein and CAM 5.2. They were negative for AE1/AE3, carcinoembryonic antigen and Ber-EP4. Ultrastructurally, IEIs represented intracytoplasmic lumens containing microvilli and cilia. These microlumina also frequently contained granulo-tubular materials. With reference to tumor subtypes, IEIs occurred most frequently in ordinary and clear cell ependymomas. IEIs were also present in 4 of 6 anaplastic ependymomas studied. In conclusion, IEIs represent microlumina and occur in more than a half of ependymomas including malignant examples. Their finding is a helpful diagnostic feature of ependymoma.

show abstract

Section: Discussionmentioning

confidence: 89%

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study

Kawano¹,

Ohba

Nagashima

2000

Acta Neuropathol

View full text Add to dashboard Cite

show abstract

“…However, cases have been reported in neonates as well as patients in the eighth decade 3,24,28. Both female and male predominance have been reported 3,29…”

Section: Discussionmentioning

confidence: 99%

Posterior Fossa Neurenteric Cysts Can Expand Rapidly: Case Report

Priamo

Jimenez²,

Benardete

2011

Skull Base Rep

View full text Add to dashboard Cite

Neurenteric cysts are considered congenital lesions that may slowly expand over time. Although more commonly found in the spinal canal, they may be found intracranially, particularly in the posterior fossa. Here, we present an unusual case of a large, rapidly expanding histologically confirmed posterior fossa neurenteric cyst in a 53-year-old woman, who presented with quadriparesis. Computed tomography imaging done ~1.5 years before admission failed to demonstrate any obvious abnormality; however, the lesion had grown to 4 cm in maximal dimension at presentation with significant mass effect. The lesion was resected microsurgically using a retrosigmoid approach. The patient improved postoperatively and was neurologically intact at last follow-up. We could find no other documented case of marked, rapid expansion of a neurenteric cyst in the literature. We conclude that, although neurenteric cysts are thought to be congenital, they can undergo rapid expansion even in adults. The mechanism of expansion is unknown but may involve increased secretion, hemorrhage, or inflammation. We discuss the surgical management and review the literature in view of this surprising finding.

show abstract

“…The subsequent immunohistochemical and ultrastructural studies easily disclosed the ependymal features of the glial tumor cells: EMA-immunoreactive granular or microvesicular structures were evident in the GFAP-positive background [4,9,27,28], and there were microvilliand cilia-lined lumina and long junctional complexes [9,11,23,27]. Although the new WHO classification does not recognize tanycytic ependymomas as a subtype [12], they are given many lines in some widely read books [3,14,24].…”

Section: Discussionmentioning

confidence: 99%

Ganglioglioma with a tanycytic ependymoma as the glial component

Hayashi¹,

Kameyama

Fukuda

et al. 2000

Acta Neuropathol

View full text Add to dashboard Cite

We studied a cystic ganglioglioma (GG) located in the right frontal lobe of the brain. Interestingly, the fibrillary spindle glial cells were often arranged in a fascicular pattern, and the generally uniform, round-to-oval delicate nuclei appeared to resemble those of ependymoma; and the neoplastic neurons often contained neurofibrillary tangles (NFTs). The glial component was positive for glial fibrillary acidic protein and occasionally contained granular or microvesicular structures positive for epithelial membrane antigen. Ultrastructural investigation revealed that the glial cells were ependymal in nature; intracytoplasmic lumina and intercellular microrosettes lined with cilia and microvilli, as well as long zonulae adherentes, were evident. In addition, chromogranin A-positive granular staining, neurosecretory-granule-like structures, and parallel arrays of microtubules were sometimes associated with the blood vessels. We considered the present case to be an unusual example of GG with an ependymoma, more precisely a tanycytic ependymoma, as the glial component; to our knowledge, the existence of ependymoma as the main glial component of this particular tumor has not been described before. The occurrence of NFTs, which has been reported in several cases of GG, was an additional, unusual feature.

show abstract

Distribution of epithelial membrane antigen in normal and neoplastic human ependyma

Cited by 39 publications

References 13 publications

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study

Posterior Fossa Neurenteric Cysts Can Expand Rapidly: Case Report

Ganglioglioma with a tanycytic ependymoma as the glial component

Contact Info

Product

Resources

About