“…Furthermore, the neurenteric canal may allow the migration of multipotent endodermal cells producing neuroendodermal cysts (or neurenteric cysts in the old nomenclature of de Oliveira et al [2005]) along the entire neuroaxis including the supratentorial space (the cavity cranial to the cerebellum) in infants and middle-aged adults [Mittal et al, 2010]. These cysts can grow enormously in a short time [Priamo et al, 2011], causing neurological symptoms such as paraplegia [Rizk et al, 2001] and the need for neurosurgical intervention with close diagnostic follow-up by magnetic resonance imaging [Yang et al, 2015]. The neurenteric canal has also been suggested to be involved in the development of rare but severe abnormalities summarized as the split notochord syndrome which includes dorsal enteric fistula, a split vertebral column, and intestinal alterations [Bentley and Smith, 1960;Holschneider and Fendel, 1971;Singh and Singh, 1982;Gupta and Deodhar, 1987;Dhawan et al, 2017].…”