Distribution of dopamine receptors and dopamine receptor homologs in the brain of the honey bee,Apis mellifera L.

Kokay, Ilona C.; Ebert, Paul R.; Kirchhof, B.S.; Mercer, Alison R.

doi:10.1002/(sici)1097-0029(19990115/01)44:2/3<179::aid-jemt9>3.0.co;2-k

Cited by 27 publications

(25 citation statements)

References 77 publications

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“…First, Amdop3 (previously referred to as AmBAR3; Ebert et al, 1998;Kokay et al, 1999) encodes a DA receptor and its activation leads to a reduction in intracellular levels Fig. 4.…”

Section: Discussionmentioning

confidence: 99%

“…Here, we examine the functional properties and cellular distribution of the receptor encoded by Amdop3, a putative DA receptor referred to elsewhere as AmBAR3 (Apis mellifera Biogenic Amine Receptor 3; Ebert et al, 1998;Kokay et al, 1999;Humphries et al, 2003). We describe features of the AmDOP3 protein, the functional properties of AmDOP3 receptors and the distribution of cells in the brain expressing Amdop3 mRNA.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera

Beggs

Hamilton

Kurshan

et al. 2005

Insect Biochemistry and Molecular Biology

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“…First, Amdop3 (previously referred to as AmBAR3; Ebert et al, 1998;Kokay et al, 1999) encodes a DA receptor and its activation leads to a reduction in intracellular levels Fig. 4.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera

Beggs

Hamilton

Kurshan

et al. 2005

Insect Biochemistry and Molecular Biology

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“…The subtype-selective ligands used in these studies suggest the presence of both D1-like and D2-like receptors in invertebrates. In vitro binding experiments with isolated membranes and autoradiographic analysis of honey-bee brain provide additional evidence that both D1-and D2-like receptors are expressed in insects (16,17). Studies with selective radioligands revealed localization of respective receptor subtypes in distinct brain regions.…”

mentioning

confidence: 90%

A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants

Hearn

Ren

McBride

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

187

204

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Dopamine is an important neurotransmitter in the central nervous system of both Drosophila and mammals. Despite the evolutionary distance, functional parallels exist between the fly and mammalian dopaminergic systems, with both playing roles in modulating locomotor activity, sexual function, and the response to drugs of abuse. In mammals, dopamine exerts its effects through either dopamine 1-like (D1-like) or D2-like G protein-coupled receptors. Although pharmacologic data suggest the presence of both receptor subtypes in insects, only cDNAs encoding D1-like proteins have been isolated previously. Here we report the cloning and characterization of a newly discovered Drosophila dopamine receptor. Sequence analysis reveals that this putative protein shares highest homology with known mammalian dopamine 2-like receptors. Eight isoforms of the Drosophila D2-like receptor (DD2R) transcript have been identified, each the result of alternative splicing. The encoded heptahelical receptors range in size from 461 to 606 aa, with variability in the length and sequence of the third intracellular loop. Pharmacologic assessment of three DD2R isoforms, DD2R-606, DD2R-506, and DD2R-461, revealed that among the endogenous biogenic amines, dopamine is most potent at each receptor. As established for mammalian D2-like receptors, stimulation of the Drosophila homologs with dopamine triggers pertussis toxin-sensitive Gi͞o-mediated signaling. The D2-like receptor agonist, bromocriptine, has nanomolar potency at DD2R-606, -506, and -461, whereas multiple D2-like receptor antagonists (as established with mammalian receptors) have markedly reduced if any affinity when assessed at the fly receptor isoforms. The isolation of cDNAs encoding Drosophila D2-like receptors extends the range of apparent parallels between the dopaminergic system in flies and mammals. Pharmacologic and genetic manipulation of the DD2Rs will provide the opportunity to better define the physiologic role of these proteins in vivo and further explore the utility of invertebrates as a model system for understanding dopaminergic function in higher organisms. Dopamine is an essential catecholamine in the central nervous system of both mammals (1) and Drosophila (2). In mammals, dopamine modulates neurologic, cardiovascular, endocrine, and renal functions. In addition, this neurotransmitter regulates motor activity, sexual behavior, and the response to drugs of abuse (1, 3-6). In Drosophila, known dopamine-mediated functions overlap with those of mammals. Experimental evidence suggests that in flies dopamine modulates locomotor activity, sexual function and the response to cocaine, nicotine, and alcohol (7-11).Dopaminergic signaling is mediated through seven transmembrane domain (TM) G protein-coupled receptors that fall within the class A or rhodopsin family based on amino acid homology and conservation of amino acid signature motifs. The dopamine receptor family is divided into two major subfamilies: the D1-like receptors (D1 and D5) and D2-like receptors (D2, D3, and ...

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“…DAMB [98] and dDA1 [99], two types of D1 dopamine receptors, are densely distributed in the MB lobes of Drosophila. Further, dopamine receptor homologs are distributed in the MBs of honeybees [100]. The dDA1 in the MBs are essential for fly aversive and appetitive learning [101].…”

Section: Concluding Remarks: the Gating-gain Mechanism In Cognitionmentioning

confidence: 99%

Research progress on Drosophila visual cognition in China

Guo

Zhang

Peng

et al. 2010

Sci. China Life Sci.

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Visual cognition, as one of the fundamental aspects of cognitive neuroscience, is generally associated with high-order brain functions in animals and human. Drosophila, as a model organism, shares certain features of visual cognition in common with mammals at the genetic, molecular, cellular, and even higher behavioral levels. From learning and memory to decision making, Drosophila covers a broad spectrum of higher cognitive behaviors beyond what we had expected. Armed with powerful tools of genetic manipulation in Drosophila, an increasing number of studies have been conducted in order to elucidate the neural circuit mechanisms underlying these cognitive behaviors from a genes-brain-behavior perspective. The goal of this review is to integrate the most important studies on visual cognition in Drosophila carried out in mainland China during the last decade into a body of knowledge encompassing both the basic neural operations and circuitry of higher brain function in Drosophila. Here, we consider a series of the higher cognitive behaviors beyond learning and memory, such as visual pattern recognition, feature and context generalization, different feature memory traces, salience-based decision, attention-like behavior, and cross-modal leaning and memory. We discuss the possible general gain-gating mechanism implementing by dopamine - mushroom body circuit in fly's visual cognition. We hope that our brief review on this aspect will inspire further study on visual cognition in flies, or even beyond.

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Distribution of dopamine receptors and dopamine receptor homologs in the brain of the honey bee,Apis mellifera L.

Cited by 27 publications

References 77 publications

Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera

Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera

A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants

Research progress on Drosophila visual cognition in China

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