Distribution of Disaccharidases, Alkaline Phosphatase, and Some Intracellular Enzymes along the Human Small Intestine

G, N; Gudmand-Høyer, E; Andersen, Bjørn; Berg, Nils O.; Dahlqvist, Arne

doi:10.1080/00365521.1975.12097025

Cited by 61 publications

(7 citation statements)

References 19 publications

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“…The failure of absorption in the distal small intestine may be simply due to lack of time, but the comparatively low activities of brush border hydrolases and limited capacity of glucose transport may also contribute to the malabsorption. Disaccharidase activities are maximal in the proximal and central parts of the small intestine; maltase (EC 3.2.1.20) and isomaltase (EC 3.2.1 .lo) activities decline to half maximal or less in the distal ileum (Asp et al 1975). Finally, some continued hydrolysis after collection of the ileostomy evacuates cannot be excluded, but it should be noted that low molecular weight material was identified also in ileal content collected by intubation (Faisant, 1993 c).…”

Section: H a R A C T E R I Z A T I O N O F R E S I S T A N T S T A mentioning

confidence: 99%

Nutritional Implications Of Resistant Starch

Asp

Amelsvoort

Hautvast³

1996

Nutr. Res. Rev.

180

129

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Section: H a R A C T E R I Z A T I O N O F R E S I S T A N T S T A mentioning

confidence: 99%

Nutritional Implications Of Resistant Starch

Asp

Amelsvoort

Hautvast³

1996

Nutr. Res. Rev.

180

129

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“…It is well known that digestive brush border enzymes mainly attach to the apical parts of villi (Asp et al, 1975). Moreover, the proliferation of villi helps more digestive enzymes to enter the intestine, thereby facilitating the digestion and absorption of more nutrients (Cao et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…This finding was consistent with that of Sun et al (2017) , suggesting that EA administration can change the morphological structure of the mouse jejunum and can promote the development of the small intestine in mice. It is well known that digestive brush border enzymes mainly attach to the apical parts of villi ( Asp et al, 1975 ). Moreover, the proliferation of villi helps more digestive enzymes to enter the intestine, thereby facilitating the digestion and absorption of more nutrients ( Cao et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ellagic Acid Supplementation on Jejunal Morphology, Digestive Enzyme Activities, Antioxidant Capacity, and Microbiota in Mice

Shen

Han

et al. 2021

Front. Microbiol.

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Ellagic acid (EA), a plant polyphenol mainly found in nuts and fruits, exhibits various biological effects. However, the effects of EA on intestinal health remain poorly understood. Hence, the present study aimed to assess the effects of EA supplementation on jejunal morphology, digestive enzyme activities, antioxidant capacity, and microbiota in C57BL/6J mice. A total of 144 mice were randomly assigned to three treatments groups: the control (CON) group received a standard pellet diet, the 0.1% EA group received a standard pellet diet plus 0.1% EA, and the 0.3% EA group received a standard pellet diet plus 0.3% EA. The mice were killed at the end of the experimental period, and jejunal samples were collected. The results revealed that the mice in the 0.3% EA group had higher (P < 0.05) average daily gain and greater (P < 0.05) jejunal villus height than those in the CON group. In addition, the jejunal lactase and sucrase activities were higher (P < 0.05) in the 0.1% EA and 0.3% EA groups, and the alkaline phosphatase activity was higher (P < 0.05) in the 0.3% EA group than in the CON group. Compared with the CON group, the administration of EA increased (P < 0.05) the superoxide dismutase and catalase activities but decreased (P < 0.05) the malonaldehyde content in the jejunum. Moreover, the jejunal messenger RNA expression levels of nuclear factor-E2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1) were higher (P < 0.05) in the 0.3% EA group than in the CON group. Furthermore, compared with the CON group, the count of Escherichia coli decreased (P < 0.05), and that of Lactobacillus species increased (P < 0.05) in the 0.3% EA group. In general, our findings indicate that the administration of EA can enhance the growth of mice, promote intestinal development, increase the antioxidant capacity, and regulate the intestinal microbiota.

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“…Patients 1, 2, and 3 were siblings. The activities of the disaccharidases lactase, sucrase, isomaltase, and maltase in duodenal biopsy specimens were measured according to Asp et al (8). The results are depicted in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Congenital and Putatively Acquired Forms of Sucrase‐isomaltase Deficiency in Infancy: Effects of Sacrosidase Therapy

Lücke

Keiser²,

Illsinger

et al. 2009

J. pediatr. gastroenterol. nutr.

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Sucrase-isomaltase (SI) is localised at the brush-border membrane of the small intestine and is responsible for the hydrolysis of sucrose and other carbohydrates such as palatinose (1,2). Deficiency of this enzyme leads to sucrose and glucan malabsorption resulting in osmotic diarrhoea. Onset of clinical symptoms is usually after the first year of life when sucrose consumption increases. This often results in failure to thrive (3,4). Clinical reports on patients with SI deficiency (SID) are rare. Only limited information about therapeutic success is available in the literature (5-7). We present 4 patients, 3 with congenital and 1 with a putatively acquired SID, who clinically improved after therapy with sacrosidase was initiated.

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Distribution of Disaccharidases, Alkaline Phosphatase, and Some Intracellular Enzymes along the Human Small Intestine

Cited by 61 publications

References 19 publications

Nutritional Implications Of Resistant Starch

Nutritional Implications Of Resistant Starch

Effects of Ellagic Acid Supplementation on Jejunal Morphology, Digestive Enzyme Activities, Antioxidant Capacity, and Microbiota in Mice

Congenital and Putatively Acquired Forms of Sucrase‐isomaltase Deficiency in Infancy: Effects of Sacrosidase Therapy

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