Distribution of Clinically Relevant Blood Group Antigens among Nigerians and the Management of Rhesus D Negative Pregnancies: Implications for Haemolytic Disease of the Foetus and Newborn and Haemolytic Transfusion Reactions

Erhabor, O; Erhabor, Tosan; Adias, Teddy Charles; Polycarp, Iwueke Ikechukwu

doi:10.5772/intechopen.90372

Cited by 6 publications

(10 citation statements)

References 107 publications

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“…Most of the naturally occurring antibodies include anti-Cw, anti-M, and antibodies in the Ii, Lewis, and P systems are not clinically significant, except for ABO antibodies. Furthermore, immune antibodies are clinically significant and produced specifically against RBC antigens such as antibodies in the K, Rh, Duffy, and Kidd systems [1][2][3]. From a total of 360 RBC antigens recognized by the International Society of Blood Transfusion (ISBT), 330 were grouped into 39 blood group systems [4].…”

Section: Introductionmentioning

confidence: 99%

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Hajar

Zulkafli

Riffin

et al. 2020

Egypt J Med Hum Genet

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Background Blood group antigens are immunogenic polymorphic molecules presented on the surface of RBCs. This study aimed to determine extended blood group profiles (ABO, Rhesus, Kell, Kidd, Duffy, MNS, Cartwright, Dombrock, Colton, Lutheran, and Vel) in Malays, Chinese, and Indians in Peninsular Malaysia. Results Here, ABO Type O, DCCee, MNs, and Fy (a+b−) were the most frequent major blood group phenotypes in all three ethnic groups. Other minor blood group systems distributed differently across these ethnic groups, except for the Kell, Lutheran, Cartwright, and Vel blood group systems, where only K+k−, Lu (8+14), Yt (a+b−), and Vel (+) phenotypes were observed. Exact tests of population differentiation generally showed no significant differences between Malays included in the present study vs. other ethnically similar datasets from previous surveys. However, many significant differences were recorded in comparison between blood group datasets from ethnically unrelated populations (Malays vs. Chinese vs. Indians) especially for Rhesus, Kidd, and Duffy blood group systems. A Principal component analysis (PCA) plot showed that population groups from the Peninsular Malaysia map closely together as compared with population groups from other geographical regions. Conclusions Overall, our present study has successfully provided an extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia. These new blood group datasets can be used as guidelines for donor recruitment and as reference standards for studying diseases associated with blood group systems.

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Section: Introductionmentioning

confidence: 99%

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Hajar

Zulkafli

Riffin

et al. 2020

Egypt J Med Hum Genet

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“…In Eastern and Southern African countries, blood group O dominated the populace, while in Pakistan and some regions in India on the Asian continent, blood group B dominated [25][26][27]. In addition to being the most common blood group in our population, the high rate of utilization of blood group O is seen where there is an inadequate supply of donor blood, particularly in emergencies when it is commonly used as universal donor units for transfusion to A, B, and AB recipients, is is predicated on the premise that blood group O red cells lack A and B antigens on their cell membrane surfaces, despite the risk of the presence of anti-A and anti-B haemolysins in blood type O donors [28]. Contrary to the report by Enosolease et al [12], our study revealed that blood utilization was more than supplied by the blood bank.…”

Section: Discussionmentioning

confidence: 99%

Donor Blood Procurement, Safety, and Clinical Utilization: A Study of Blood Transfusion Services in a Tertiary Care Hospital in Nigeria

Nnachi

Uzor

Umeokonkwo

et al. 2022

Anemia

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Background. Donated blood is an essential component of the management of many diseases, and hospital-based blood banks in Nigeria are saddled with the responsibility of provision of safe blood and coordination of its appropriate utilization for patient care. Objective. This study reviewed the extent to which the hospital blood transfusion service ensures adequate safe blood supply and utilization. Materials/Methods. This was a retrospective study of 2 years record of the blood bank service of Alex Ekwueme Federal University Teaching. Methods of donor blood procurement, transfusion transmissible infection status, the pattern of blood, and blood component usage across the hospital’s clinical departments were evaluated. Statistical analysis was conducted using IBM SPSS, and data were presented as percentages. Fisher’s tests were used to test significance, and p value <0.05 is significant. Results. The highest proportion of donors was male family replacement donors aged 26–35 years (3634 (39.68%)) while total voluntary donors were 315 (2.65%). Hepatitis B had the highest seroprevalence 267 (2.22%) among blood-borne diseases screened. National Blood Transfusion Service (NBTS) supplied only 3 (0.03%) of total blood units used. The accident and emergency department had the highest proportion of persons who utilized whole blood; 4568 (99.96%). Conclusion. The hospital blood bank relies heavily on family replacement donors with little or no assistance from the National Blood Transfusion Service. Family replacement donors have the highest risk of TTIs, and hepatitis B infection has the highest prevalence. The high cost of blood component therapy increases the need for whole blood.

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“…Additional clinically useful blood group systems include those of Kell, Duffy, Kidd, MNS, Diegos, and others. (Erhabor et al, 2021). Therefore the relevance of blood group systems is seen in ensuring compatibility of the donor and the recipient.…”

Section: Relevance Of Blood Group Systems In Medical Practicementioning

confidence: 99%

“…The use of compatibility testing helps to avoid alloimmunization and hemolytic transfusion responses when a recipient receives a transfusion of a donor's blood. Sensitization by a foreign antigen and subsequent exposure to the same antigen, respectively, result in alloimmunization and hemolytic transfusion responses (Erhabor et al, 2021;Haryani et al, 2017). The compatibility testing includes: ABO and Rhesus blood typing, antibody screening meant for the detection of unexpected antibodies and cross matching (Obeta et al, 2020).…”

Section: Compatibility Testingmentioning

confidence: 99%

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Blood Group System: Clinical Insight and Relevance in Medical Practice

Olanrewaju

Joy²,

Matthew

2023

EJHS

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Purpose: Thirty three blood group systems have recently received recognition from the International Society of Blood Transfusion. Numerous types of antigens have been found on the red cell membranes in addition to the ABO and Rhesus systems. One of the few significant tests that the anesthesiologist orders during the perioperative period is blood grouping and cross matching. To avoid difficulties associated with transfusions, it is crucial to have a thorough awareness of the blood group system, their clinical importance, typing and cross-matching tests and current implications. To explore the various blood group systems, their clinical significance, and their relevance in medical practice, including transfusion medicine, prenatal care and genetic testing Methodology: Relevant databases such as PubMed, Google Scholar and Scopus to search for literature related to blood group system were used for this study. Search strategy including keywords related to barium studies, cross-sectional imaging and low resource economies. This may include terms such as blood group system, ABO blood group, clinical significance, medical practice. Search terms in combination with Boolean operators (AND, OR, NOT) are used to retrieve relevant articles. Findings: Undoubtedly blood group systems is highly relevant in medical practice so as to prevent haemolytic transfusion reaction and alloimmunization of individual blood which can result to death of infants and other individuals. As beneficial as blood transfusion is blood group system of the donor and recipient must be identified to make the blood transfusion process safe. Blood group systems also gives clinical insights in medical practice which make disease diagnosis and treatment easier to approach. Recommendations: Health care providers should be trained to properly identify and type blood samples and blood banks should have appropriate quality control measures in place to ensure the accuracy of blood typing and cross matching. Healthcare providers involved in organ transplantation should be familiar with the blood group compatibility guidelines and communicate effectively with blood banks to ensure the availability of compatible donor organs.

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Distribution of Clinically Relevant Blood Group Antigens among Nigerians and the Management of Rhesus D Negative Pregnancies: Implications for Haemolytic Disease of the Foetus and Newborn and Haemolytic Transfusion Reactions

Cited by 6 publications

References 107 publications

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Donor Blood Procurement, Safety, and Clinical Utilization: A Study of Blood Transfusion Services in a Tertiary Care Hospital in Nigeria

Blood Group System: Clinical Insight and Relevance in Medical Practice

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