Distribution of CCR5-[delta]32, CCR2-64I, and SDF1-3'A Mutations in Populations from the Brazilian Amazon Region

Carvalhaes, Fernanda Andreza de Pinho Lott; Cardoso, Greice Lemos; Hamoy, Igor; Liu, Yan Tat; Guerreiro, João Farias

doi:10.1353/hub.2004.0052

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…, 0.6% in Cepem, 0.7% in African-Brazilian populations from Pará (Carvalhaes et al , 2004), 0.9 and 1.0% in Bahia (Carvalho et al , 2004), 1.8% in Candelária and Bate-Estaca and 1.9% and 2.0% in African-Brazilian individuals in Rio de Janeiro (Chies and Hutz, 2003) and Paraná (Boldt et al , 2009), respectively. Among HIV + subjects, frequencies ranged from 2.1% in Rio de Janeiro (Teixeira et al , 2009) to 2.4% in Rio Grande do Sul (Vieira et al , 2011), 2.6% in a miscegenated population in Bahia (Grimaldi et al , 2002) and 3.8% in São Paulo (Rigato et al , 2008).…”

Section: Resultsmentioning

confidence: 99%

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Farias¹,

Santos

França

et al. 2012

Genet. Mol. Biol.

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Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of each wave of immigrants. We analyzed the frequency of the CCR5Δ32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in five sample sets from the population. Four were collected in Porto Velho, the state capital and the site of several waves of migration. Of these, two, from the Hospital de Base were comprised of HB Mothers and HB Newborns presenting allele frequencies of 3.5% and 3.1%, respectively, a third from the peri-urban neighborhoods of Candelária/Bate-Estaca (1.8%), whereas a fourth, from the Research Center on Tropical Medicine/CEPEM (0.6%), was composed of malaria patients under treament. The fifth sample (3.4%) came from the inland Quilombola village of Pedras Negras. Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples. The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced. The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

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Section: Resultsmentioning

confidence: 99%

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Farias¹,

Santos

França

et al. 2012

Genet. Mol. Biol.

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“…In urban Brazilian populations not tested for HIV infection the SDF1-3'A allele was found at frequency of 0.223 in the population of Belém (Carvalhaes et al 2004). In non-urban populations this variant was found at frequency of 0.153 in Afro-Brazilian communities and at frequencies of 0.060 to 0.227 in Amerindian tribes from the Brazilian Amazon (Su et al, 1999;Carvalhaes et al 2004).…”

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confidence: 92%

“…The SDF1-3'A allele is widely distributed, and has particularly high frequencies in Oceania, especially in New Guinean Highlanders (up to 72%), but is less common (3% to 12%) in African populations and has been found with frequencies between 15% and 22% in Europeans (Su et al, 1999(Su et al, , 2000. In urban Brazilian populations not tested for HIV infection the SDF1-3'A allele was found at frequency of 0.223 in the population of Belém (Carvalhaes et al 2004). In non-urban populations this variant was found at frequency of 0.153 in Afro-Brazilian communities and at frequencies of 0.060 to 0.227 in Amerindian tribes from the Brazilian Amazon (Su et al, 1999;Carvalhaes et al 2004).…”

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confidence: 97%

“…: European, 13%; African, 17%, Asian 13% (Su et al, 1999(Su et al, , 2000Martinson et al, 2000. A previous study performed on a sample of the general population of the northern Brazilian city of Belém, the capital of the state of Pará, population around 1,4 million (Brazilian Institute of Geography and Statistics -IBGE, 2004) in the Brazilian Amazon revealed the presence of the CCR2-64I mutation at a frequency of 0.161 (Carvalhaes et al, 2004) but higher frequencies have been found in Afro-Brazilians (0.230), whereas in Brazilian Amerindians the frequency of this mutation varies from 0.030 to 0.300 (Su et al, 1999;Acosta et al, 2003;Carvalhaes et al, 2004).…”

mentioning

confidence: 99%

“…In Brazilian urban populations (HIV serological status not determined) the CCR5 variant has been found with frequencies between 0.030 and 0.065 (Passos and Picanço, 1998;Pereira et al, 2000;Munerato et al, 2003;Carvalhaes et al, 2004). This mutation is rare in Afro-Brazilians communities (0.008) and absent in Brazilian Amerindians (Leboute et al, 1999;Su et al, 2000;Grimaldi et al, 2002;Carvalhaes et al, 2004). Smith et al (1997) states that CCR2-64I is a G to A substitution that results in the replacement of valine with Genetics and Molecular Biology, 28, 4, 665-669 (2005) Copyright by the Brazilian Society of Genetics.…”

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Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

et al. 2005

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The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3'A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3'A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.

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Association study of CCR5 delta 32 polymorphism among the HLA‐DRB1 Caucasian population in Northern Paraná, Brazil

Muxel

Borelli

Amarante

et al. 2008

Clinical Laboratory Analysis

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Chemokines are important determinants of early inflammatory response. The CC chemokine receptor 5 (CCR5) delta 32 variant results in a nonfunctional form of the chemokine receptor and has been implicated in a variety of immune-mediated diseases. In the present study, polymerase chain reaction (PCR) for genomic deoxyribonucleic acid (DNA) samples, using specific CCR5 oligonucleotide primers surrounding the breakpoint deletion, detected a 225-basepair (bp) product from the normal CCR5 allele and a 193-bp product from the 32 bp deletion allele. Human leukocyte antigen (HLA) class II (DRB1) typing was performed by PCR-sequence-specific primer (PCR-SSP). The aim of this study was to evaluate the association of HLA-DRB1 and CCR5 genetic polymorphisms. To evaluate the frequency distributions of CCR5 delta 32 polymorphisms in a Brazilian population and their association with allelic distribution of HLA genes, DRB1; a total of 120 Caucasian individuals from northern Paraná, Brazil, were tested. The CCR5/CCR5 genotype was found in 108 individuals (90%) and only one carried the CCR5 delta 32 allele homozygous genotype (0.0238), while 12 (10%) carried the CCR5 delta 32 allele heterozygous genotype. The observed frequency for the CCR5 delta 32 allele was 0.05 in the population studied. The results revealed a CCR5 delta 32 allele occurrence with HLA-DRB1(*)01 and DRB1(*)04 (P<0.05). It is possible that HLA-DRB1(*)01 and DRB1(*)04 alleles could be associated with the delta 32-bp deletion of CCR5.

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Distribution of CCR5-[delta]32, CCR2-64I, and SDF1-3'A Mutations in Populations from the Brazilian Amazon Region

Cited by 11 publications

References 6 publications

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil

Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

Association study of CCR5 delta 32 polymorphism among the HLA‐DRB1 Caucasian population in Northern Paraná, Brazil

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