Association study of CCR5 delta 32 polymorphism among the HLA‐DRB1 Caucasian population in Northern Paraná, Brazil

Muxel, Sandra Márcia; Borelli, Sueli Donizete; Amarante, Marla Karine; Voltarelli, Júlio César; Aoki, Mateus Nóbrega; Oliveira, Carlos Eduardo Coral de; Watanabe, Maria Angélica Ehara

doi:10.1002/jcla.20225

Cited by 15 publications

(12 citation statements)

References 36 publications

(38 reference statements)

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“…A study performed in Brazil found that 108 ‘Caucasians’ who were HLA-typed as either DRB1*01 or DRB1*04 had a significant probability of carrying the CCR5Δ32 allele [26]. However, we did not find any of the 10 CCR5Δ32/Δ32 CBUs to be HLA-DR*01 .…”

Section: Discussioncontrasting

confidence: 81%

Identification and frequency of CCR5Δ32/Δ32 HIV-resistant cord blood units from Houston area hospitals

González¹,

Park²,

Chen³

et al. 2011

HIV Medicine

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Objectives The use of umbilical cord blood (CB) that is genetically resistant to HIV infection has been proposed as a novel stem cell therapy for the treatment of patients with AIDS. These genetically unique CB units (CBUs) should be present in public CB banks at a predicted frequency. Methods The chemokine (C-C motif) receptor 5 (CCR5) genotypes of CBUs donated to the M. D. Anderson CB Bank by four Houston area hospitals were determined by polymerase chain reaction (PCR) and DNA sequencing. Results The frequency of CCR5Δ32/Δ32 CBUs was consistent with the frequency of the CCR5Δ32 allele in human populations, and was apparently dependent on the ethnic population of the parents of the newborns from whom the CBUs were collected. Conclusions Routine genotyping to identify HIV-resistant CBUs could create a bank of CB-derived stem/progenitor cells with which to treat HIV infection.

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Section: Discussioncontrasting

confidence: 81%

Identification and frequency of CCR5Δ32/Δ32 HIV-resistant cord blood units from Houston area hospitals

González¹,

Park²,

Chen³

et al. 2011

HIV Medicine

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“…These results corroborated with studies in different disorders, such as leishmaniasis, breast, laryngeal, thyroid, and brain carcinoma, which also identified no differences in the frequency of these alleles among healthy subjects and patients of Southern Brazilian population [28–30] and worldwide [31–33]. …”

Section: Discussionsupporting

confidence: 87%

Absence of Association betweenCCR5rs333 Polymorphism and Childhood Acute Lymphoblastic Leukemia

Oliveira

Amarante

Perim

et al. 2014

Advances in Hematology

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Acute lymphoblastic leukemia (ALL) is a malignant disorder that originates from one single hematopoietic precursor committed to B- or T-cell lineage. Ordinarily, these cells express CCR5 chemokine receptor, which directs the immune response to a cellular pattern and is involved in cancer pathobiology. The genetic rs333 polymorphism of CCR5 (Δ32), results in a diminished receptor expression, thus leading to impaired cell trafficking. The objective of the present study was to investigate the effect of CCR5 chemokine receptor rs333 polymorphism in the pathogenesis of ALL. The genotype distribution was studied in 79 patients and compared with 80 control subjects, in a childhood population of Southern Brazil. Genotyping was performed using DNA samples amplified by polymerase chain reaction with sequence-specific primers (PCR-SSP). The homozygous (Δ32/Δ32) deletion was not observed in any subject involved in the study. Heterozygous genotype was not associated with ALL risk (OR 0.7%; 95% CI 0.21–2.32; P > 0.05), nor recurrence status of ALL (OR 0.86; 95% CI 0.13–5.48; P > 0.05). This work demonstrated, for the first time, no significant differences in the frequency of the CCR5/Δ32 genotype between ALL and control groups, indicating no effect of this genetic variant on the ALL susceptibility and recurrence risk.

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“…Previous studies in the Brazilian population showed that less than 10% of the investigated individuals carried the heterozygous CCR5Δ-32 genotype 20,21 . The small number of participants included in the present study may have affected the detection of this mutation.…”

Section: Discussionmentioning

confidence: 87%

Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil

Avanzi

Vicente

Beloto

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. Methods: Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. Results: This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4 + T-cell count of 452 cells/mm 3 . HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/ HCV coinfection, and 17 (60.7%) presented the CC genotype. Conclusions: In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses.

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Association study of CCR5 delta 32 polymorphism among the HLA‐DRB1 Caucasian population in Northern Paraná, Brazil

Cited by 15 publications

References 36 publications

Identification and frequency of CCR5Δ32/Δ32 HIV-resistant cord blood units from Houston area hospitals

Identification and frequency of CCR5Δ32/Δ32 HIV-resistant cord blood units from Houston area hospitals

Absence of Association betweenCCR5rs333 Polymorphism and Childhood Acute Lymphoblastic Leukemia

Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil

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