Distribution of capsular types and drug resistance patterns of invasive pediatric Streptococcus pneumoniae isolates in Teheran, Iran

Houri, Hamidreza; Tabatabaei, Sedigheh Rafiei; Saee, Yasaman; Fallah, Fatemeh; Rahbar, Mohammad; Karimi, Abdollah

doi:10.1016/j.ijid.2017.01.020

Cited by 36 publications

(39 citation statements)

References 50 publications

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“…This study investigated molecular characteristics, antimicrobial resistance patterns and capsular types of S. pneumoniae isolated from blood samples in Tehran, Iran. Of the 44 isolates, 73%, 68% and 16% were resistant to erythromycin, tetracycline and penicillin, respectively which were similar to levels reported for these antibiotics among pneumococci isolated in Iran (71%, 67%, 17%) and the rate of resistance in penicillin (16-28%) and erythromycin (67%) in some Asian countries such as Malaysia and Thailand [18,19].…”

Section: Discussionsupporting

confidence: 71%

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Beheshti

Jabalameli

Feizabadi

et al. 2020

Preprint

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Background: Streptococcus pneumoniae causes serious infections worldwide. The aim of this study was to determine the molecular characteristic, antibiotic resistance pattern and capsular types of invasive S. pneumonia in Tehran, Iran. Results: Of the 44 pneumococcal invasive isolates, 39 (89%) were isolated from children and 5 (11%) from adults. The results show that all pneumococcal isolates were susceptible to linezolid but had varying resistance to trimethoprim-sulfamethoxazole (86%), erythromycin (73%), tetracycline (66%), clindamycin (43%), penicillin (16%), chloramphenicol (14%) and levofloxacin (2%). The range of erythromycin, tetracycline and penicillin MICs were 2 - ≥ 256 μg/mL, 4 - ≥ 48 μg/mL, and 0.047 - ≥ 256 respectively. All of the penicillin resistant isolates were multidrug resistant (MDR) and in addition to penicillin were resistant to tetracycline, erythromycin and trimethoprim-sulfamethoxazole. The most common capsular types detected in 64% of the pneumococcal isolates was 6A/B, 19A, 15A, 23F. The multilocus sequence typing (MLST) of 10 pneumococcal isolates revealed 9 different sequence types (STs), including ST 15139 (capsular type 19A) and ST 15140 (capsular type 23F), which have not previously been reported.Conclusions: The study revealed that the S. pneumonia isolates belonged to diverse capsular types and clones with high rate of resistance to erythromycin, tetracycline, and penicillin.

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Section: Discussionsupporting

confidence: 71%

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Beheshti

Jabalameli

Feizabadi

et al. 2020

Preprint

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“…For other b-lactam antibiotics, the rates of resistance were higher than those reported in previous studies performed in Tunisia, Europe, China, and Iran (Charfi et al, 2012;Rachdi et al, 2011;Raddaoui et al, 2015;Pan et al, 2015;Imöhl et al, 2009;Houri et al, 2017). The increase in resistance to third-generation cephalosporins is alarming.…”

Section: Discussionmentioning

confidence: 82%

Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae strains in the south of Tunisia: A five-year study (2012–2016) of pediatric and adult populations

Ktari

Jmal

Mroua

et al. 2017

International Journal of Infectious Diseases

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“…34 Furthermore, non-susceptibility rate to ceftriaxone has increased slightly, compared to the previous study in the same area in 2017. 12 Increasing trend of resistance to ceftriaxone is related to selective pressure by antibiotic overuse, while ceftriaxone is still a good choice for empirical treatment. Similar to several other studies, the rate of erythromycin-resistance was high (61.25%) in the present study, mainly due to its highly overuse for the treatment of respiratory tract infections.…”

Section: Discussionmentioning

confidence: 99%

“…Limited data of pneumococcal serotypes from Iran is available for the last decade. 12,13 In addition, applying PCV-13 in the national immunization schedule reduces the incidence of pneumococcal diseases in both vaccinated and unvaccinated individuals of all ages. 14 The present study aims to analyze the serotype distribution of S. pneumoniae isolates to determine the PCV-13 serotype coverage.…”

Section: Introductionmentioning

confidence: 99%

<p>Serotype Distribution and Antibiotic Susceptibility of <em>Streptococcus pneumoniae</em> Isolates in Tehran, Iran: A Surveillance Study</p>

Ghahfarokhi¹,

Mosadegh²,

Ahmadi³

et al. 2020

IDR

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Introduction: Encapsulated Streptococcus pneumoniae strains cause high morbidity and mortality, mainly in countries with no pneumococcal conjugate vaccines (PCVs) immunization program. This study investigated the epidemiological changes of S. pneumoniae isolates including serotype distribution and antimicrobial susceptibility in Tehran, Iran. Methods: A total of 80 S. pneumoniae samples were collected from patients admitted to Shariati hospital over two periods. Half of the isolates were collected . The antimicrobial susceptibility testing and PCV-13 serotype coverage of S. pneumoniae isolates were evaluated among patients with invasive and non-invasive infections. Results: The most common serotypes were 23F (17.5%), 14 (16.3%), 3 (16.3%) 19F (12.5%), and 19A (12.5%) in the present study. The vaccine coverage rates of PCV-7, PCV-10 and PCV-13 were 52.6%, 52.6%, and 83.7%, respectively. S. pneumoniae isolates with the serotype of the PCV-13 showed an increasing trend during the study. Nearly half of the S. pneumoniae strains were MDR, while MDR serotype 19A increased (40%) during the study periods. A small minority of isolates (16%) belonged to non-vaccine serotypes, 65% of which were assigned to MDR. In general, the frequency of penicillin resistant and MDR strains were estimated about 27.5% and 51%, respectively. An increase was observed in resistance to erythromycin and co-trimoxazole. Conclusion: The results showed that majority of the circulating serotypes in our study are related to PCV-13 serotypes. The use of conjugate vaccine in the immunization program and surveillance of antimicrobial resistance can be effective in reducing the pneumococcal clinical burden.

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Distribution of capsular types and drug resistance patterns of invasive pediatric Streptococcus pneumoniae isolates in Teheran, Iran

Cited by 36 publications

References 50 publications

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae strains in the south of Tunisia: A five-year study (2012–2016) of pediatric and adult populations

<p>Serotype Distribution and Antibiotic Susceptibility of <em>Streptococcus pneumoniae</em> Isolates in Tehran, Iran: A Surveillance Study</p>

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