Distribution of blood flow velocity in the normal aorta: Effect of age and gender

García, Julio; Palen, Roel L.F. van der; Bollache, Emilie; Jarvis, Kelly; Rose, Michael J.; Barker, Alex J.; Collins, Jeremy D.; Carr, James C.; Robinson, Joshua D.; Rigsby, Cynthia K.; Markl, Michael

doi:10.1002/jmri.25773

Cited by 53 publications

(63 citation statements)

References 38 publications

(95 reference statements)

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“…Generally, cardiac hypertrophy with diastolic dysfunction and enlarged diameter of the aorta are regarded as aging‐associated cardiovascular structural changes. Among these, aorta narrowing does not coincide with previous reports . This discrepancy might be derived from a population bias, as the size of the population analyzed was not large.…”

Section: Discussioncontrasting

confidence: 75%

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Epigenetic status of subtelomere of peripheral leukocytes corresponds to cardiographic parameters with a sex association

Maeda

Horiuchi

Makino

2018

Geriatrics Gerontology Int

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Cardiac function correlates not only with telomere length, but also with the distribution of the telomere length and subtelomeric DNA methylation status. These imply that the loss of young cells, the accumulation of old cells and the acceleration of such changes in the cell population relate to phenotypes of cardiac aging with relative sex specificity. Furthermore, the PR interval showed a very close association with telomeric parameters in both sexes. Hence, PR is the most reliable candidate as an indicator of biological aging in both sexes. Geriatr Gerontol Int 2018; 18: 1415-1419.

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Section: Discussioncontrasting

confidence: 75%

“…Among these, aorta narrowing does not coincide with previous reports. 19,20 This discrepancy might be derived from a population bias, as the size of the population analyzed was not large. Racial bias is also possible, as the study population was limited to Japanese individuals.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic status of subtelomere of peripheral leukocytes corresponds to cardiographic parameters with a sex association

Maeda

Horiuchi

Makino

2018

Geriatrics Gerontology Int

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“…These differences do not exceed the WSS differences that have been found between younger TGA patients and healthy subjects, neither will they explain the WSS asymmetry results in this study. Moreover, in healthy adolescents and young adults flow velocity distribution descriptors indicating velocity symmetry and shape (ie, skewness and kurtosis) only started to increase significantly beyond the age of 40 years . Hence, small differences in age between TGA patients and the healthy control group in this study will not have affected normalized FD measures.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, the velocity of the aortic flow will decrease with increasing age, 33 which could have lowered the WSS results in healthy subjects, as WSS is closely related to velocity since it is a derivative of velocity. 34,35 However, the relatively small age difference between the adolescent TGA patient group and the healthy young adult subjects is not expected to lead to large differences in mean velocity according to the study on the distribution of velocity in the normal aorta over age by Garcia et al 33 Therefore, only small differences in WSS are to be expected based on the age difference. These differences do not exceed the WSS differences that have been found between younger TGA patients and healthy subjects, neither will they explain the WSS asymmetry results in this study.…”

Section: Discussionmentioning

confidence: 99%

Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries

Palen

Deurvorst

Kroft

et al. 2019

Magnetic Resonance Imaging

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Background Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo‐aortic root dilatation as an important complication. Geometry‐related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo). Purpose To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo‐aortic geometry in children after ASO. Study Type Prospective. Population Twenty‐eight TGA patients after ASO and 10 healthy volunteers. Field Strength/Sequence 3.0T/4D flow (segmented fast‐spoiled echo pulse), noncontrast‐enhanced MR angiography (Dixon), and anatomic images (SSFP). Assessment Aortic diameters and body surface area‐indexed aortic dimensions (Z‐scores), normalized FD and planar ascending aortic WSS. Statistical Tests Mann–Whitney and chi‐square tests for differences in FD magnitude, WSS, and FD directionality between groups, respectively. Spearman rank correlation to assess the degree of association between aortic geometry, FD and WSS parameters. Shapiro–Wilk test to evaluate distribution normality on the absolute differences in octant location between FD and WSS. Results TGA patients showed a significantly dilated proximal AAo and relatively small mid‐AAo dimensions at the level of the pulmonary arteries (Z‐scores neo‐aortic root: 4.38 ± 1.96 vs. 1.52 ± 0.70, P < 0.001; sinotubular junction: 3.48 ± 2.67 vs. 1.38 ± 1.30, P = 0.010; mid‐AAo: 0.32 ± 3.06 vs. 1.69 ± 1.24, P = 0.001). FD magnitude was higher in TGA patients (neo‐aortic root: 0.048 ± 0.027 vs. 0.021 ± 0.006, P < 0.001; sinotubular junction: 0.054 ± 0.037 vs. 0.029 ± 0.013, P < 0.05) and was related to the neo‐aortic Z‐score. Clear areas of higher WSS at the right and anterior aortic wall regions along the distal AAo were detected in TGA patients, most pronounced in those with relatively smaller mid‐AAo diameters. Data Conclusion TGA‐specific geometry related to the ASO, evidenced by neo‐aortic root dilatation and a sudden change in vessel diameter at mid‐AAo level, leads to more aortic flow asymmetry in the proximal AAo and WSS distribution with higher WSS at the right and anterior aortic wall regions along the distal AAo. Level of Evidence: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1105–1116.

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“…In contrast, the arterial signal in distal branches was less dependent on the arterial inflowing speed for the VSI‐based approach, as reflected in both representative cases (Figures and ) and the quantitative evaluation of the artery‐to‐tissue relative contrast ratios within the group (Figure ). Velocities of aorta with normal cardiovascular functions were reported to be correlated with, for example, heart rate, age, gender, and body size . Older subjects tend to have slower flow velocity (Figure ) and thus might benefit more from the VSI‐based method.…”

Section: Discussionmentioning

confidence: 99%

Non‐contrast‐enhanced abdominal MRA at 3 T using velocity‐selective pulse trains

Zhu

Liu

et al. 2020

Magnetic Resonance in Med

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Purpose: Most existing non-contrast-enhanced methods for abdominal MR arteriography rely on a spatially selective inversion (SSI) pulse with a delay to null both static tissue and venous blood, and are limited to small spatial coverage due to the sensitivity to slow arterial inflow. Velocity-selective inversion (VSI) based approach has been shown to preserve the arterial blood inside the imaging volume at 1.5 T.Recently, velocity-selective saturation (VSS) pulse trains were applied to suppress the static tissue and have been combined with SSI pulses for cerebral MR arteriography at 3 T. The aim of this study is to construct an abdominal MRA protocol with large spatial coverage at 3 T using advanced velocity-selective pulse trains. Methods: Multiple velocity-selective MRA protocols with different sequence modules and 3D acquisition methods were evaluated. Sequences using VSS only as well as SSI+VSS and VSI+VSS preparations were then compared among a group of healthy young and middle-aged volunteers. Using MRA without any preparations as reference, relative signal ratios and relative contrast ratios of different vascular segments were quantitatively analyzed. Results: Both SSI+VSS and VSI+VSS arteriograms achieved high artery-to-tissue and artery-to-vein relative contrast ratios above aortic bifurcation. The SSI+VSS sequence yielded lower signal at the bilateral iliac arteries than VSI+VSS, reflecting the benefit of the VSI preparation for imaging the distal branches. Conclusion: The feasibility of noncontrast 3D MR abdominal arteriography was demonstrated on healthy volunteers using a combination of VSS pulse trains and SSI or VSI pulse. K E Y W O R D S abdominal MRA, arteriography, non-contrast-enhanced MRA, velocity-selective pulse train 1174 | ZHU et al.

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Distribution of blood flow velocity in the normal aorta: Effect of age and gender

Abstract: 3 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:487-498.

Cited by 53 publications

References 38 publications

Epigenetic status of subtelomere of peripheral leukocytes corresponds to cardiographic parameters with a sex association

Epigenetic status of subtelomere of peripheral leukocytes corresponds to cardiographic parameters with a sex association

Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries

Non‐contrast‐enhanced abdominal MRA at 3 T using velocity‐selective pulse trains

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