Distribution of basement membrane zone components in bullous lesions of subepidermal blistering diseases

Case of pemphigoid involving skin and mucous membrane with immunoglobulin G autoantibodies targeted to BP180 and laminin‐332

“…Previously, we examined the separation site of subepidermal blistering by IF study of the lesional skin samples using antibody to laminin-332. 4 Laminin-332 was detected on dermal, epidermal and both sides of the blister in BP, epidermolysis bullosa acquisita and MMP, respectively. The autoantibody to laminin-332 may be pathogenic in this case, because the blister formed inside the laminin-332 layer as seen in MMP cases, although the pathogenic mechanism needs further elucidation.…”

A case of dermatitis herpetiformis with blister formation between laminin‐332 and type 7 collagen

“…1,2 Our study clearly showed that the level of cleavage was between type 7 collagen and laminin-332 in this case, similar to in epidermolysis bullosa acquisita and different from bullous pemphigoid, as demonstrated in our previous study. 3 The vesicles of DH are recognized to develop in the lamina lucida based on the previous studies. 1,2 Klein et al 1 studied seven DH patients and laminin was found on the floor of vesicles in five patients, while on the roof of vesicles in two patients.…”

“…Case of anti-laminin gamma-1 pemphigoid with antibody against C-terminal domain of BP180 in a patient with psoriasis vulgaris Dear Editor, Anti-laminin gamma-1 pemphigoid is an autoimmune subepidermal bullous disease first reported by Chen et al 1 and Zillikens et al 2 In 1996. Dainichi et al 3 identified the target antigen as laminin gamma-1. Anti-laminin gamma-1 pemphigoid is known to frequently coexist with psoriasis.…”