Distribution of Antibiotic Resistance Genes in Karst River and Its Ecological Risk

Zhang, Biao; Qin, Shang; Guan, Xiangyu; Jiang, Kaidi; Jiang, Minhui; Liu, Fei

doi:10.1016/j.watres.2021.117507

Cited by 59 publications

(26 citation statements)

References 64 publications

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“…At the same time, seasonally, the total number of detected ARGs in the water of summer was significantly higher (One-way ANOVA, F = 35.34, p < 0.01) than in the water of winter. This result was consistent with the results of the Karst River and Ebinur Lake (Xinjiang) [16,38]. There are many types of resistance genes associated with antibiotics.…”

Section: Occurrence Of Args and Mges In The Water And Sediment Sample...supporting

confidence: 92%

“…Meanwhile, drinking water sources are inevitably disturbed by human activities, and the influencing factors of ARGs may be more complex and diverse. This result about the number and types of detected ARGs in this study was similar with that in many previous studies for rivers, lakes and STPs [16,28,32,36,37]. The total number of ARGs detected in water and sediment samples of summer and winter of the Douhe Reservoir and cascade reservoir group are shown in Fig.…”

Section: Occurrence Of Args and Mges In The Water And Sediment Sample...supporting

confidence: 90%

“…Similarly, studies have shown that ARGs were detected in all types of environments, such as the atmosphere [12], water [13], and soil [14,15]. In particular, the occurrence and spread of ARGs in lakes and reservoirs will affect the bacterial community structures and functions in the water body, which would affect the biochemical cycle of the lakes/reservoirs and the migration, transformation and natural degradation of pollutants, and the aquatic ecosystems have been destroyed ultimately [16,17]. Studies have proved that ARGs can persist in the environment and can be spread therein, relying on the mobile genetic elements (MGEs) (e.g., insertion sequence, integrons, and plasmids) by the horizontal gene transfer (HGT) among different bacterial communities, which may have more detrimental influence on the ecological environment and human health than the antibiotics themselves [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the environmental factors such as temperature, nutrients and heavy metals can impact the HGT of sediment and bacterial communities in water. In Karst River (Guizhou), the environmental factors such as bicarbonate ions (HCO-3) and nitrate-nitrogen (NO-3-N) concentration are obviously correlated with ARGs and MGEs [16]. Heavy metals such as Cd and Cr are significantly correlated with ARGs in solid waste leachates in Shanghai [18].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of antibiotic resistance genes in drinking water sources of the Douhe Reservoir, Tangshan, northern China: the correlation with bacterial communities and environmental factors

et al. 2022

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Background Antibiotics and antibiotic resistance genes (ARGs) threaten ecological sustainability and human health, especially the drinking water sources of the Douhe Reservoir, which have critical significance amid their direct use by people and the ecological hub of flora and fauna. Although antibiotics and ARGs pollution in reservoirs have been reported, it is of no practical significance to only study the changes (increase or decrease) of the abundance and diversity of ARGs, and it is more important to explore the mechanisms of the changes affecting ARGs. Thus, the occurrence and prevalence characterizations of the spatial and seasonal of the ARGs, mobile genetic elements (MGEs) and bacterial communities were comprehensively studied in present study. Results 263 ARG (nine types of ARGs) and 51 MGE subtypes were detected in 56 samples, and the characteristics of the temporal and spatial distribution of ARGs, MGEs and the composition of bacterial communities were significantly different. Moreover, the correlation among the ARGs, bacterial communities, MGEs and environmental factors were defined, and the co-occurrence patterns associated with ARG subtypes, bacterial genera, and MGE subtypes between water and sediment of the Douhe Reservoir were different. Conclusions In summary, ARGs were ubiquitous presence in water and sediment of the Douhe Reservoir, and the multidrug, aminoglycoside and macrolide–lincosamide–streptogramin B (MLSB) were main types of ARGs. Bacterial genera and the environmental factors [such as temperature (T), nitrate–nitrogen (NO– 3–N), total dissolved nitrogen (TDN), and total phosphorus (TP)] significantly affected the distribution pattern of ARGs. Overall, this research revealed the spatiotemporal change and transmission mechanisms of ARGs in the typical drinking water sources of reservoirs, which will supply clues to ensure the safety of water sources.

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Section: Occurrence Of Args and Mges In The Water And Sediment Sample...supporting

confidence: 92%

Section: Occurrence Of Args and Mges In The Water And Sediment Sample...supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of antibiotic resistance genes in drinking water sources of the Douhe Reservoir, Tangshan, northern China: the correlation with bacterial communities and environmental factors

et al. 2022

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“…In recent years, with the rapid development of aquaculture, the pollution of antibiotics in the water environment has become increasingly more serious [ 1 , 2 ]. Due to the complex molecular structure and numerous intermediate products of antibiotics, they can be harmful to biological health [ 3 , 4 ]. Among them, oxytetracycline (OTC) is one of the most widely used veterinary antibiotics; aquaculture wastewater constantly enters the environment and gradually accumulates, where long-term exposure can disrupt the balance of the ecosystems, leading to pathogenic microorganisms developing resistance [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Oxytetracycline Removal by Coconut Shell Biochar Loaded with Nano-Zero-Valent Iron

Zhao

Wang

2021

IJERPH

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In this paper, coconut shell biochar (BC), pickling biochar (HBC), and nano-zero-valent iron-loaded biochar (nZVI-HBC) were prepared; these were used to remove oxytetracycline (OTC), and the removal mechanism and degradation product were analyzed. These biochars were characterized using SEM, XRD, FTIR, and XPS. The effects of biochar addition amount, pH, ion type, and ion concentration on OTC adsorption were studied by a batch adsorption experiment. Under the optimal conditions, the equilibrium adsorption capacity of nZVI-HBC to OTC was 196.70 mg·g−1. The adsorption process can be described by Langmuir isothermal adsorption equations, conforming to the pseudo-second-order dynamics model, indicating that adsorption is dominated by single-molecule chemical adsorption, and a spontaneous process of increasing heat absorption entropy. Mass spectrometry showed that the OTC removal process of nZVI-HBC included not only adsorption but also degradation. These results provide a practical and potentially valuable material for the removal of OTC.

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Effects of antibiotic resistance genes on health risks of rivers in habitat of wild animals under human disturbance – based on analysis of antibiotic resistance genes and virulence factors in microbes of river sediments

Hu,

Ren,

Liang

et al. 2024

Ecology and Evolution

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Studying the ecological risk of antibiotic resistance genes (ARGs) to wild animals from human disturbance (HD) is an important aspect of “One Health”. The highest risk level of ARGs is reflected in pathogenic antibiotic‐resistant bacteria (PARBs). Metagenomics was used to analyze the characteristics of PARBs in river sediments. Then, the total contribution of ARGs and virulence factors (VFs) were assessed to determine the health risk of PARBs to the rivers. Results showed that HD increased the diversity and total relative abundance of ARG groups, as well as increased the kinds of PARBs, their total relative abundance, and their gene numbers of ARGs and VFs. The total health risks of PARBs in wild habitat group (CK group), agriculture group (WA group), grazing group (WG group), and domestic sewage group (WS group) were 0.067 × 10−3, −1.55 × 10−3, 87.93 × 10−3, and 153.53 × 10−3, respectively. Grazing and domestic sewage increased the health risk of PARBs. However, agriculture did not increase the total health risk of the rivers, but agriculture also introduced new pathogenic mechanisms and increased the range of drug resistance. More serious was the increased transfer risk of ARGs in the PARBs from the rivers to wild animals under agriculture and grazing. If the ARGs in the PARBs are transferred from the rivers under HD to wild animals, then wild animals may face severe challenges of acquiring new pathogenic mechanisms and developing resistance to antibiotics. Further analysis showed that the total phosphorus (TP) and dissolved organic nitrogen (DON) were related to the risk of ARGs. Therefore, controlling human emissions of TP and DON could reduce the health risk of rivers.

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Distribution of Antibiotic Resistance Genes in Karst River and Its Ecological Risk

Cited by 59 publications

References 64 publications

Characterization of antibiotic resistance genes in drinking water sources of the Douhe Reservoir, Tangshan, northern China: the correlation with bacterial communities and environmental factors

Characterization of antibiotic resistance genes in drinking water sources of the Douhe Reservoir, Tangshan, northern China: the correlation with bacterial communities and environmental factors

Mechanism of Oxytetracycline Removal by Coconut Shell Biochar Loaded with Nano-Zero-Valent Iron

Effects of antibiotic resistance genes on health risks of rivers in habitat of wild animals under human disturbance – based on analysis of antibiotic resistance genes and virulence factors in microbes of river sediments

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