Distribution of aluminum in different brain regions and body organs of rat

Abstract

In the present study, an attempt has been made to investigate the distribution of aluminum in different regions of brain and body organs of male albino rats, following subacute and acute aluminum exposure. Aluminum was observed to accumulate in all regions of the brain with maximum accumulation in the hippocampus. Subcellular distribution of aluminum indicated that there was maximum localization in the nucleus followed by cytosolic, microsomal, and mitochondrial deposition. Elution profile of cytosolic proteins on G-75 Sephadex column revealed a substantial amount of aluminum bound to high-mol-wt protein fraction. Aluminum was also seen to compartmentalize in almost all the tissues of the body to varying extents, and the highest accumulation was in the spleen.

The Potential Effect of Caffeine and Nicotine Co-administration against Aluminum-induced Alzheimer's disease in Rats

“…These results indicate impairment of learning ability and spatial memory. It is well known that Al accumulates in all regions of rat brain following chronic exposure; maximum being in hippocampus which is the site of memory and learning [45]. In the present study, administration of AlCl 3 resulted in marked elevation in the number of trials to avoid the electric shock at the 1 st and 2 nd days of the conditioned-avoidance and learning test as compared to control group.…”

Involvement of altered cytoskeletal protein phosphorylation in aluminum-induced CNS dysfunction

“…A previous study by us (25) revealed that Al significantly accumulated in all the regions of the rat brain following subacute exposure. Maximal Al accumulation was observed in the hippocampus (a seat of memory and learning in the brain), following chronic Al exposure.…”

Heavy metals and DNA damage in blood cells of insectivore bats in coal mining areas of Catarinense coal basin, Brazil

“…Although the elements Al and Si are not considered heavy metals, we decided to include them in this study because of the recognized toxicity of Al to all living forms, as reported by several authors (Exley et al, 1991;Kandiah and Kies, 1994;Julka et al, 1996;Bishop et al, 1997) and the role of Si in the Al uptake by plants (Charles et al, 1991;Cocker et al, 1997;Cocker et al, 1998).…”