Distribution and persistence of residual T-2 and HT-2 toxins from moldy feed in broiler chickens

Yang, Lingchen; Tu, Di; Wu, Yingxin; Liu, Wei; Hu, Yi; Liu, Tanbin; Tan, Lei; Li, Yalan; Lei, Hongyu; Zhan, Yang; Wang, Naidong; Deng, Zhibang; Guo, Shiyin; Wang, Aibing

doi:10.1016/j.toxicon.2020.02.023

Cited by 10 publications

(11 citation statements)

References 24 publications

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“…Interestingly, no ferroptosis-related genes or proteins were significantly differentially expressed in the liver, contrary to what was observed in the pancreas. This may be due to variations in the T-2 toxin residues, which display varying degrees of cytotoxicity in different tissues …”

Section: Discussionmentioning

confidence: 99%

“…This may be due to variations in the T-2 toxin residues, which display varying degrees of cytotoxicity in different tissues. 34 INSR and IRS1 play significant roles in mediating insulin signaling. Once insulin binds to INSR in the liver, it is autophosphorylated and activated, which mediates tyrosine phosphorylation of IRS1.…”

Section: Tannic Acid Ameliorates T-2 Toxin-induced Pancreatic Ferropt...mentioning

confidence: 99%

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Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure

Liu

et al. 2023

J. Agric. Food Chem.

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Subacute mycotoxin exposure in food is commonly overlooked. As one of the most toxic trichothecene mycotoxins, the T-2 toxin severely pollutes human foods and animal feeds. In our study, we investigated the effects of low-dose T-2 toxin on glucose and lipid metabolic function and further investigated the protective effect of tannic acid (TA) in C57BL/6J mice. Results showed that low-dose T-2 toxin significantly impaired blood glucose and lipid homeostasis, promoted ferroptosis in the pancreas and subsequent repression of insulin secretion in β-cells, and impacted hepatic glucose and lipid metabolism by targeted inhibition of the insulin receptor substrate (IRS)/phosphatidylin-ositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, which induced insulin resistance and steatosis in the liver. TA treatment attenuated pancreatic function and hepatic metabolism by ameliorating oxidative stress and insulin resistance in mice. These findings provide new perspectives on the toxic mechanism and intervention of chronic subacute toxicity of foodborne mycotoxins.

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Section: Discussionmentioning

confidence: 99%

Section: Tannic Acid Ameliorates T-2 Toxin-induced Pancreatic Ferropt...mentioning

confidence: 99%

Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure

Liu

et al. 2023

J. Agric. Food Chem.

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“…Meanwhile, fully quantitative methodologies are usually performed on more technological platforms such as liquid chromatography coupled to mass spectrometry (LC-MS) which serves to increase both the speed and analytical complexity, but with a more accurate end result. Furthermore, the use of fully quantitative methods is more expensive than screening methods, leading to greater cost [ 118 ].…”

Section: Methodsmentioning

confidence: 99%

T-2 and HT-2 Toxins: Toxicity, Occurrence and Analysis: A Review

Meneely,

Greer,

Kolawole

et al. 2023

Toxins

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One of the major classes of mycotoxins posing serious hazards to humans and animals and potentially causing severe economic impact to the cereal industry are the trichothecenes, produced by many fungal genera. As such, indicative limits for the sum of T-2 and HT-2 were introduced in the European Union in 2013 and discussions are ongoing as to the establishment of maximum levels. This review provides a concise assessment of the existing understanding concerning the toxicological effects of T-2 and HT-2 in humans and animals, their biosynthetic pathways, occurrence, impact of climate change on their production and an evaluation of the analytical methods applied to their detection. This study highlights that the ecology of F. sporotrichioides and F. langsethiae as well as the influence of interacting environmental factors on their growth and activation of biosynthetic genes are still not fully understood. Predictive models of Fusarium growth and subsequent mycotoxin production would be beneficial in predicting the risk of contamination and thus aid early mitigation. With the likelihood of regulatory maximum limits being introduced, increased surveillance using rapid, on-site tests in addition to confirmatory methods will be required. allowing the industry to be proactive rather than reactive.

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“…However, these methods have high requirements on equipment, large energy consumption, and are generally suitable for materials with light mildew and large particles ( 12 , 13 ). The chemical methods involve treating ZEN-contaminated materials with acid, alkali, ammonia and strong oxidizing reagents ( 14 , 15 ). Nevertheless, chemical reagents tend to destroy toxins structures and cause reagent residue ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

“…The chemical methods involve treating ZEN-contaminated materials with acid, alkali, ammonia and strong oxidizing reagents ( 14 , 15 ). Nevertheless, chemical reagents tend to destroy toxins structures and cause reagent residue ( 15 ). In contrast, microorganism methods have advantages of mild reaction conditions, low energy consumption, environmental friendliness, less nutrients destruction, strong specificity ( 11 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Capacity and kinetics of zearalenone adsorption by Geotrichum candidum LG-8 and its dried fragments in solution

Jiao,

Cui,

Shi

et al. 2024

Front. Nutr.

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The application of LG-8 and its dry fragments as zearalenone (ZEN) adsorbents was investigated. The study showed that Geotrichum candidum LG-8 and its fragments dried at 55°C or through lyophilization are able to adsorb around 80% of ZEN. However, besides in water and 55°C-drying conditions, SEM indicated that higher 90% of ZEN binding tended to occur when cell walls of fragments were intact with less adhesion among themselves. Notably, ZEN/LG-8 fragments complexes were quite stable, as only 1.262% and 1.969% of ZEN were released after successive pH treatments for 4 h and 5 min. The kinetic data signified that adsorption of ZEN onto LG-8 fragments followed well the pseudo-first-order kinetic model. Isotherm calculations showed Langmuir model was favourable and monolayer adsorption of ZEN occurred at functional binding sites on fragments surface. Therefore, we conclude that it can be an alternative biosorbent to treat water contained with ZEN, since LG-8 is low-cost biomass and its fragments have a considerable high biosorption capacity avoiding impacting final product quality and immunodeficient patients.

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Distribution and persistence of residual T-2 and HT-2 toxins from moldy feed in broiler chickens

Cited by 10 publications

References 24 publications

Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure

Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure

T-2 and HT-2 Toxins: Toxicity, Occurrence and Analysis: A Review

Capacity and kinetics of zearalenone adsorption by Geotrichum candidum LG-8 and its dried fragments in solution

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